Gastrointestinal Health

This hub offers a comprehensive resource on gastrointestinal health, digestive diseases, and the human microbiome, drawing together authoritative articles on basic science, clinical management, and emerging research. The collection addresses the pathophysiology, diagnosis, and treatment of major gastrointestinal disorders, including irritable bowel syndrome, celiac disease, inflammatory bowel disease, and gastroesophageal reflux, while also exploring surgical, dietary, and pharmacological interventions. Special emphasis is given to the role of the gut microbiome in health and disease, including its influence on immunity, metabolism, neurological function, and response to therapy. Readers will also find up-to-date insights into microbiome-related interventions, such as fecal microbiota transplantation, as well as practical guidance for dietary management and prevention. This hub serves as a trusted reference for clinicians, researchers, and individuals seeking an evidence-based understanding of digestive and microbiome science.

Can you Treat a Food Allergy by Altering the Gut Microbiome?

There is a relationship between gut microbiome and allergy which may allow some children to outgrow their food allergy.

What is Gastritis?

Treatment and Prognosis for Intestinal Malrotation

Mechanism of Irritable Bowel Syndrome (IBS)

Dermatitis Herpetiformis and Celiac Disease

Symptoms of Gastro-Esophageal Reflux Disease (GERD)

Celiac Disease Diagnosis

Malrotation of the Gastrointestinal Tract

Microbiome-Host Cell Interactions

Microbiome and Disease

Low FODMAP Diet

Skin Microbiota

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The Microbiome and Aging

Dysbiosis and the Microbiome

How to Recover Gut Health After Clostridium difficile Infection

Gastritis Diagnosis

Conjunctiva microbiota

Post-Infectious Irritable Bowel Syndrome

What is Irritable Bowel Syndrome?

Oral Microbiota

Ulcerative Colitis Causes

What is Vaginal Microbiome?

Gastric Bypass Criteria

Gastrointestinal Stromal Tumor (GIST) Causes

Irritable Bowel Syndrome (IBS) and Psychiatric Illness

Drug Metabolism and Microbiome

Risk Factors for Small Intestinal Bacterial Overgrowth

Fecal Microbiota Transplant Technique

What is Gastroschisis?

What does Sleeve Gastrectomy Involve?

Symptoms and Diagnosis of Intestinal Malrotation

Treatment of Gastro-Esophageal Reflux Disease (GERD)

Treatment of Gastric Varices

Fecal Microbiota Transplant Regulation

Gastritis Treatments

Celiac Disease Symptoms

Causes of Gastro-Esophageal Reflux Disease (GERD)

Achievements of the Human Microbiome Project

Genetics of Inflammatory Bowel Disease (IBD)

Fecal Microbiota Transplant

What is Gluten?

Effects of a Gluten-Free Diet on the Gut Microbiota

Irritable Bowel Syndrome (IBS) and Fibromyalgia

Irritable Bowel Syndrome (IBS) Food Triggers

Inflammatory Bowel Disease (IBD) in Pregnancy

Disease Susceptibility and the Microbiome

FODMAP Research

Irritable Bowel Syndrome (IBS) and Exercise

Antibiotics and the Microbiome

Irritable Bowel Syndrome (IBS) Comorbidities

Irritable Bowel Syndrome (IBS) and Infections

Celiac Disease Screening

Gastroparesis Treatments

Gastroparesis Causes

Causes of Bleeding in the Upper and Lower Gastrointestinal Tract

Does the Microbiome Interact with the Human Endocrine System?

Treatment of Irritable Bowel Syndrome

What is Gastroenterology?

Gastric Bypass Types

Is Dermatitis Herpetiformis Caused by Herpes?

Gastritis Symptoms

What is Celiac Disease?

Diagnosis of Irritable Bowel Syndrome

Irritable Bowel Syndrome (IBS) Research

Gastroparesis Epidemiology

Gastric Bypass Benefits

FODMAPs and Irritable Bowel Syndrome (IBS)

After Gastric Bypass Surgery

Gastritis Causes

What is Gastrointestinal Bleeding?

Gastroschisis Prognosis

Irritable Bowel Syndrome (IBS) and Diet

How Does the Diet Impact Microbiota?

