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New compounds reduce inflammation without weakening immune defense

Scripps Research scientists have developed a new class of drug compounds that reduce harmful inflammation while leaving the body's ability to fight infections intact-a long-sought goal in treating autoimmune diseases.

6 Apr 2026

Expanded Medicaid improved access to buprenorphine for opioid use disorder

Medicaid insurance expansions between 2017 and 2023 sharply increased access to medication treatment for opioid use disorder in a period when fatal overdoses continued to climb, according to Rutgers Health researchers.

6 Apr 2026

New strategy exploits specific genetic vulnerability in colorectal cancer patients

Researchers have identified a novel therapeutic approach for colorectal cancer by exploiting a specific genetic vulnerability found in a majority of patients.

6 Apr 2026

Scientists create large library of mitochondrial DNA mutant models

Some of your most important life partners are the mitochondria that power all your cells. You and these little cellular powerhouses are in a 1.5-billion-year-old evolutionary relationship-but mitochondria brought some baggage.

6 Apr 2026

New guidelines aim to improve concussion care for first responders

Management of sports-related concussions has come a long way in the past 25 years: Once considered a minor problem involving minimal time out of the game, a severe knock to the head is now assessed as a potential traumatic brain injury and, if confirmed, requires a structured recovery and an average wait of 13 days before play resumes.

6 Apr 2026

Study shows how blind people map surroundings using sound

Some blind people use returning echoes from their own mouth clicks to perceive external surroundings, or echolocation.

6 Apr 2026

Estonian study reveals varied stress responses during first pandemic year

Karel Kulbin, a well-being researcher at Tallinn University, focuses in his doctoral thesis on how perceived stress levels and depressive symptoms among Estonian residents changed during the first year of the pandemic and what role active leisure activities played in this.

6 Apr 2026

New target identified to overcome resistance in neuroendocrine tumors

Neuroendocrine cells are unique in their ability to act both as nerve cells and hormone-making cells.

6 Apr 2026

Prickly pear may pack a surprising punch against metabolic syndrome

This narrative review examines how Opuntia ficus-indica fruit, or prickly pear, may help target multiple features of metabolic syndrome through its fiber, betalains, polyphenols, carotenoids, and other bioactive compounds. The authors conclude that the fruit shows promising mechanistic and preclinical potential, but stronger human trials are still needed before firm clinical claims can be made.

6 Apr 2026

Study shows masculine depression is not just a male mental health pattern

Researchers found that depressed inpatients with high masculine depression scores had a substantially greater acute mental health burden across multiple symptom domains, even after accounting for overall depression severity. The paper also found this pattern was not specific to men, supporting “masculine depression” as a descriptive, sex-independent behavioral profile rather than a male-only condition.

6 Apr 2026

How gut microbes may shape heart attack damage and recovery

This review argues that gut microbes and the metabolites they produce, especially SCFAs and TMAO, may shape how the heart responds to myocardial infarction through epigenetic pathways such as DNA methylation, histone modification, and non-coding RNAs. It also outlines potential intervention routes, including diet, probiotics, postbiotics, and metabolite-targeted therapies, while noting that much of the evidence remains translational and not yet clinically definitive.

6 Apr 2026

AI helps researchers find antimicrobial peptides in Earth’s harshest habitats

Researchers built the Extreme Environment Microbiome Catalog from 78,213 genomes across global extreme habitats, revealing major taxonomic and biosynthetic novelty, including 32,715 representative species, nearly 4 billion non-redundant genes, and 163,693 biosynthetic gene clusters. They then used protein language models to identify 3,032 candidate non-toxic antimicrobial peptides, with 84 of 100 synthesized peptides showing antibacterial activity and low cytotoxicity in the 50 tested in mammalian cells.

6 Apr 2026

Flu vaccination may cut heart attack and stroke risk after infection

In Danish adults aged 40 years or older, laboratory-confirmed influenza was linked to a sharp short-term rise in first-time heart attack and stroke risk, especially in the first 7 days after infection. Prior same-season influenza vaccination was associated with about half the excess cardiovascular risk among infected individuals, suggesting possible protection even in breakthrough cases.

6 Apr 2026

Evolocumab trial could reshape how doctors treat high-risk cholesterol patients

A new ACC/AHA dyslipidemia guideline and editorial argue that guideline development is rigorous but can lag behind fast-moving science, using the VESALIUS-CV trial as a clear example. The trial showed that intensive LDL cholesterol lowering with evolocumab reduced cardiovascular events in high-risk patients without prior heart attack or stroke, with implications for future guideline updates.

6 Apr 2026

New method identifies key proteins that trigger harmful immune responses

Mayo Clinic researchers have developed a new method to identify which proteins are most likely to trigger an immune response - a discovery that could help improve transplant care, regenerative medicine and other areas where the immune system plays a critical role.

6 Apr 2026

Mayo Clinic researchers develop experimental nanotherapy to treat aggressive brain tumors

Mayo Clinic researchers developed an experimental nanotherapy that delivers two cancer drugs directly to brain tumors, according to a study published in Communications Medicine.

6 Apr 2026

Large-scale exposome research shows how multiple factors influence disease risk

For decades, scientists have been carefully unraveling the role of genes in disease by examining how small variations in a person's genetic code can shape lifelong risk of developing common conditions such as cancer, diabetes, or heart disease.

6 Apr 2026

JMIR Publications' new article showcases the transformative potential of precision oncology

JMIR Publications today announced the release of a timely new article in its News and Perspectives section, showcasing the transformative potential of precision oncology.

6 Apr 2026

Remote monitoring technology helps Brooklyn resident manage high blood pressure

When 57-year-old Brooklyn resident Timothy Rhonda visited Park Ridge Family Health Center at NYU Langone with dangerously high blood pressure, he worried he might once again end up in the hospital.

6 Apr 2026

Solitary screen time increases socioemotional problems for children with language difficulties

Early problems with language can have a lasting negative impact on social and emotional development. Building on this foundation, a new groundbreaking study from Florida Atlantic University and Aarhus University in Denmark tests the hypothesis that unsupervised, solitary screen time during early childhood increases the likelihood that language difficulties will lead to socioemotional difficulties.

6 Apr 2026