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Diabetes is a disorder of metabolism—the way the body uses digested food for growth and energy. Most of the food people eat is broken down into glucose, the form of sugar in the blood. Glucose is the main source of fuel for the body.

After digestion, glucose passes into the bloodstream, where it is used by cells for growth and energy. For glucose to get into cells, insulin must be present. Insulin is a hormone produced by the pancreas, a large gland behind the stomach.

When people eat, the pancreas automatically produces the right amount of insulin to move glucose from blood into the cells. In people with diabetes, however, the pancreas either produces little or no insulin, or the cells do not respond appropriately to the insulin that is produced. Glucose builds up in the blood, overflows into the urine, and passes out of the body in the urine. Thus, the body loses its main source of fuel even though the blood contains large amounts of glucose.
Treatment outcomes in type 1 diabetes could be improved across all age groups

Treatment outcomes in type 1 diabetes could be improved across all age groups

In a sweeping analysis assessing the current state of diabetes treatment in the U.S., T1D Exchange researchers conclude that there remains considerable room for improving treatment outcomes in type 1 diabetes across all age groups, but especially for adolescents and young adults. [More]
TGen and Baylor partnership set to increase treatment options for cancer patients

TGen and Baylor partnership set to increase treatment options for cancer patients

The Translational Genomics Research Institute (TGen) and Baylor Research Institute (BRI) at Dallas today announce an agreement that will focus on accelerating early detection and treatments for patients with a broad range of cancers. [More]
Scientists find new way to convert blood cells into sensory neurons

Scientists find new way to convert blood cells into sensory neurons

Scientists at McMaster University have discovered how to make adult sensory neurons from human patients simply by having them roll up their sleeve and providing a blood sample. [More]
Study explores how our intestinal tract changes as we age

Study explores how our intestinal tract changes as we age

Scientists and clinicians on the Norwich Research Park have carried out the first detailed study of how our intestinal tract changes as we age, and how this determines our overall health. [More]
Heart rate measures could identify individuals with higher risk of diabetes

Heart rate measures could identify individuals with higher risk of diabetes

An association between resting heart rate and diabetes suggests that heart rate measures could identify individuals with a higher future risk of diabetes, according to an international team of researchers. [More]
Splicing pattern of obesity, type 2 diabetes genes may contribute to pathophysiology of obesity

Splicing pattern of obesity, type 2 diabetes genes may contribute to pathophysiology of obesity

Alternative splicing of obesity and type 2 diabetes related genes may contribute to the pathophysiology of obesity, according to research from the University of Eastern Finland. Obesity leads to changes in the splicing pattern of metabolically relevant genes such as TCF7L2 and INSR, resulting in impaired insulin action. [More]
Continuous glucose monitoring using real-time CGM helps better manage diabetes

Continuous glucose monitoring using real-time CGM helps better manage diabetes

Patients with insulin-dependent diabetes can better control their HbA1c value with a combination of blood glucose self-monitoring (BGSM) and continuous interstitial glucose monitoring (CGM) using a real-time measurement device (real-time CGM) than with BGSM alone without severe or serious hypoglycaemia occurring more frequently. [More]
Hope For Heroes Foundation forms national alliance with USA Medical Card

Hope For Heroes Foundation forms national alliance with USA Medical Card

Hope For Heroes Foundation today announced the formation of a groundbreaking national alliance with USA Medical Card, a leading provider of free pharmacy discount cards. The new nationwide initiative benefiting Hope For Heroes will help fund programs that empower independence for our nation's disabled military veterans, police, firemen, and EMS professionals, and will help more people afford their prescriptions. [More]
Skipping meals linked to abdominal weight gain and diabetes risk in mice

Skipping meals linked to abdominal weight gain and diabetes risk in mice

The researchers assessed glucose production to check for insulin resistance in the mice that gorged and then fasted and found that they had indeed developed insulin resistance in their livers, which is an indicator of prediabetes... [More]
SARIL-RA-TARGET trial: Sarilumab meets co-primary efficacy endpoints in RA patients

SARIL-RA-TARGET trial: Sarilumab meets co-primary efficacy endpoints in RA patients

