Gastrointestinal Health

This hub offers a comprehensive resource on gastrointestinal health, digestive diseases, and the human microbiome, drawing together authoritative articles on basic science, clinical management, and emerging research. The collection addresses the pathophysiology, diagnosis, and treatment of major gastrointestinal disorders, including irritable bowel syndrome, celiac disease, inflammatory bowel disease, and gastroesophageal reflux, while also exploring surgical, dietary, and pharmacological interventions. Special emphasis is given to the role of the gut microbiome in health and disease, including its influence on immunity, metabolism, neurological function, and response to therapy. Readers will also find up-to-date insights into microbiome-related interventions, such as fecal microbiota transplantation, as well as practical guidance for dietary management and prevention. This hub serves as a trusted reference for clinicians, researchers, and individuals seeking an evidence-based understanding of digestive and microbiome science.

Can you Treat a Food Allergy by Altering the Gut Microbiome?

There is a relationship between gut microbiome and allergy which may allow some children to outgrow their food allergy.

Human Microbiome Project (HMP)

How Does the Diet Impact Microbiota?

Self-Help for Irritable Bowel Syndrome (IBS)

Inflammatory Bowel Disease and Colorectal Cancer

Genetic Factors that Influence Bacterial Diversity in the Human Gut

Risk Factors for Small Intestinal Bacterial Overgrowth

What is Gastrointestinal Bleeding?

Disease Susceptibility and the Microbiome

Fecal Microbiota Transplant Regulation

Causes of Bleeding in the Upper and Lower Gastrointestinal Tract

Gastroparesis Symptoms

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Skin Microbiota

Irritable Bowel Syndrome (IBS) Research

Gastroparesis Epidemiology

Treatment and Prognosis for Intestinal Malrotation

What is a Gastric Bypass?

Gastrointestinal Disease and Skin Problems

After Gastric Bypass Surgery

Do Serotonin and Antidepressants Affect the Microbiome?

Gastric Bypass Benefits

FODMAP Research

Gut-on-a-Chip to Model Coeliac Disease

Symptoms of Irritable Bowel Syndrome

The Microbiome and Aging

Irritable Bowel Syndrome (IBS) and Stress Response

Irritable Bowel Syndrome (IBS) and Infections

Gastrointestinal Bleeding Treatment

Celiac Disease Pathogenesis

Gastroparesis Causes

Microbiome and Disease

Fecal Microbiota Transplant

Irritable Bowel Syndrome (IBS) and Exercise

Gastrointestinal Stromal Tumor (GIST) Treatment

Does the Microbiome Interact with the Human Endocrine System?

Malrotation of the Gastrointestinal Tract

What is Gastroschisis?

Causes of Irritable Bowel Syndrome

What does Sleeve Gastrectomy Involve?

Gastrointestinal Stromal Tumor (GIST) Signs and Symptoms

Gastric Bypass Complications

Gastric Varices

Is Dermatitis Herpetiformis Caused by Herpes?

Gastrointestinal Stromal Tumor (GIST) Causes

Dermatitis Herpetiformis and Celiac Disease

Mechanism of Irritable Bowel Syndrome (IBS)

Parkinson's Disease and the Gut Microbiome

Sarin Classification of Gastric Varices

Is There a Link Between Migraine and the Gut Microbiome?

What is Gastroenteritis?

Irritable Bowel Syndrome (IBS) Prognosis

Drug Metabolism and Microbiome

Irritable Bowel Syndrome (IBS) Food Triggers

Ulcerative Colitis Causes

Dysbiosis and the Microbiome

What is Vaginal Microbiome?

Gastroparesis Treatments

Irritable Bowel Syndrome (IBS) Epidemiology

Gastritis Diagnosis

Treatment of Gastro-Esophageal Reflux Disease (GERD)

What is Gastritis?

Post-Infectious Irritable Bowel Syndrome

Achievements of the Human Microbiome Project

Symptoms of Gastro-Esophageal Reflux Disease (GERD)

Gastritis Causes

What is Gluten?

Gastroparesis and Diet

Gastrointestinal Stromal Tumor (GIST) Diagnosis

Oral Microbiota

Celiac Disease Diagnosis

How to Recover Gut Health After Clostridium difficile Infection

Effects of a Gluten-Free Diet on the Gut Microbiota

Diabetic Gastroparesis

Gastroschisis Causes

Conjunctiva microbiota

Treatment of Irritable Bowel Syndrome

Low FODMAP Diet

What is Irritable Bowel Syndrome?

