Gastrointestinal Health

This hub offers a comprehensive resource on gastrointestinal health, digestive diseases, and the human microbiome, drawing together authoritative articles on basic science, clinical management, and emerging research. The collection addresses the pathophysiology, diagnosis, and treatment of major gastrointestinal disorders, including irritable bowel syndrome, celiac disease, inflammatory bowel disease, and gastroesophageal reflux, while also exploring surgical, dietary, and pharmacological interventions. Special emphasis is given to the role of the gut microbiome in health and disease, including its influence on immunity, metabolism, neurological function, and response to therapy. Readers will also find up-to-date insights into microbiome-related interventions, such as fecal microbiota transplantation, as well as practical guidance for dietary management and prevention. This hub serves as a trusted reference for clinicians, researchers, and individuals seeking an evidence-based understanding of digestive and microbiome science.

Can you Treat a Food Allergy by Altering the Gut Microbiome?

There is a relationship between gut microbiome and allergy which may allow some children to outgrow their food allergy.

Dysbiosis and the Microbiome

How Does the Diet Impact Microbiota?

Functional Gastrointestinal Disorders: Integrating Physiological and Psychological Approaches

Gastroschisis Causes

Probiotics and IBS

Irritable Bowel Syndrome (IBS) Research

Gastroparesis Epidemiology

Causes of Irritable Bowel Syndrome

Celiac Disease Diagnosis

Gastrointestinal Stromal Tumor (GIST) Causes

Genetic Factors that Influence Bacterial Diversity in the Human Gut

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Does the Microbiome Interact with the Human Endocrine System?

What is Vaginal Microbiome?

Gastritis Diagnosis

Causes of Gastro-Esophageal Reflux Disease (GERD)

Types of Gastrectomy

Microbiome and Cancer

Self-Help for Irritable Bowel Syndrome (IBS)

Skin Microbiota

Celiac Disease Screening

Irritable Bowel Syndrome (IBS) Prognosis

Irritable Bowel Syndrome (IBS) and Exercise

What does Sleeve Gastrectomy Involve?

Irritable Bowel Syndrome (IBS) and Diet

Gastric Carcinoma

Effects of a Gluten-Free Diet on the Gut Microbiota

FODMAP Research

Post-Infectious Irritable Bowel Syndrome

Is Dermatitis Herpetiformis Caused by Herpes?

Is There a Link Between Migraine and the Gut Microbiome?

What is Gastroenterology?

Inflammatory Bowel Disease and Colorectal Cancer

Human Microbiome

Conjunctiva microbiota

Achievements of the Human Microbiome Project

Genetics of Inflammatory Bowel Disease (IBD)

Irritable Bowel Syndrome (IBS) Comorbidities

Gastrointestinal Stromal Tumor (GIST) Treatment

Malrotation of the Gastrointestinal Tract

Dysbiosis and Aging

Gastroparesis Symptoms

Alzheimer's Disease and the Microbiome

Gastroparesis Diagnosis

Antibiotics and the Microbiome

Oral Microbiota

Treatment of Gastro-Esophageal Reflux Disease (GERD)

Treatment and Prognosis for Intestinal Malrotation

Symptoms of Gastro-Esophageal Reflux Disease (GERD)

Treatment of Irritable Bowel Syndrome

Low FODMAP Diet

Gastric Bypass Criteria

Irritable Bowel Syndrome (IBS) and Stress Response

Inflammatory Bowel Disease (IBD) in Pregnancy

Gastrointestinal Bleeding Symptoms

Irritable Bowel Syndrome (IBS) Psychological Therapies

Gastroschisis Prognosis

Microbiome and Disease

Gastrointestinal Disease and Skin Problems

Gastric Bypass Benefits

Gut-on-a-Chip to Model Coeliac Disease

Disease Susceptibility and the Microbiome

Irritable Bowel Syndrome (IBS) and Fibromyalgia

What is Gastroparesis?

Fecal Microbiota Transplant Technique

Sarin Classification of Gastric Varices

Gastrointestinal Stromal Tumor (GIST) Diagnosis

Gastroparesis Treatments

What is Gluten?

Gastroparesis Causes

Irritable Bowel Syndrome (IBS) Differential Diagnosis

What is Irritable Bowel Syndrome?

