Patient's own bone-marrow stromal cells could treat multi-drug resistant TB

Published on January 10, 2014 at 6:26 AM · No Comments

Co-author Professor Alimuddin Zumla from University College London, UK adds, “The results of this novel and exciting study show that the current challenges and difficulties of treating MDR-TB are not insurmountable, and they bring a unique opportunity with a fresh solution to treat hundreds of thousands of people who die unnecessarily of drug-resistant TB. Further evaluation in phase 2 trials is now urgently required to ascertain efficacy and further safety in different geographical regions such as South Africa where MDR-TB and XDR-TB are rife.”

Writing in a linked Comment, Professor Robert J Wilkinson from Imperial College London, UK discusses the “long history” of adjunctive immunotherapy against TB, concluding that, “This field is…complex with an underlying problem being a relatively poor understanding of what constitutes protective and pathological immunity in human tuberculosis or even whether these are precisely separable. Nevertheless, the potential to investigate an increasing range of more specific biological therapies or the repurposing of existing anti-inflammatory agents continues to attract interest. Whether relatively complex and expensive MSC therapy will join this list remains to be determined.”

Source: http://www.thelancet.com/

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