Gastrointestinal Health

This hub offers a comprehensive resource on gastrointestinal health, digestive diseases, and the human microbiome, drawing together authoritative articles on basic science, clinical management, and emerging research. The collection addresses the pathophysiology, diagnosis, and treatment of major gastrointestinal disorders, including irritable bowel syndrome, celiac disease, inflammatory bowel disease, and gastroesophageal reflux, while also exploring surgical, dietary, and pharmacological interventions. Special emphasis is given to the role of the gut microbiome in health and disease, including its influence on immunity, metabolism, neurological function, and response to therapy. Readers will also find up-to-date insights into microbiome-related interventions, such as fecal microbiota transplantation, as well as practical guidance for dietary management and prevention. This hub serves as a trusted reference for clinicians, researchers, and individuals seeking an evidence-based understanding of digestive and microbiome science.

Can you Treat a Food Allergy by Altering the Gut Microbiome?

There is a relationship between gut microbiome and allergy which may allow some children to outgrow their food allergy.

Gastritis Symptoms

Gastrointestinal Stromal Tumor (GIST) Signs and Symptoms

Irritable Bowel Syndrome (IBS) Research

Gastrointestinal Stromal Tumor (GIST) Treatment

Dermatitis Herpetiformis and Celiac Disease

Post-Infectious Irritable Bowel Syndrome

Gastrointestinal Stromal Tumor (GIST) Diagnosis

Gastric Bypass Benefits

Is There a Link Between Migraine and the Gut Microbiome?

Gastrointestinal Stromal Tumor Pathogenesis

Gastrointestinal Stromal Tumor (GIST) Causes

See more featured articles »

Treatment of Gastric Varices

FODMAPs and Irritable Bowel Syndrome (IBS)

Do Serotonin and Antidepressants Affect the Microbiome?

Human Microbiome

Gastrointestinal Bleeding Treatment

Gastric Bypass Criteria

Microbiome and Disease

Treatment and Prognosis for Intestinal Malrotation

Alzheimer's Disease and the Microbiome

Gastritis Causes

Gastric Varices

Short-Chain Fatty Acids (SCFAs)

What is Gastrointestinal Bleeding?

Gastroparesis Treatments

Diagnosis of Irritable Bowel Syndrome

Drug Metabolism and Microbiome

Gut Microbiota

What is Celiac Disease?

Treatment of Gastro-Esophageal Reflux Disease (GERD)

What is Vaginal Microbiome?

Gastrointestinal Disease and Skin Problems

What is Gastroschisis?

Gastroparesis Epidemiology

Genetics of Inflammatory Bowel Disease (IBD)

Fecal Microbiota Transplant Technique

What is Irritable Bowel Syndrome?

Sarin Classification of Gastric Varices

What is a Gastric Bypass?

Functional Gastrointestinal Disorders: Integrating Physiological and Psychological Approaches

Is Dermatitis Herpetiformis Caused by Herpes?

Malrotation of the Gastrointestinal Tract

Treatment of Irritable Bowel Syndrome

Irritable Bowel Syndrome (IBS) Prognosis

Antibiotics and the Microbiome

Gastroparesis Causes

Irritable Bowel Syndrome (IBS) Comorbidities

What is Gastroparesis?

Irritable Bowel Syndrome (IBS) and Infections

How to Recover Gut Health After Clostridium difficile Infection

Dysbiosis and Aging

Genetic Factors that Influence Bacterial Diversity in the Human Gut

Gastrointestinal Bleeding Symptoms

Celiac Disease Symptoms

High FODMAP Foods and Low FODMAP Food Alternatives

Gastroschisis Prognosis

Human Microbiome Project (HMP)

What is Gastroenterology?

Diabetic Gastroparesis

Microbiome-Host Cell Interactions

Celiac Disease Screening

Achievements of the Human Microbiome Project

Celiac Disease Treatment

Symptoms and Diagnosis of Intestinal Malrotation

Celiac Disease Diagnosis

The Microbiome and Aging

Crohn's Disease Cause

Mesentery: a new organ?