Mechanism of Irritable Bowel Syndrome (IBS)

Gastric Varices - Signs and Symptoms

Irritable Bowel Syndrome (IBS) Food Triggers

Symptoms and Diagnosis of Intestinal Malrotation

Gut Microbiota

Diagnosis of Gastro-Esophageal Reflux Disease (GERD)

Celiac Disease Symptoms

FODMAPs and Irritable Bowel Syndrome (IBS)

Celiac Disease Pathogenesis

Irritable Bowel Syndrome (IBS) and Infections

Drug Metabolism and Microbiome

After Gastric Bypass Surgery

Crohn's Disease Cause

High FODMAP Foods and Low FODMAP Food Alternatives

Gastritis Treatments

Fermented Foods and Gut Health

Gastric Bypass Complications

Gastroparesis and Diet

Celiac Disease Treatment

What is a Gastric Bypass?

What is Celiac Disease?

Ulcerative Colitis Causes

ERCP (Endoscopic Retrograde Cholangiopancreatography) Overview

Human Microbiome Project (HMP)

Diabetic Gastroparesis

Irritable Bowel Syndrome (IBS) and Psychiatric Illness

Treatment of Gastric Varices

What is Gastroenteritis?

What is Gastrointestinal Bleeding?

How to Recover Gut Health After Clostridium difficile Infection

Gastric Bypass Types

Gastritis Symptoms

What is Ulcerative Colitis?

Diagnosis of Irritable Bowel Syndrome

Gastric Varices

Gastrointestinal Stromal Tumor (GIST) Signs and Symptoms

Does Wheat Cause Gut Inflammation?

What is Gastritis?

Mesentery: a new organ?

Risk Factors for Small Intestinal Bacterial Overgrowth

The Microbiome and Aging

Fecal Microbiota Transplant

Short-Chain Fatty Acids (SCFAs)

Fecal Microbiota Transplant Regulation

Do Serotonin and Antidepressants Affect the Microbiome?

What is Gastroschisis?

Gastritis Causes

Gastrointestinal Bleeding Treatment

Symptoms of Irritable Bowel Syndrome

Causes of Bleeding in the Upper and Lower Gastrointestinal Tract

Gastrointestinal Stromal Tumor Pathogenesis

Irritable Bowel Syndrome (IBS) Epidemiology

Dermatitis Herpetiformis and Celiac Disease

Microbiome-Host Cell Interactions

Parkinson's Disease and the Gut Microbiome

Latest Gastrointestinal Health News and Research

Disrupting three Salmonella genes weakens bacterial biofilm defenses

A major challenge to combating bacterial infections is the formation of biofilms-protective structures that allow bacteria to adhere to surfaces and reproduce, increasing their chances of survival even when challenged with antibiotics and the host's immune system.

4 Nov 2026

AlphaFold3 reveals molecular interactions driving T cell recognition

Researchers at the Translational Genomics Research Institute (TGen), part of City of Hope, have developed a new approach using the artificial intelligence platform AlphaFold3 to predict whether a T cell receptor will recognize a specific antigen based solely on its genetic sequence.

3 Nov 2026

Engineered beneficial bacteria reduce bloodstream infections after stem cell transplants

Researchers at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the country, and collaborators have pioneered a new approach to preventing dangerous bloodstream infections in patients receiving donor stem cell transplants for blood cancers.

3 Nov 2026

Study reveals how breast milk sugar may help protect infants against jaundice

A new study by researchers at the University of California San Diego School of Medicine sheds light on the role of breast milk in supporting intestinal development and preventing hyperbilirubinemia, a condition in which bilirubin, a waste product from broken-down red blood cells, builds up in the blood and causes yellowing of the skin and eyes known as jaundice.

3 Nov 2026

Compounds that give citrus fruits their scent may affect gut health

A review published in Food & Function found that dietary terpenoids, naturally occurring compounds in fruits, herbs, and vegetables, can suppress inflammatory signalling and improve intestinal barrier function in laboratory and animal studies. However, human evidence remains limited to two small studies of geraniol-based interventions for irritable bowel syndrome, with further research needed to establish clinical efficacy, appropriate dosing, and long-term safety.

3 Nov 2026

Blueberries reduced blood vessel inflammation in mice, but only with gut microbes present

A preclinical study found that gut microbes help convert blueberry phytochemicals into circulating metabolites, including hippuric acid, that are associated with reduced vascular inflammation. In mice fed a high-fat diet, blueberry supplementation reduced inflammatory markers and monocyte adhesion to blood vessels, but these benefits disappeared following antibiotic-mediated gut microbial depletion.

