Gastrointestinal Health

This hub offers a comprehensive resource on gastrointestinal health, digestive diseases, and the human microbiome, drawing together authoritative articles on basic science, clinical management, and emerging research. The collection addresses the pathophysiology, diagnosis, and treatment of major gastrointestinal disorders, including irritable bowel syndrome, celiac disease, inflammatory bowel disease, and gastroesophageal reflux, while also exploring surgical, dietary, and pharmacological interventions. Special emphasis is given to the role of the gut microbiome in health and disease, including its influence on immunity, metabolism, neurological function, and response to therapy. Readers will also find up-to-date insights into microbiome-related interventions, such as fecal microbiota transplantation, as well as practical guidance for dietary management and prevention. This hub serves as a trusted reference for clinicians, researchers, and individuals seeking an evidence-based understanding of digestive and microbiome science.

Can you Treat a Food Allergy by Altering the Gut Microbiome?

There is a relationship between gut microbiome and allergy which may allow some children to outgrow their food allergy.

The Microbiome and Aging

Symptoms of Gastro-Esophageal Reflux Disease (GERD)

FODMAP Research

Gastric Bypass Criteria

Treatment of Irritable Bowel Syndrome

Celiac Disease Diagnosis

Celiac Disease Screening

Crohn's Disease Cause

Celiac Disease Treatment

Gastric Varices - Signs and Symptoms

Fecal Microbiota Transplant Regulation

See more featured articles »

Gastroparesis Epidemiology

After Gastric Bypass Surgery

Causes of Bleeding in the Upper and Lower Gastrointestinal Tract

What does Sleeve Gastrectomy Involve?

Microbiome and Disease

Gastrointestinal Stromal Tumor (GIST) Diagnosis

Gastrointestinal Bleeding Symptoms

Symptoms and Diagnosis of Intestinal Malrotation

Gastritis Causes

Treatment of Gastric Varices

What is Gastritis?

FODMAPs and Irritable Bowel Syndrome (IBS)

Dysbiosis and Aging

Does Wheat Cause Gut Inflammation?

Gastric Bypass Complications

Gastroparesis Treatments

What is Ulcerative Colitis?

Gastric Bypass Benefits

Dermatitis Herpetiformis and Celiac Disease

Is Dermatitis Herpetiformis Caused by Herpes?

Functional Gastrointestinal Disorders: Integrating Physiological and Psychological Approaches

Gastroparesis and Diet

ERCP (Endoscopic Retrograde Cholangiopancreatography) Overview

What is Gastroparesis?

Probiotics and IBS

Antibiotics and the Microbiome

Microbiome-Host Cell Interactions

Alzheimer's Disease and the Microbiome

Gastroschisis Prognosis

Diabetic Gastroparesis

Conjunctiva microbiota

Irritable Bowel Syndrome (IBS) Epidemiology

Gut Microbiota

How to Recover Gut Health After Clostridium difficile Infection

Do Serotonin and Antidepressants Affect the Microbiome?

Gastric Bypass Types

Irritable Bowel Syndrome (IBS) and Exercise

Gastritis Diagnosis

Irritable Bowel Syndrome (IBS) Research

Oral Microbiota

Genetics of Inflammatory Bowel Disease (IBD)

Gastritis Treatments

Gastroparesis Diagnosis

Skin Microbiota

What is Gastrointestinal Bleeding?

Mechanism of Irritable Bowel Syndrome (IBS)

Human Microbiome Project (HMP)

Causes of Irritable Bowel Syndrome

Diagnosis of Gastro-Esophageal Reflux Disease (GERD)

What is Celiac Disease?

Inflammatory Bowel Disease and Colorectal Cancer

Effects of a Gluten-Free Diet on the Gut Microbiota

How Does the Diet Impact Microbiota?

Gut-on-a-Chip to Model Coeliac Disease

Risk Factors for Small Intestinal Bacterial Overgrowth

Post-Infectious Irritable Bowel Syndrome

What is Gastroschisis?

Drug Metabolism and Microbiome

What is Vaginal Microbiome?

Human Microbiome

What is Gastroenteritis?

Fecal Microbiota Transplant

What is Irritable Bowel Syndrome?

Gastrointestinal Stromal Tumor (GIST) Signs and Symptoms

What is Gastroenterology?