Regeneron Pharmaceuticals, Inc. and Sanofi announced today that a Phase 3 study of sarilumab, an investigational, fully human IL-6 receptor antibody, met its co-primary efficacy endpoints of a greater improvement in signs and symptoms of rheumatoid arthritis (RA) at 24 weeks and physical function at 12 weeks, compared to placebo. [More]
Novel drug target identified for treating rheumatoid arthritis

Novel drug target identified for treating rheumatoid arthritis

Researchers at the La Jolla Institute for Allergy and Immunology, in collaboration with colleagues the University of California, San Diego, identified a novel drug target for the treatment of rheumatoid arthritis that focuses on the cells that are directly responsible for the cartilage damage in affected joints. [More]
Researchers use American College of Cardiology registry to improve cardiovascular care delivery in India

Researchers use American College of Cardiology registry to improve cardiovascular care delivery in India

Despite challenges, it is feasible to collect and study the quality of outpatient cardiovascular care in a resource-limited environment like India, according to a pilot study published today in the Journal of the American Heart Association. [More]
Diabetes screening will overwhelm India’s health system, study predicts

Diabetes screening will overwhelm India’s health system, study predicts

The new study, which used mathematical models to simulate the outcome of screening the whole population, estimates that between 158 million and 306 million people would be referred for confirmatory testing, but only 26-37 million of those would meet the diagnostic criteria for diabetes... [More]
Study finds that nearly 35% of U.S. adults have metabolic syndrome

Study finds that nearly 35% of U.S. adults have metabolic syndrome

Nearly 35 percent of all U.S. adults and 50 percent of those 60 years of age or older were estimated to have the metabolic syndrome in 2011-2012, according to a study in the May 19 issue of JAMA. [More]
CWRU's Frances Payne Bolton School of Nursing receives grant to study multiple chronic conditions

CWRU's Frances Payne Bolton School of Nursing receives grant to study multiple chronic conditions

Case Western Reserve University's Frances Payne Bolton School of Nursing will begin training predoctoral and postdoctoral researchers to study people with multiple chronic illnesses in hopes of discovering better methods for managing such a complex combination of illnesses. [More]
Vitamin E helps build strong muscles

Vitamin E helps build strong muscles

Body builders have it right: vitamin E does help build strong muscles, and scientists appear to have figured out one important way it does it. [More]
vTv Therapeutics enrolls first patients in azeliragon Phase 3 trial for treatment of mild Alzheimer's disease

vTv Therapeutics enrolls first patients in azeliragon Phase 3 trial for treatment of mild Alzheimer's disease

vTv Therapeutics LLC today announced enrollment of the first patients into STEADFAST (Single Trial Evaluating Alzheimer's Disease Following Addition to Symptomatic Therapy), vTv's Phase 3 placebo controlled trial of azeliragon, an oral antagonist of the Receptor for Advanced Glycation Endproducts (RAGE) for treatment of mild Alzheimer's disease. [More]
Tandem Diabetes Care announces release of t:flex Insulin Pump

Tandem Diabetes Care announces release of t:flex Insulin Pump

Tandem Diabetes Care, Inc., a medical device company and manufacturer of the t:slim Insulin Pump, today announced that it is now taking orders for the t:flex Insulin Pump, with shipments planned to begin in June. The 480-unit t:flex Pump, cleared by the U.S. Food and Drug Administration in January 2015, is the largest capacity insulin pump currently offered in the United States. [More]
Type 2 diabetes screening followed by treatment could reduce risk of cardiovascular disease, death

Type 2 diabetes screening followed by treatment could reduce risk of cardiovascular disease, death

Screening to identify Type 2 diabetes followed by early treatment could result in substantial health benefits, according to new research published today in Diabetes Care that combined large scale clinical observations and innovative computer modelling. [More]
Pre-pregnancy maternal weight has significant impact on baby's immune system

Pre-pregnancy maternal weight has significant impact on baby's immune system

Almost 60 percent of women of childbearing age in the United States are overweight or obese. Obesity is a major public health issue, and has been linked to health problems like heart disease, cancer and hypertension. It can complicate pregnancy by increasing the mother's risk of having gestational diabetes, preeclampsia, preterm birth or a baby with birth defects. Maternal obesity is also linked to several adverse health outcomes for the infant that can persist into adulthood, such as type-2 diabetes, heart disease and mortality. [More]
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