Gastroschisis Causes

Inflammatory Bowel Disease and Colorectal Cancer

Gastroparesis Diagnosis

Celiac Disease Treatment

Irritable Bowel Syndrome (IBS) Epidemiology

Gastrointestinal Bleeding Treatment

Gastrointestinal Bleeding Symptoms

Irritable Bowel Syndrome (IBS) and Stress Response

Celiac Disease Pathogenesis

Do Serotonin and Antidepressants Affect the Microbiome?

Fermented Foods and Gut Health

Human Microbiome Project (HMP)

What is a Gastric Bypass?

What is Gastroparesis?

Gastrointestinal Disease and Skin Problems

Probiotics and IBS

Does Wheat Cause Gut Inflammation?

Short-Chain Fatty Acids (SCFAs)

Types of Gastrectomy

Sarin Classification of Gastric Varices

Self-Help for Irritable Bowel Syndrome (IBS)

Gastric Varices - Signs and Symptoms

Dysbiosis and Aging

ERCP (Endoscopic Retrograde Cholangiopancreatography) Overview

Microbiome and Cancer

Gastrointestinal Stromal Tumor (GIST) Signs and Symptoms

Symptoms of Irritable Bowel Syndrome

Diagnosis of Gastro-Esophageal Reflux Disease (GERD)

Gastrointestinal Stromal Tumor (GIST) Treatment

Irritable Bowel Syndrome (IBS) Psychological Therapies

Crohn's Disease Cause

Gastric Bypass Complications

What is Gastroenteritis?

Genetic Factors that Influence Bacterial Diversity in the Human Gut

Irritable Bowel Syndrome (IBS) Differential Diagnosis

Gastroparesis and Diet

Gut Microbiota

Is There a Link Between Migraine and the Gut Microbiome?

Gastrointestinal Stromal Tumor (GIST) Diagnosis

Parkinson's Disease and the Gut Microbiome

Gut-on-a-Chip to Model Coeliac Disease

Alzheimer's Disease and the Microbiome

Causes of Irritable Bowel Syndrome

Gastroparesis Symptoms

High FODMAP Foods and Low FODMAP Food Alternatives

Human Microbiome

Gastric Varices

Gastrointestinal Stromal Tumor Pathogenesis

Irritable Bowel Syndrome (IBS) Prognosis

Mesentery: a new organ?

Gastric Carcinoma

Functional Gastrointestinal Disorders: Integrating Physiological and Psychological Approaches

Diabetic Gastroparesis

What is Ulcerative Colitis?

Latest Gastrointestinal Health News and Research

Advanced tools and new leadership drive Single Cell Genomics Center into the future

Bigelow Laboratory for Ocean Sciences is excited to announce the appointment of new leadership - as well as new tools, analytical services, and a bold vision for the future - for the Single Cell Genomics Center.

2 Sep 2026

Bacterial protein fragment corisin found to drive pulmonary fibrosis

A bacterial protein fragment called corisin drives the process of pulmonary fibrosis by infiltrating and disrupting the cell's quality-control system, researchers at the University of Illinois Urbana-Champaign and Mie University in Japan found in a new study.

2 Sep 2026

Cellular atlas offers clues to childhood Crohn’s treatment response

Researchers have created a detailed map of childhood Crohn's disease before and after treatment to help understand progression of the disease.

1 Sep 2026

PCORI funding awarded to study symptom management for rare cholestatic liver diseases

The Patient-Centered Outcomes Research Institute (PCORI) has announced a $13 million funding award to the University of North Carolina at Chapel Hill over five years to study innovative symptom management interventions for patients with rare cholestatic liver diseases.

1 Sep 2026

Antifungal medication may reduce inflammatory bowel disease symptoms

A commonly used systemic antifungal medication may help reduce symptoms in a subset of patients with inflammatory bowel disease (IBD) by restoring a healthier gut microbiome, according to a preliminary study by Weill Cornell Medicine investigators.

1 Sep 2026

Study links human gut bacteria to levels of key chemicals in the brain

The neuroactive potential of bacteria living in the human gut is associated with levels of key chemicals in the brain, according to a new study from the University of Surrey and the University of Roehampton.

1 Sep 2026

Immunotherapy shows potential for treating rising gynecological tumors

Gynecological tumors, including cervical cancer (CC), endometrial cancer (EC), and ovarian cancer (OC), represent a significant global health burden for women.

1 Sep 2026

Could the type of fiber children eat matter for their developing gut microbiome?

