Cell Adhesion News and Research

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Counting immune cells on a 'protein printboard'

In order to monitor how far an HIV infection has progressed, the number of immune cells - lymphocytes - must be counted. Researchers at the University of Twente have developed a method that neatly arranges the antibodies that bind to these immune cells on a 'molecular printboard'. The researchers are publishing this key step in the road towards antibody-based sensors in the Journal of the American Chemical Society (JACS).

20 May 2008

Australian scientists use gene technology to improve IVF treatment

Research by a team of Australian scientists promises to improve the fertility treatment in vitro fertilisation (IVF).

15 May 2008

Aggregates of red and white blood cells may contribute to sickle cell disease

It's long been known that patients with sickle cell disease have malformed, "sickle-shaped" red blood cells - which are normally disc-shaped - that can cause sudden painful episodes when they block small blood vessels.

28 Apr 2008

A diaphanous control during embryo formation

The research now published in the journal Development shows how Dia mutations in fruit flies embryos result in a serious of defects during morphogenesis (process by which cells differentiate into tissues and structures), including loss of adhesion, abnormal movements and even migration of cells from one tissue to another.

9 Apr 2008

MicroRNAs, EMT and cancer progression

In the April 1 issue of G&D, a research team led by Dr. Marcus Peter (University of Chicago) identifies the microRNA miR-200 as both a powerful indicator and regulator of the epithelial phenotype of cancer cells.

1 Apr 2008

Disruption of the Contactin 4 gene on chromosome 3 may be linked to autism spectrum disorder

Eli Hatchwell, M.D., Ph.D., Associate Professor of Pathology at Stony Brook University Medical Center, and colleagues have found that a disruption of the Contactin 4 gene on chromosome 3 may be linked to autism spectrum disorder (ASD).

20 Mar 2008

Nuclear protein SATB1 triggers aggressive breast cancer

SATB1 is a nuclear protein well known for its crucial role in regulating gene expression during the differentiation and activation of T cells, making it a key player in the immune system.

13 Mar 2008

New large-scale method reveals drug targets

Wellcome Trust Sanger Institute scientists have developed a new large-scale method to identify the interactions between proteins that are a major target for therapeutic intervention.

26 Feb 2008

Scientists find new cellular receptor for HIV

A cellular protein that helps guide immune cells to the gut has been newly identified as a target of HIV when the virus begins its assault on the body's immune system, according to researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).

11 Feb 2008

Brain molecule from endothelial cells may be a new target for treatment of multiple sclerosis

In the February issue of Nature Immunology, the team provides fresh answers concerning the role of novel adhesion molecules in the pathogenesis of MS, a chronic autoimmune disease of the nervous system that affects approximately 55,000 young adults in Canada.

23 Jan 2008

Closest look ever at native human tissue

Seeing proteins in their natural environment and interactions inside cells has been a long-standing goal.

5 Dec 2007

Discovery of 300 previously unidentified human genes

Using supercomputers to compare portions of the human genome with those of other mammals, researchers at Cornell have discovered some 300 previously unidentified human genes, and found extensions of several hundred genes already known.

21 Nov 2007

Does neural cell adhesion molecule-180 predict survival in colorectal cancer?

When a person learns they are suffering from cancer, the first question in their mind is always: "How much time do I have?" Unfortunately, this is a question to which the researchers have long been seeking an absolute answer.

5 Nov 2007

Researchers develop mouse model of autism spectrum disorders

Howard Hughes Medical Institute researchers have genetically engineered mice that harbor the same genetic mutation found in some people with autism and Asperger syndrome.

10 Sep 2007

Brain function is even more impaired in cirrhotic than non-cirrhotic alcoholics

Sustained exposure to alcohol can cause scarring and dysfunction of the liver, referred to as cirrhosis.

28 Aug 2007

How cells change the pace of their steps

Scientists at UC San Diego have discovered how cells of higher organisms change the speed at which they move, a basic biological discovery that may help researchers devise ways to prevent cancer cells from spreading throughout the body.

7 Aug 2007

Effects of aging hematopoietic stem cells

There is little disagreement that the body's maintenance and repair systems deteriorate with age, even as there is plenty of disagreement as to why.

24 Jul 2007

Scientists discover a new line of communication between nervous system cells

In a host of neurological diseases, including multiple sclerosis (MS) and several neuropathies, the protective covering surrounding the nerves - an insulating material called myelin - is damaged.

27 Jun 2007

New insight into the mechanism by which glial cells recognize and myelinate axons

In a host of neurological diseases, including multiple sclerosis (MS) and several neuropathies, the protective covering surrounding the nerves - an insulating material called myelin - is damaged.

27 Jun 2007

New contributor to aggressive cancers

Mutations in the cell adhesion molecule known as integrin alpha 7 (integrin 7) lead to unchecked tumor cell proliferation and a significantly higher incidence in cancer spread, or metastasis, in several cancer cell lines, report researchers at the University of Pittsburgh School of Medicine in a study published in the Journal of the National Cancer Institute.

8 Jun 2007