3 Nov 2026

New enzyme discovery reveals how breast milk feeds infant gut bacteria

Microbiologists have found that an enzyme, not normally associated with microbial activities in the human gut, to have a role in how some bacteria access key nutrients in breast milk.

3 Nov 2026

Gene therapy successfully corrects genetic defect in alpha-1 antitrypsin deficiency

In a landmark achievement in the field of genetic medicine, researchers have reported the very first published case in a peer-reviewed journal of a successful clinical treatment of a patient with alpha-1 antitrypsin deficiency (PiZZ) using in vivo gene therapy.

2 Nov 2026

Spatial study maps active epithelial crosstalk driving chronic periodontitis

Epithelial barriers are active organizers of tissue homeostasis, immune surveillance and host defense, yet chronic inflammation can corrupt their repair and communication with connective tissue.

2 Nov 2026

Aspirin fails to prevent recurrence after surgery for colorectal cancer liver metastases

Colorectal cancer is one of the most common cancers in Norway, which also has one of the highest incidence rates in the world.

2 Nov 2026

Study finds unexpected lower gut bacterial diversity in vegans

The gut is home to billions of microorganisms. It is a complex ecosystem that regulates many of the body's functions and helps keep us healthy – when it is in balance.

30 Oct 2026

Gut microbial catalog reveals systemic inflammation drivers in spinal injury

Scientists exploring the links between a spinal cord injury, inflammation and immune function have turned their attention to a genome-level analysis of the gut microbial community, with early study results offering hints at potential new approaches to aid healing.

30 Oct 2026

Study redefines picobirnavirus as a bacteria hunting virus

Thriving alongside trillions of bacteria in the human digestive tract is a vast population of viruses. Ever since one such denizen of the gut microbiome, known as picobirnavirus, was first spotted decades ago, researchers thought it directly infected human tissue and played a role in gastrointestinal illness.

29 Oct 2026

New host target identified to block hepatitis E virus

Hepatitis E virus (HEV) is a major cause of acute viral hepatitis, yet antiviral treatment remains largely limited to the off-label use of ribavirin. Ribavirin can cause substantial toxicity, is contraindicated during pregnancy and does not reliably benefit every patient.

29 Oct 2026

New Yale initiative explores the role of inflammation in disease

Yale School of Medicine (YSM) was awarded a $10 million grant from the Blavatnik Family Foundation (BFF) to launch a new research initiative in the field of inflammation science.

29 Oct 2026

Researchers tested an unexpected addition to vaginal treatment: oxygen

Researchers investigated the effects of topical vaginal oxygen treatment, alone or combined with antimicrobials, on the vaginal microbiota of 22 women with bacterial vaginosis or vaginitis. The combined treatment reduced the relative abundance of strict anaerobes and increased Lactobacillus abundance, but the absence of an antimicrobial-only control group prevented researchers from establishing whether oxygen contributed independently to these changes.

28 Oct 2026

New score predicts thrombosis risk in hospitalized pancreatitis patients

Professor Julia Mayerle and colleagues from LMU University Hospital Munich have developed an admission-based score intended to identify pancreatitis patients more likely to be diagnosed with thrombosis during hospitalization.

28 Oct 2026

Semaglutide changes gut bacteria in rats beyond what eating less explains

Researchers compared semaglutide-treated male and female rats with pair-fed animals receiving the same amount and type of food to distinguish drug-associated microbiome changes from those linked to reduced eating. Semaglutide altered bacterial richness and community composition, with some changes absent from the pair-fed groups and uncertain consequences for health.

26 Oct 2026

Beer and liquor show more oral bacteria links than wine in a large US study

Researchers analyzed beverage intake and oral microbiome data from 5,598 adults across three US cohorts and found that alcohol consumption showed the strongest associations with oral bacterial diversity and composition among the beverages examined. Higher alcohol intake was associated with greater bacterial richness and differences in genera linked to oral health, but the cross-sectional preprint could not establish whether alcohol caused these differences or influenced disease risk.

26 Oct 2026

The vaginal microbiome may relate to more than reproductive health

Researchers analyzed vaginal microbiota, metabolites, and psychological questionnaire scores in 105 young Italian women and found associations between microbial community types and reward responsiveness, motivational drive, and behavioral inhibition. Exploratory models identified statistical links involving vaginal GABA and valine, but the cross-sectional study could not establish whether microbiome changes influence psychological functioning or the reverse.

26 Oct 2026