T cells have an important role in the adaptive immune response. The binding of the T cell receptor (TCR) in naive T cells to peptides complexed with major histocompatibility complex (MHC) generates a detailed signaling mechanism resulting in T cell activation, proliferation and the creation of cytokines.
Using genetic engineering, small molecules, or biologics to modulate the TCR signaling pathway is highly applicable to a range of therapeutic fields such as autoimmune diseases, vaccine development, adoptive cell therapy, and cancer immunotherapy.
The frequent use of assays to outline health and T cell function is vital for the advancement of these therapies and drugs. Sartorius has produced a high throughput, optimized flow cytometry assay to quantify T cell activation to meet the demand for efficient monitoring of immune cell function.
The T Cell Activation Cell and Cytokine Profiling Kit makes the conventional workflow more efficient by measuring T cell activation markers, cell phenotype, cell viability, cell proliferation and by quantitating secreted cytokines in one 10 ul sample utilizing a miniaturized multi-well plate format.
About Sartorius
The Sartorius Group is a leading international partner of biopharmaceutical research and the industry. With innovative laboratory instruments and consumables, the Group's Lab Products & Services Division concentrates on serving the needs of laboratories performing research and quality control at pharma and biopharma companies and those of academic research institutes. The Bioprocess Solutions Division with its broad product portfolio focusing on single-use solutions helps customers to manufacture biotech medications and vaccines safely and efficiently.”
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