A recent study found that different dietary fibers can shape the composition and activity of the gut microbiome during early childhood, with xyloglucan, arabinoxylan, and pectin increasing short-chain fatty acid production in laboratory fermentation experiments. Some fibers also supported gut barrier measures and altered inflammatory responses, while observational data linked higher pectin intake with greater microbial diversity in young children.

31 Aug 2026

Breastmilk from cannabis users showed differences, but cannabis may not be the whole story

A narrative review found that maternal cannabis use may be associated with differences in breastmilk fat, protein, lactose, and the immune factor secretory immunoglobulin A, but evidence comes primarily from only two human studies and remains limited and inconsistent. The authors stress that maternal diet, food security, socioeconomic circumstances, and other forms of adversity could confound these associations and should be incorporated into future research.

31 Aug 2026

A personalized elimination diet changed the gut microbiome in people with migraine

In a 12-week randomized, sham-controlled trial of 98 adults with migraine, eliminating IgG-positive foods altered gut microbial composition and produced a greater reduction in serum zonulin than a sham elimination diet. The microbial changes were associated with previously reported reductions in CGRP and IL-6 and improvements in migraine and sleep, although the authors emphasized that these mechanistic links remain exploratory.

31 Aug 2026

Researchers identify early molecular warning signs of inflammatory bowel disease

Researchers have uncovered early molecular warning signs of inflammatory bowel disease, revealing the condition can begin before symptoms appear and continue silently even when patients appear well.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 29 Aug 2026

FDA approves daraxonrasib for metastatic pancreatic cancer following landmark clinical trial led by Dana-Farber

The U.S. Food and Drug Administration (FDA) has approved daraxonrasib, an oral multi-selective RAS(ON) inhibitor, for adults with metastatic pancreatic adenocarcinoma who have received at least one prior systemic therapy or are not candidates for multiagent systemic therapy.

From Dana-Farber Cancer Institute, Inc. 29 Aug 2026

Probiotics for mental health? A new review finds promising signals and major gaps

This narrative review examines how psychobiotics may influence anxiety, depression, bipolar disorder, and schizophrenia through gut-brain pathways involving neurotransmitters, inflammation, immune regulation, gut barrier function, and stress signaling. Specific Lactobacillus and Bifidobacterium strains showed encouraging effects, but wide differences in strains, doses, populations, and study designs currently limit clinical translation.

28 Aug 2026

Scientists reviewed 20 edible and medicinal fungi for clues to better prebiotics

A review of 20 non-toxic edible and medicinal fungal species found that their polysaccharides can resist digestion, interact with gut microbes, and influence microbial metabolites linked to intestinal and metabolic health. The evidence suggests potential benefits for conditions including colitis, type 2 diabetes, and obesity, although most findings currently come from laboratory and animal studies.

27 Aug 2026

Gut microbiome atlas maps how bacteria establish themselves and shift in inflammatory bowel disease

Researchers created a microbiome-wide atlas mapping more than seven million colonization factor genes across 4,716 human gut microbial species, revealing three putative strategies linked to metabolism, stress resistance, and microbial communication. Applying the framework to inflammatory bowel disease showed that colonization-factor profiles can provide a compact, biologically interpretable view of disease-associated microbiome changes.

27 Aug 2026

FDA approves first RAS-targeted therapy for metastatic pancreatic cancer

27 Aug 2026

Maternal immune response to urinary tract infection may drive preterm birth risk

A new study published in Science Translational Medicine shows that the increased risk of preterm pregnancies associated with urinary tract infection (UTI), is linked to the body's immune response to the infection rather than to the bacteria themselves.

26 Aug 2026

Phytoene in tomatoes may help protect against fatty liver disease

New study suggests a lesser-known compound in tomatoes may help protect against fatty liver disease, which affects more than 1 in 3 American adults.

26 Aug 2026

Gut bacteria may send different biological signals in Parkinson’s disease

A new study from the University of Oulu suggests that gut bacteria may send different biological signals in Parkinson’s disease.

26 Aug 2026

Scientists found a distinct gut microbiome pattern in people with symptomatic diverticular disease

A multicenter Japanese study found that symptomatic uncomplicated diverticular disease (SUDD) was associated with reduced gut microbial diversity, increased abundance of the Ruminococcus gnavus group, and depletion of Coprococcus and other butyrate-producing bacteria. Predictive microbiome analysis also identified enrichment of pathways linked to exopolysaccharide biosynthesis and the cell cycle, although the observational design means these associations cannot establish causality.

25 Aug 2026