Irritable Bowel Syndrome (IBS) Differential Diagnosis

Genetics of Inflammatory Bowel Disease (IBD)

What is Celiac Disease?

ERCP (Endoscopic Retrograde Cholangiopancreatography) Overview

Gastroschisis Prognosis

Irritable Bowel Syndrome (IBS) and Diet

Celiac Disease Treatment

Gastric Bypass Criteria

Fecal Microbiota Transplant Technique

Irritable Bowel Syndrome (IBS) Psychological Therapies

Types of Gastrectomy

Celiac Disease Symptoms

Antibiotics and the Microbiome

Fermented Foods and Gut Health

Gastritis Treatments

Irritable Bowel Syndrome (IBS) Comorbidities

Functional Gastrointestinal Disorders: Integrating Physiological and Psychological Approaches

Symptoms and Diagnosis of Intestinal Malrotation

Gastroparesis Diagnosis

What is Gastroenterology?

Irritable Bowel Syndrome (IBS) and Psychiatric Illness

Dysbiosis and Aging

Irritable Bowel Syndrome (IBS) and Fibromyalgia

Microbiome-Host Cell Interactions

Gastric Varices - Signs and Symptoms

Diagnosis of Gastro-Esophageal Reflux Disease (GERD)

What is Gastroparesis?

Gastric Carcinoma

Microbiome and Cancer

Gastrointestinal Bleeding Symptoms

Gut Microbiota

Probiotics and IBS

Diagnosis of Irritable Bowel Syndrome

Does Wheat Cause Gut Inflammation?

Inflammatory Bowel Disease (IBD) in Pregnancy

Human Microbiome

Causes of Gastro-Esophageal Reflux Disease (GERD)

Gastritis Symptoms

Crohn's Disease Cause

Celiac Disease Screening

Treatment of Gastric Varices

Gastric Bypass Types

Short-Chain Fatty Acids (SCFAs)

Gastrointestinal Stromal Tumor Pathogenesis

Alzheimer's Disease and the Microbiome

High FODMAP Foods and Low FODMAP Food Alternatives

FODMAPs and Irritable Bowel Syndrome (IBS)

What is Ulcerative Colitis?

Mesentery: a new organ?

Latest Gastrointestinal Health News and Research

How Traditional Chinese Medicine may reshape the gut microbiome to ease insulin resistance in PCOS

This review synthesizes evidence that gut microbiota dysbiosis contributes to insulin resistance and symptom severity in polycystic ovary syndrome through impaired barrier function, inflammation, and altered microbial metabolites. It evaluates how Traditional Chinese Medicine may modulate these pathways while highlighting major gaps in clinical validation, safety, and standardization.

16 Dec 2025

Specific gut bacterium reduces weight gain and improves metabolic health

The gut microbiome is intimately linked to human health and weight. Differences in the gut microbiome-the bacteria and fungi in the gut-are associated with obesity and weight gain, raising the possibility that changing the microbiome could improve health.

16 Dec 2025

Frog-derived bacteria offer dual-action anticancer effects and high safety

A research team of Prof. Eijiro Miyako at the Japan Advanced Institute of Science and Technology (JAIST) has discovered that the bacterium Ewingella americana, isolated from the intestines of Japanese tree frogs (Dryophytes japonicus), possesses remarkably potent anticancer activity. This groundbreaking research has been published in the international journal Gut Microbes.

16 Dec 2025

Fructans and ATIs impact digestive health in beer

The GLUTEN3S research group of the University of the Basque Country (EHU) has identified the presence of fructans and amylase/trypsin inhibitor (ATI) proteins in gluten-free beers made from barley, compounds that can cause digestive symptoms in sensitive individuals. Its content is comparable to that of traditional beers containing gluten, according to a study published in the Journal of Food Composition and Analysis.

16 Dec 2025

Scientists map how cinnamon’s bioactives interact with cancer signaling

This review synthesizes preclinical evidence showing that cinnamon-derived compounds can modulate inflammation, oxidative stress, apoptosis, and angiogenesis through multiple cancer-related signaling pathways. While biologically plausible, the findings are largely limited to cell and animal models, underscoring the need for pharmacokinetic, safety, and clinical validation.