Sarin Classification of Gastric Varices

Low FODMAP Diet

Gastrointestinal Disease and Skin Problems

Inflammatory Bowel Disease (IBD) in Pregnancy

Microbiome and Cancer

Fecal Microbiota Transplant Technique

Malrotation of the Gastrointestinal Tract

Symptoms of Irritable Bowel Syndrome

What is Gluten?

Irritable Bowel Syndrome (IBS) and Psychiatric Illness

Irritable Bowel Syndrome (IBS) and Infections

Mesentery: a new organ?

Gastric Carcinoma

Gastrointestinal Stromal Tumor (GIST) Treatment

Irritable Bowel Syndrome (IBS) and Stress Response

Fermented Foods and Gut Health

Disease Susceptibility and the Microbiome

Gastric Varices

Gastroparesis Causes

Treatment and Prognosis for Intestinal Malrotation

Gastrointestinal Stromal Tumor (GIST) Causes

Celiac Disease Pathogenesis

Is There a Link Between Migraine and the Gut Microbiome?

Celiac Disease Symptoms

Genetic Factors that Influence Bacterial Diversity in the Human Gut

Causes of Gastro-Esophageal Reflux Disease (GERD)

Gastrointestinal Bleeding Treatment

Irritable Bowel Syndrome (IBS) Psychological Therapies

Irritable Bowel Syndrome (IBS) Differential Diagnosis

Irritable Bowel Syndrome (IBS) Food Triggers

High FODMAP Foods and Low FODMAP Food Alternatives

Gastroschisis Causes

Treatment of Gastro-Esophageal Reflux Disease (GERD)

Dysbiosis and the Microbiome

Irritable Bowel Syndrome (IBS) and Fibromyalgia

Diagnosis of Irritable Bowel Syndrome

Does the Microbiome Interact with the Human Endocrine System?

What is a Gastric Bypass?

Irritable Bowel Syndrome (IBS) Prognosis

Achievements of the Human Microbiome Project

Gastritis Symptoms

Ulcerative Colitis Causes

Gastroparesis Symptoms

Parkinson's Disease and the Gut Microbiome

Types of Gastrectomy

Irritable Bowel Syndrome (IBS) Comorbidities

Short-Chain Fatty Acids (SCFAs)

Self-Help for Irritable Bowel Syndrome (IBS)

Irritable Bowel Syndrome (IBS) and Diet

Gastrointestinal Stromal Tumor Pathogenesis

Latest Gastrointestinal Health News and Research

Study sheds light on behavior of yeast cells in the gut

A new study sheds light on the behavior of yeast cells in the gut, paving the way for new lines of yeast that more efficiently produce therapeutic drugs tailored to address specific diseases.

24 Feb 2026

ATG14 found to be a critical defender against hepatic injury and fibrosis

Autophagy is indispensable for maintaining hepatocyte integrity, metabolic homeostasis, and survival. While several autophagy-related proteins have been studied in hepatic physiology, the specific role of Autophagy Related 14 (ATG14) in liver health has remained unclear.

24 Feb 2026

Indoor plants help create healthier, more climate-resilient buildings

Houseplants and more advanced plant systems, such as indoor living walls and hydroponic towers, have the potential to raise indoor humidity, boost thermal comfort and help create healthier, more climate-resilient buildings, according to new research led by the University of Surrey's Global Centre for Clean Air Research.

24 Feb 2026

Early exposure to unhealthy foods leaves lasting brain and feeding changes

Eating unhealthy foods early in life leave lasting brain and feeding changes but gut bacteria can help restore healthy eating, new University College Cork (UCC) research study finds today (Tuesday 24th February 10am)

24 Feb 2026

Colonoscopy and FIT at age 60 catch colorectal cancer earlier

The SCREESCO trial reveals that colorectal cancer screening at 60 enhances early diagnosis without affecting overall mortality or increasing long-term risks.

24 Feb 2026

New 3D liver reconstructions show how cirrhosis reshapes organ architecture

Never-before-seen 3D reconstructions of human liver tissue have been created at a cellular level. The details obtained by a team of UW Medicine and University of Washington engineers and physicians capture the spatial microstructure of multiple lobes of this multitasking organ.

