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Skin and internal organs sense cold through different molecular pathways

A research team led by Félix Viana, co-director of the Sensory Transduction and Nociception laboratory at the Institute for Neurosciences (IN), a joint research centre of the Spanish National Research Council (CSIC) and Miguel Hernández University of Elche (UMH), has demonstrated that the body uses different molecular mechanisms to detect cold in the skin and in internal organs.

19 Dec 2025

New research reveals a hidden source of cellular bioelectricity

Many biological processes are regulated by electricity-from nerve impulses to heartbeats to the movement of molecules in and out of cells.

19 Dec 2025

Hidden kinase state enables rapid and repeated protein phosphorylation

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its target, without needing to release and reattach to the target each time.

19 Dec 2025

Mitochondria shift toward the cell edge in response to glucose

Unlike our organs, cell organelles such as mitochondria are not fixed in place, but when, where, how, and why organelles move remain unclear.

19 Dec 2025

Genes influence the gut microbiome beyond the individual

The gut microbiome - made up of trillions of microbes in the digestive tract - is vital for digestion and overall health. Diet and medication shape these microbial ecosystems, but the contribution of genetics has been more difficult to ascertain.

19 Dec 2025

New open-source tool maps gene regulation networks in cancer

University of Navarra (Spain) researchers have developed RNACOREX, a new open-source software capable of identifying gene regulation networks with applications in cancer survival analysis.

19 Dec 2025

Simulations explore possible encounters between Neanderthals and modern humans

Researchers at the University of Cologne use simulations to investigate the likelihood of interactions between Neanderthals and anatomically modern humans on the Iberian Peninsula / publication in “PLOS One”.

19 Dec 2025

New insights into how a molecular gatekeeper controls early protein modification

For years, ETH researchers have been investigating a molecular complex that plays a key role in protein synthesis. They have now discovered that this complex also contributes a crucial function in ensuring that our DNA is properly processed and “packaged”.

19 Dec 2025

DNA twisting controls how cells respond to estrogen

Estrogens, the main female sex hormone, although they also perform some functions in men, are involved in a myriad of processes, which is why the body changes so much during menopause. This is because estrogens regulate hundreds of genes.

19 Dec 2025

Viral DNA elements help control early embryonic development

Transposable elements are stretches of DNA that can move around the genome. Many of these DNA sequences originate from long ago, when viruses inserted their genetic material into our ancestors' genomes during infection.

19 Dec 2025

Younger epigenetic age linked to increased depression in older women

A new research paper was published in Volume 17, Issue 11 of Aging-US on November 18, 2025, titled "Epigenetic age predicts depressive symptoms during the COVID-19 pandemic in the Canadian Longitudinal Study on Aging: importance of biological sex."

19 Dec 2025

Autophagy steers T cell fate during immune division

Researchers at the Max Delbrück Center have found that a cellular housekeeping mechanism called autophagy plays a major role in ensuring that T stem cells undergo normal cell division.

19 Dec 2025

Plastic waste transformed into building blocks for cancer drugs

A groundbreaking discovery led by the University of St Andrews has found a way to turn ordinary household plastic waste into the building block for anti-cancer drugs.

19 Dec 2025

CHITOSE and FUJIFILM Biosciences form strategic alliance to drive global innovation and biopharmaceutical manufacturing

Chitose Laboratory Corp., (CHITOSE), a leading company of the bioeconomy and provider of advanced cell line development services, and FUJIFILM Biosciences Inc., a global leader in the innovation and manufacture of cell culture solutions for the life science market, today announced a new strategic alliance that leverages the strengths of both companies in advancing biopharmaceutical production.

18 Dec 2025

Researchers provide a global catalog of human pluripotent stem cell lines for clinical use

To date, more than 100 clinical trials with human pluripotent stem cell (hPSC)-derived products have been initiated worldwide and an increasing number of potential hPSC-derived clinical products have entered early developmental pipelines.

18 Dec 2025

Phages use small RNA to hijack bacterial cells and boost replication

As antibiotic-resistant infections rise and are projected to cause up to 10 million deaths per year by 2050, scientists are looking to bacteriophages, viruses that infect bacteria, as an alternative.

18 Dec 2025

Junk' DNA may hold new clues to Alzheimer’s disease

When most of us think of DNA, we have a vague idea it's made up of genes that give us our physical features, our behavioral quirks, and keep our cells and organs running.

18 Dec 2025

Social living allows genetic effects to spread through the gut microbiome

Your "roommate's" genes could be influencing the bacteria living in your gut, and vice versa, according to a study of rats published today in Nature Communications.

18 Dec 2025

Flu wave’s hidden cost on people with cystic fibrosis

People with cystic fibrosis (CF) are uniquely vulnerable to the flu wave currently ripping through the UK, a clinical researcher from The University of Manchester has warned.

18 Dec 2025

Genetic differences can affect the effectiveness of antibody therapies

The genome differs from person to person in thousands of positions. In some cases, this means that proteins have a different building block in certain regions, rendering some antibody-based therapies ineffective, report researchers from the University of Basel, Switzerland.

17 Dec 2025