This Novel Epigenetic Mechanism Defines an Entirely New Class of Therapeutic
Resverlogix Corp. ("Resverlogix" or the "Company") (TSX:RVX) today announces the "Mechanism of Action" (MoA) by which RVX-208 increases apolipoprotein A-I (ApoA-I) production. Our data shows RVX-208 to be an inhibitor of the Bromodomain and Extraterminal Domain (BET) proteins. RVX-208 acts on BET proteins, including BRD4, a member of the BET-protein family, leading to increased transcription of the ApoA-I gene followed by production of more ApoA-I protein.
ApoA-I is the major protein component of HDL, a class of lipoproteins believed to reduce atherosclerosis through reverse cholesterol transport (RCT). The ability of RVX-208 to increase ApoA-I makes it the lead candidate in Resverlogix' pipeline for treating atherosclerotic cardiovascular disease. RVX-208 is an orally active small molecule, the first in a new class of compounds to enter into human clinical trials more than 4 years ago. Clinical benefits of RVX-208 are currently being explored in two concurrent Phase 2b clinical trials (SUSTAIN and ASSURE), led by Cleveland Clinic.