15 Dec 2025

Gut bacteria patterns differ in autism and siblings and link to social symptoms

This sibling-controlled East Asian study found that autistic individuals, their unaffected siblings, and typically developing controls differ in gut microbiota diversity and composition, with the clearest separation between autism and typical development. Specific taxa, particularly the butyrate-producing genus Anaerostipes, were modestly associated with social communication and internalising symptoms, supporting a gut–behaviour link without implying causality.

15 Dec 2025

Advances in delivering oxygen-sensitive gut bacteria improve microbial therapies

Recent research has identified practical ways to protect and deliver oxygen-sensitive gut bacteria for a path toward safer, standardized microbial therapies that could reduce reliance on donor-based faecal microbiota transplants.

15 Dec 2025

What drinking kefir really does to your gut and oral microbiome

The impact of kefir on gut and oral microbiomes shows promise, but inconsistent findings and study limitations call for more rigorous scientific investigation.

15 Dec 2025

Understanding how the immune system protects against fungal pathogenicity

The yeast Candida albicans colonizes mucosal surfaces and is usually harmless. However, under certain conditions it can cause dangerous infections.

15 Dec 2025

Gut bacteria mimicry can accelerate the progression of multiple sclerosis

If gut bacteria are too similar to the protective layer of nerves, they can misdirect the immune system and cause it to attack its own nervous system.

15 Dec 2025

Unnecessary gluten-free diets may put children at risk

Understanding gluten-related disorders is crucial for pediatric nutrition, as gluten-free diets can pose health risks without appropriate medical supervision.

15 Dec 2025

A new trial investigates whether the MIND diet can be scaled for obesity management

This study protocol outlines a 12-week randomized trial testing whether a MIND diet intervention is feasible, acceptable, and sustainable for adults with obesity in Sweden. It will generate preliminary evidence on adherence, mental well-being, and gut microbiota changes to inform larger efficacy trials.

14 Dec 2025

Researchers develop powerful tools for microbiome research advancement

The microscopic organisms that fill our bodies, soils, oceans and atmosphere play essential roles in human health and the planet's ecosystems. Yet even with modern DNA sequencing, figuring out what these microbes are and how they are related to one another remains extremely difficult.

13 Dec 2025

Mass General Brigham launches AI company to enhance clinical trial matching

Mass General Brigham is announcing the spinout of AIwithCare, a company founded by researchers from the health system who developed an artificial intelligence (AI) screening tool that significantly outperformed manual screening for determining a patient's eligibility and enrolling them in a clinical trial.

12 Dec 2025

Fear strongly influences pain perception in inflammatory bowel disease patients

Pain perception in affected individuals is more strongly influenced by learned fear than in healthy individuals. Changes along the gut-brain axis related to chronic inflammation may explain this.

12 Dec 2025

How ultra-processed foods shape Crohn’s disease risk and what dietary strategies can really help

This narrative review synthesizes evidence showing that higher intake of ultra-processed foods is consistently associated with increased Crohn’s disease risk, with mechanistic pathways implicating emulsifiers, carrageenan, maltodextrin, titanium dioxide, sweeteners and salt. It also highlights that minimally processed dietary strategies, including EEN and CDED, show therapeutic promise, particularly in pediatric Crohn’s disease.

11 Dec 2025

White bread vs wholegrain: which one is actually better for your health?

This review dispels common myths about white and wholegrain bread by examining their composition processing and health effects. It concludes that while wholegrain breads offer added benefits white bread remains a safe affordable and nutritionally meaningful staple when fortified.

11 Dec 2025

Discovery links human M cells to early steps of celiac disease

The human small intestine absorbs nutrients while protecting us from potentially harmful microbes. One of the cell types that plays a key role in this protection is the microfold cell, or M cell.

10 Dec 2025

Why the form of vitamin B12 you take may matter more than your intake

This comprehensive review examines vitamin B12 absorption, physiological roles, deficiency states, and dietary sources, with particular attention to differences between natural and synthetic forms. The authors conclude that while all B12 forms raise circulating levels, methylcobalamin may offer advantages in specific clinical contexts, especially where absorption or metabolic conversion is impaired.

10 Dec 2025

Filtered coffee shows a causal link to healthier HbA1c levels

Genetically predicted filtered coffee consumption is causally associated with lower HbA1c levels, while other coffee preparation methods show no such benefit. This effect appears to be partly mediated by increases in propionate producing gut bacteria, particularly Veillonella.

10 Dec 2025