Irritable Bowel Syndrome (IBS) and Psychiatric Illness

Symptoms of Irritable Bowel Syndrome

Gastritis Treatments

Types of Gastrectomy

Disease Susceptibility and the Microbiome

Irritable Bowel Syndrome (IBS) and Diet

Does Wheat Cause Gut Inflammation?

Diagnosis of Gastro-Esophageal Reflux Disease (GERD)

Gastric Carcinoma

Risk Factors for Small Intestinal Bacterial Overgrowth

Causes of Bleeding in the Upper and Lower Gastrointestinal Tract

Gastric Bypass Types

What is Gluten?

Irritable Bowel Syndrome (IBS) and Stress Response

Gastroparesis Symptoms

Irritable Bowel Syndrome (IBS) and Exercise

Fecal Microbiota Transplant

Irritable Bowel Syndrome (IBS) Food Triggers

Does the Microbiome Interact with the Human Endocrine System?

Probiotics and IBS

Parkinson's Disease and the Gut Microbiome

Inflammatory Bowel Disease (IBD) in Pregnancy

Irritable Bowel Syndrome (IBS) Epidemiology

What is Gastroenteritis?

What does Sleeve Gastrectomy Involve?

Effects of a Gluten-Free Diet on the Gut Microbiota

Conjunctiva microbiota

Celiac Disease Pathogenesis

Fecal Microbiota Transplant Regulation

Gut-on-a-Chip to Model Coeliac Disease

Dysbiosis and the Microbiome

Causes of Gastro-Esophageal Reflux Disease (GERD)

Self-Help for Irritable Bowel Syndrome (IBS)

What is Gastritis?

Irritable Bowel Syndrome (IBS) Differential Diagnosis

What is Ulcerative Colitis?

Ulcerative Colitis Causes

Irritable Bowel Syndrome (IBS) Psychological Therapies

Symptoms of Gastro-Esophageal Reflux Disease (GERD)

ERCP (Endoscopic Retrograde Cholangiopancreatography) Overview

Skin Microbiota

Low FODMAP Diet

FODMAP Research

Gastritis Diagnosis

Gastroparesis Diagnosis

Gastroschisis Causes

Oral Microbiota

Fermented Foods and Gut Health

Gastric Bypass Complications

Gastroparesis and Diet

Irritable Bowel Syndrome (IBS) and Fibromyalgia

Gastric Varices - Signs and Symptoms

After Gastric Bypass Surgery

Causes of Irritable Bowel Syndrome

Mechanism of Irritable Bowel Syndrome (IBS)

Microbiome and Cancer

How Does the Diet Impact Microbiota?

Inflammatory Bowel Disease and Colorectal Cancer

Latest Gastrointestinal Health News and Research

Study reveals how ozone exerts multi-organ effects by disturbing the lung-liver connection

Ozone pollution is rising worldwide, frequently exceeding safety thresholds in urban centers and industrial regions. Its health risks are well-documented: breathing ozone can worsen asthma, damage airways, and increase the risk of cardiovascular and neurological disorders.

17 Sep 2025

Can changing food texture reduce how much we eat? Dutch study investigates

A new randomized controlled trial protocol from the Netherlands will test whether altering the texture, and thus the eating rate, of ultra-processed foods can reduce daily energy intake. The study will investigate how sensory properties, such as food hardness, affect metabolism, appetite, and microbiome composition.

16 Sep 2025

Personalized risk information does not increase colorectal cancer screening rates

A new Indiana University School of Medicine clinical trial - the largest of its kind to date - found that providing personalized colorectal cancer risk information to patients and their health care providers did not improve screening rates for the deadly ailment.

16 Sep 2025

Ketogenic diets may lower migraine frequency and medication use

This narrative review argues that the migraine brain is hypometabolic, with converging evidence of mitochondrial dysfunction, impaired glucose handling, neuroinflammation, microbiome shifts, and obesity-related pathways. It proposes ketogenic diets as a plausible preventive strategy that may reduce monthly migraine days and medication use, while emphasizing the need for larger, rigorous randomized trials and careful clinical oversight.

