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Protein cleavage mechanism sheds light on severe childhood ciliopathies

New research by Sumeda Nandadasa, PhD, reveals how a key protein associated with Meckel-Gruber syndrome, nephronophthisis, Joubert syndrome and other ciliopathies is cut in half to perform two separate functions, both of which are fundamental to the healthy development of children.

27 Jun 2025

New study reveals how diverse brain cells unite to guide decisions

Every decision begins invisibly. Long before someone acts, the brain is already hard at work gathering evidence, weighing options, and gradually committing to a choice.

27 Jun 2025

LMU researchers uncover mechanism for metabolism without cell membranes

LMU researchers have demonstrated a possible mechanism for metabolic processes without cell membranes in water-filled pores.

27 Jun 2025

Deciphering the structure of human protease SENP5 unlocks new therapeutic paths

A research led by the IBB-UAB has managed to decypher the structure of the human protease SENP5, implicated in neurodegenerative disorders, cardiovascular diseases and the development of cancer.

27 Jun 2025

New study reveals how nymphaeol A interacts with cell membranes

A new study by Professor José Villalaín, Chair of Biochemistry and Molecular Biology at the Miguel Hernández University of Elche (UMH), provides a detailed description of how nymphaeol A - a compound found in propolis - behaves when interacting with cell membranes.

27 Jun 2025

New center in Copenhagen to pioneer the future of protein design

Proteins are the workhorses of biology. They perform virtually every important function in living organisms. They store, copy and protect our DNA, digest food to give us energy, and harness this energy to make our cells and muscles work.

27 Jun 2025

Soil bacterium offers clues for new bioactive compounds

A recent study by an interdisciplinary research team shows how a soil bacterium can become a source of inspiration in the search of new active substances.

27 Jun 2025

Largest Indian genome study reveals 50,000 years of genetic history

With around 5,000 different ethno-linguistic and religious groups, India is one of the most culturally and genetically diverse countries in the world.

26 Jun 2025

Harnessing saliva for precision medicine and early disease diagnosis

A research team led by the University of the Basque Country (Euskal Herriko Unibertsitatea, EHU) has identified hundreds of molecular markers in saliva that could reveal the risk of a person developing major diseases such as cancer, cardiovascular diseases, diabetes and neurodegenerative diseases.

26 Jun 2025

Yeast cell division found to begin inside the nucleus

Researchers at the Francis Crick Institute have shown that the 'pacemaker' controlling yeast cell division lies inside the nucleus rather than outside it, as previously thought.

26 Jun 2025

Ribonucleases revealed as key players in Mendelian disorders

A new review brings to light the pivotal role of ribonucleases (RNases) in shaping the molecular foundation of Mendelian disorders.

26 Jun 2025

Unknown organelle discovery could open the door to new treatments for inherited diseases

The discovery of an unknown organelle inside our cells could open the door to new treatments for devastating inherited diseases.

26 Jun 2025

Parse Biosciences GigaLab to support Mount Sinai researchers in generating one of the largest Alzheimer's and Parkinson's single cell datasets

Parse Biosciences today announced their commitment to support researchers from the Icahn School of Medicine at Mount Sinai in generating one of the largest single cell datasets focused on understanding alternative splicing events in the cells of Alzheimer's and Parkinson's patients.

From Parse Biosciences 26 Jun 2025

Fusion genes found to be pivotal players in cancer development

Fusion genes, arising from abnormal chromosomal rearrangements, are gaining recognition as pivotal players in cancer development. These genetic alterations result in the creation of hybrid genes with altered functions, often driving tumor progression.

25 Jun 2025

TET1 identified as key regulator in cancer and chronic disease

Recent findings shed new light on the critical role of TET1, a pivotal player in epigenetic regulation, in the development and progression of various clinical diseases.

25 Jun 2025

LINE-1 elements found essential for early embryonic development

A new review from Genes and Diseases sheds light on the pivotal role of LINE-1 elements in preimplantation development and totipotency, revealing their essential contributions to early mammalian embryogenesis.

25 Jun 2025

Enhanced Genomics and The ALBORADA Drug Discovery Institute partner to accelerate Alzheimer's drug discovery

Enhanced Genomics ('Enhanced'), the biotechnology company pioneering 3D multi-omics to rapidly identify high-confidence, genetically validated drug targets for common diseases, today announced a strategic partnership with The ALBORADA Drug Discovery Institute at the University of Cambridge.

25 Jun 2025

Scientists use base editing to repair mitochondrial DNA mutations

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor.

25 Jun 2025

How a novel reaction in E. coli helps recycle plastic into paracetamol

Researchers have demonstrated that E. coli can perform a biocompatible Lossen rearrangement, enabling phosphate-catalysed conversion of synthetic substrates into valuable compounds. This approach allows engineered bacteria to upcycle PET plastic waste into paracetamol, highlighting a novel intersection of chemistry and biotechnology.

24 Jun 2025

Scientists create ALS on a chip to uncover disease clues

Using stem cells from patients with ALS (amyotrophic lateral sclerosis), Cedars-Sinai has created a lifelike model of the mysterious and fatal disease that could help identify a cause of the illness as well as effective treatments.

24 Jun 2025