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Innovative approaches in polymer nanoparticle synthesis for RNA therapeutics

RNA therapy with polymer nanoparticles is considered a promising approach for the treatment of various illnesses.

15 Jul 2024

One-time prime editing targets common genetic cause of cystic fibrosis

Researchers optimized prime editing for the efficient correction of the cystic fibrosis transmembrane conductance regulator F508del mutation in human airway epithelial cells, achieving high correction efficiencies and functional restoration with minimal off-target effects.

15 Jul 2024

Predicting behavior from image features: Insights from cortical tuning

Researchers investigate whether the human occipital-temporal cortex (OTC) co-represents the semantic and affective content of visual stimuli to guide behavior.

15 Jul 2024

TurCaMPb: A novel tool for monitoring mitochondrial calcium dynamics

Mitochondria are crucial for maintaining calcium balance in cells, but their calcium dynamics are challenging to study due to pH changes in the mitochondrial matrix, and the lack of cyan-colored GECIs hinders the monitoring of calcium signals across different organelles and cell types.

14 Jul 2024

New 3D model sheds light on amyloid-beta's impact

Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have unveiled a pioneering study shedding light on the intricate mechanisms underlying Alzheimer's disease (AD). The study, titled "Effects of amyloid-β-mimicking peptide hydrogel matrix on neuronal progenitor cell phenotype," represents a significant leap forward in understanding the interplay between amyloid-like structures and neuronal cells.

13 Jul 2024

Mice experiment mimicking foster care raises ethical concerns

Tom Green County District Court Judge Barbara L. Walther ruled Thursday, July 11, 2024, that Angelo State University must release public records relating to an experiment conducted on dozens of mice that resulted in the animals' unnecessary suffering and death, reportedly to study the impact of the foster care system on human children.

13 Jul 2024

Gene editing silences mutant microRNA, restores hearing in adult mice

Researchers have used gene editing to restore hearing in adult mice with a type of inherited hearing loss. They showed that shutting down a damaged copy of a gene called a microRNA (miRNA) enabled the animals to regain hearing. The approach by a research team supported by the National Institutes of Health (NIH), reported in Science Translational Medicine, may eventually lead to potential treatments for inherited hearing loss in people.

13 Jul 2024

Novel DNA aptamers of melanopsin developed to regulate circadian rhythm

DNA aptamers of melanopsin that regulate the clock hands of biological rhythms were developed by the Toyohashi University of Technology and the National Institute of Advanced Industrial Science and Technology (AIST) group.

12 Jul 2024

Optical metabolic imaging reveals how Toxoplasma infection changes host cell metabolism

Toxoplasma gondii is a parasite responsible for toxoplasmosis, a lifelong chronic infection prevalent in about 30% of the human population.

12 Jul 2024

Immune cell inflammation may be responsible for some severe symptoms in lysosomal storage diseases

Researchers at The Hospital for Sick Children (SickKids) have found that inflammation in an immune cell may be responsible in part for some severe symptoms in a group of rare genetic conditions called lysosomal storage diseases (LSDs).

12 Jul 2024

Accelerate Your Research: Dispen3D Harnesses the Power of 3D Models

Dispen3D is setting new standards in single-cell biology, enabling researchers to conduct high-precision experiments that drive advancements in drug discovery, personalized medicine, and regenerative therapies.

From SEED Biosciences 12 Jul 2024

Enzymatic RNA synthesis paves the way for sustainable therapeutics

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and amyloidosis.

12 Jul 2024

Cellular immunotherapy offers hope for solid tumors

Early findings from a small clinical trial provide evidence that a new cellular immunotherapy approach may be effective in treating metastatic solid tumors. In the trial, researchers from the National Institutes of Health (NIH) genetically engineered normal white blood cells, known as lymphocytes, from each patient to produce receptors that recognize and attack their specific cancer cells.

12 Jul 2024

Scientists map molecules within human brain for first time

Scientists investigating Alzheimer's disease have determined the structure of molecules within a human brain for the very first time.

12 Jul 2024

How lipoproteins shape your metabolic health

Study provides a comprehensive review of the lipoprotein pathway and its impact on healthy metabolism, highlighting the roles of HDL, LDL, and other lipoproteins in cardiovascular health and disease.

11 Jul 2024

deCODE genetics study highlights potential drug targets for autoimmune thyroid disease

Scientists at deCODE genetics, a subsidiary of Amgen, have published a study in Nature Communications, comparing over 110 thousand patients with autoimmune thyroid disease (AITD) from Iceland, Finland, UK and USA with 1,1 million controls.

11 Jul 2024

New study reveals the genetic cause of Parkinson's disease

According to Science Alert, neuroscientists from Johns Hopkins University have recently discovered a new treatment for Parkinson's disease using an FDA-approved cancer drug.

11 Jul 2024

Study reveals how DDM1 protein suppresses 'jumping genes' in plants

International joint research led by Akihisa Osakabe and Yoshimasa Takizawa of the University of Tokyo has clarified the molecular mechanisms in thale cresses (Arabidopsis thaliana) by which the DDM1 (Decreased in DNA Methylation 1) protein prevents the transcription of "jumping genes."

11 Jul 2024

Prime editing offers promising path to permanent treatment for cystic fibrosis

Cystic fibrosis is one of the most common genetic disorders, causing thick mucus build-up in the lungs and other parts of the body, breathing problems, and infection.

11 Jul 2024