23 Feb 2026

New review explores whether berries can slow cognitive decline linked to obesity

This systematic review in Nutrients evaluates human studies investigating whether polyphenol-rich berry consumption can modulate obesity-related metabolic dysfunction and support cognitive performance, particularly in individuals at risk of mild cognitive impairment. Evidence suggests modest memory benefits and possible metabolic improvements, although biomarker findings and long-term clinical relevance remain uncertain.

22 Feb 2026

Grant funds research on prenatal massage for maternal mental health

The Massage Therapy Foundation (MTF) announces the award of a research grant to University of Denver, Denver, Colo. The grant will support a three-year study entitled, "Prenatal Massage: A Complementary Approach for Maternal Health and Mental Health," led by Primary Investigator Galena Rhoades, PhD.

22 Feb 2026

Distinct gut toxicity patterns emerge with targeted cancer treatments

A new paper was published in Volume 13 of Oncoscience on February 6, 2026, titled "Gastrointestinal toxicity of targeted cancer therapies in the United States: Clinicopathologic patterns, FDA safety frameworks, and implications for national patient protection."

20 Feb 2026

Review: Natural selection can occur on multiple levels of biological organization

The common view of natural selection is based solely on the individual: A trait allows an organism to out-compete its rivals and is thus passed down to its offspring.

20 Feb 2026

Gut microbiome may shape response to GLP-1 drugs, new review suggests

This review examines how GLP-1 receptor agonists and the gut microbiome influence one another through bile acid signaling, short-chain fatty acids, and inflammatory pathways. It explores how microbial composition may shape treatment response and highlights the need for controlled human studies to enable microbiome-informed precision therapy.

19 Feb 2026

Gut bacteria patterns help predict insulin resistance in type 2 diabetes, study finds

Researchers used 16S rRNA sequencing and machine learning to identify gut microbiome patterns associated with insulin resistance severity in people with type 2 diabetes. XGBoost models showed that specific bacterial genera, including Bacteroides and Faecalibacterium, help distinguish individuals with higher insulin resistance from healthy controls.

19 Feb 2026

Cornell study finds existing drug could boost liver cancer immunotherapy

Immunotherapy – which activates the body's own immune system to kill cancer cells – has not worked well against a rare and fatal liver cancer, but a new Cornell University study finds an existing FDA-approved drug may allow the immunotherapy to fight the cancer as intended, opening the door to a potential treatment.

17 Feb 2026

AI tool can accurately predict colorectal cancer risk in UC-LGD patients

People with ulcerative colitis (UC), a chronic inflammatory bowel disease, are up to four times more likely to develop colorectal cancer than the general population.

17 Feb 2026

Study links microbe-rich diets with better insulin and cholesterol markers

This exploratory Australian study developed a database to estimate live microbe content in foods and examined associations with cardiometabolic health indicators in adults. Higher intake of foods estimated to contain live microbes was linked with favourable markers such as higher HDL cholesterol and lower BMI, insulin, and waist circumference, although causality cannot be inferred.

16 Feb 2026

Chronic inflammation shapes cancer progression and immunotherapy response

Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs, MDSCs, and Tregs-orchestrate a tumor-permissive microenvironment.

16 Feb 2026

Dysplasia grade predicts colorectal cancer risk in people with IBD

People with inflammatory bowel disease (IBD) and precancerous colorectal lesions are much more likely to develop colorectal cancer, a new study shows.

16 Feb 2026

Big breakfast study reveals protein curbs appetite but fiber delivers stronger gut microbiome benefits

A randomized crossover weight loss trial in adults with overweight or obesity found that higher protein big breakfasts improved satiety, while higher fibre breakfasts produced slightly greater weight loss and more favourable gut microbiota markers. Both diets improved metabolic biomarkers, but microbiota changes reflected surrogate gut health indicators rather than direct clinical outcomes.

15 Feb 2026

Engineered Listeria boosts innate immunity against cancer

After nearly 40 years of research on how Listeria bacteria manipulate our cells and battle our immune system to cause listeriosis, Daniel Portnoy and his colleagues have discovered a way to turn the bacteria into a potent booster of the immune system - and a potential weapon against cancer.

13 Feb 2026

Genetic variants in 11 regions of human genome influence the gut microbiome

In two new studies on 28,000 individuals, researchers are able to show that genetic variants in 11 regions of the human genome have a clear influence on which bacteria are in the gut and what they do there.

13 Feb 2026