Study unravels mechanisms by which saffron-based crocin prevents liver cancer

Liver cancer remains among the leading causes of cancer-related death worldwide. New study lead by UAE University Prof. Amr Amin unravels mechanisms by which saffron-based 'crocin' protects against liver cancer. The study entitled 'Saffron-Based Crocin Prevents Early Lesions of Liver Cancer: In Vivo, In Vitro and Network Analyses' is funded by Al-Jalila Foundation & Terry Fox Foundation and is published in Recent Patents on Anticancer Drug Discovery. Using murine model, human liver cancer cells, gene expression profiling and computer-assisted modeling analyses, Amin's study identifies NF-kB as a regulatory hub and a candidate therapeutic drug target for liver cancer.