Resistance training may have protective effect on the brain in multiple sclerosis patients

In the past, multiple sclerosis patients were advised not to exercise for fear of exacerbating the illness. However, it is now known that physical training can relieve many of the symptoms, including the excessive fatigue and mobility impairments that are often seen. New research now shows that resistance training may protect the nervous system and thus slow the progression of the disease.

This is the main finding of a study conducted by a research partnership between Aarhus University, Aarhus University Hospital, the University of Southern Denmark and the University Medical Center Hamburg-Eppendorf, that has just been published in Multiple Sclerosis Journal.

The study shows that resistance training has a number of positive effects on the brain, which go beyond what can be achieved through effective disease specific medication.

"Over the past six years, we have been pursuing the idea that physical training has effects on more than just the symptoms, and this study provides the first indications that physical exercise may protect the nervous system against the disease," says one of the researchers behind the study, Associate Professor Ulrik Dalgas from the Department of Public Health at Aarhus University.

"For the past 15 years, we have known that physical exercise does not harm people with multiple sclerosis, but instead often has a positive impact on, for example, their ability to walk, their levels of fatigue, their muscle strength and their aerobic capacity, which has otherwise often deteriorated. But the fact that physical training also seems to have a protective effect on the brain in people with multiple sclerosis is new and important knowledge," says Ulrik Dalgas.

In the study, the researchers followed 35 people with multiple sclerosis for six months. Half of the group engaged in resistance training twice a week, while the other half continued to live their lives normally without systematic training.

Prior to and following the six-month period, the test subjects had their brains MR-scanned, and the researchers could see that there was a tendency for the brain to shrink less in those patients who undertook resistance training.

"Among persons with multiple sclerosis, the brain shrinks markedly faster than normal. Drugs can counter this development, but we saw a tendency that training further minimizes brain shrinkage in patients already receiving medication. In addition, we saw that several smaller brain areas actually started to grow in response to training," says Ulrik Dalgas.

The researchers behind the study are still unable to explain why training has a positive effect on the brain in people with multiple sclerosis. A bigger and more in-depth on-going study will help to clarify this, and may also lead to improved treatment options, says Ulrik Dalgas. However, he stresses that the aim is not to replace medication with physical training.

"Phasing out drugs in favor of training is not realistic. On the other hand, the study indicates that systematic physical training can be a far more important supplement during treatment than has so far been assumed. This aspect needs to be thoroughly explored," says Ulrik Dalgas.

It is not yet clear whether all people with multiple sclerosis can benefit from this type of exercise, as it has not been sufficiently tested in the more severely affected patients. Therefore, Ulrik Dalgas is not recommending that all multiple sclerosis patients throw themselves into intensive physical training regimes without first seeking professional advice.