14 Sep 2025

New diagnostic code brings recognition and support for Gulf War Illness

Gulf War illness (GWI), the chronic, debilitating condition linked to military service in the 1990-1991 Gulf War, will receive a dedicated diagnostic code in the October 2025 release of the International Classification of Diseases (ICD-10-CM).

11 Sep 2025

New genetic test redefines diagnosis and management of hereditary pancreatitis

A new genetic test developed at Mayo Clinic is redefining how clinicians diagnose and manage hereditary pancreatitis.

11 Sep 2025

Genes play an active role in shaping the gut bacteria, study finds

New research from the University of Sydney's Charles Perkins Centre has found that genes play an active role in shaping the bacteria found in our gut, questioning the idea that gut health is influenced only by diet.

10 Sep 2025

Mediterranean-style diet benefits maternal health during pregnancy and breastfeeding

A Mediterranean-style diet, rich in fiber, vegetable proteins and healthy fats, benefits maternal health during pregnancy and breastfeeding.

10 Sep 2025

Long-read sequencing uncovers massive DNA elements shaping human oral microbiome

Researchers including those at the University of Tokyo have made a surprising discovery hiding in people's mouths: Inocles, giant DNA elements that had previously escaped detection.

10 Sep 2025

Specific microbial changes linked to poor growth in children

Malnutrition is responsible for more than half of all deaths in children under the age of five worldwide.

10 Sep 2025

Precision nutrition offers new pathways to slow biological aging

Diet doesn't just fuel the body, it sends molecular signals that can slow down or speed up biological aging, according to a new perspective in npj Aging (Nature Portfolio).

10 Sep 2025

Healthier diets and diverse oral microbiomes lower frailty risk

This study links diet and oral microbiome diversity to frailty risk, emphasizing their potential in strategies for healthier aging and improved health outcomes.

10 Sep 2025

Study uncovers new associations between gut microbiome and aging process

A new research paper was published in Volume 17, Issue 8 of Aging-US on August 1, 2025, titled "Causal relationships between gut microbiome and hundreds of age-related traits: evidence of a replicable effect on ApoM protein levels."

10 Sep 2025

Kids with fluctuating gut microbiome show poorer growth

Malnutrition is a leading cause of death in children under age 5, and nearly 150 million children globally under this age have stunted growth from lack of nutrition.

9 Sep 2025

Study uncovers three-way relationships between gut fungi, genetics and disease risk

A new genome-wide study uncovers evidence of the first three-way relationships between human genetic variation, variation in the fungal component of the human microbiome - known as the mycobiome - and risk of developing chronic disease.

9 Sep 2025

What diet pattern worsens inflammatory bowel disease?

Researchers compare the different effects of pro-inflammatory dietary patterns on inflammatory bowel disease severity.

9 Sep 2025

Why smartphone use on the toilet may increase hemorrhoid risk

Adults using smartphones on the toilet spent significantly more time seated and had 46% higher odds of hemorrhoids on colonoscopy. The cross-sectional study suggests prolonged sitting, not straining, may be the key driver of hemorrhoid risk.

8 Sep 2025

Core sugars in breast milk fuel gut and brain health beyond 12 months

Researchers reviewed 13 studies of human milk oligosaccharides (HMOs) through 24 months of breastfeeding, analyzing 4,786 samples. Six “core” HMOs remained dominant, with total concentrations plateauing after 12 months and evidence suggesting persistence into the second year.

8 Sep 2025

How breast milk changes from day to night and why timing matters

Breast milk's hormonal and microbial variations throughout the day may affect infant development, emphasizing the need for synchronized feeding practices.

8 Sep 2025

Frailty and microbial imbalance drive GI complications in bladder cancer surgery

Gastrointestinal (GI) complications, such as postoperative ileus (POI) and intra-abdominal infections (IAI), remain a major concern after radical cystectomy for bladder cancer.

8 Sep 2025