Nerve growth factor can be delivered to the brain by intranasal administration without risk for treatment of brain diseases.
Dr. Luigi Aloe, Cellular Biology and Neurobiology Institute, National Research Council, Italy and his team performed a study to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons.
Results showed that at 3 weeks after intranasal administration of nerve growth factor, the contents of nerve growth factor and its receptor in the spinal cord were increased, and the deficits in locomotor behaviors were improved. These findings indicate that intranasal nerve growth factor can bypass blood-brain barrier and affect spinal cord neurons in spinal cord injury. These results provide experimental evidence for intranasal nerve growth factor for repair of spinal cord injury. Related results were published in Neural Regeneration Research (Vol. 9, No. 10, 2014).