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Acetate and gut bacteria work together to reduce obesity in mice

Researchers led by Hiroshi Ohno at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered a new way to reduce obesity.

19 May 2025

Study uncovers common trigger across gene mutations that cause ALS

Using the gene scissors CRISPR and stem cells, researchers at Stockholm University and the UK Dementia Research Institute (UK DRI) at King's College London have managed to identify a common denominator for different gene mutations that all cause the neurological disease ALS.

19 May 2025

Newly discovered Cat1 protein halts viral infections by depleting cellular fuel

Every living creature on Earth needs to protect itself from things that would do it harm. Bacteria are no different. And despite their relative simplicity, they deploy remarkably savvy defensive strategies against viral invaders.

18 May 2025

Genomic study of non-Hispanic Black veterans with prostate cancer yields key insights for precision medicine

In the largest clinical genomic profiling study of non-Hispanic Black men with metastatic prostate cancer to date, researchers from Moffitt Cancer Center, University of Pennsylvania, University of California Los Angeles and the Veterans Affairs (VA) National Precision Oncology Program found key differences in tumor biology between non-Hispanic Black and non-Hispanic white veterans, but similar survival outcomes when both groups had equal access to care.

16 May 2025

Research identifies seven genes that drive hematopoietic stem cell fate

Stem cells can produce any other cell type, it is just a matter of telling them in the right way. From a biological perspective, this means activating the proper genetic programme by pressing the right keys, this is, the right genes, at the right moment.

16 May 2025

Floral diversity supports honeybee survival through winter

Especially in temperate climates, winter poses a major challenge for honeybee colonies. To ensure their survival, the animals must maintain the right temperature in the hive and raise the next generation of workers.

16 May 2025

Study reveals subtle effects of recessive mutations on health and reproduction

As a group, carriers of recessive disorders are slightly less healthy and have a reduced chance of having offspring.

16 May 2025

Optimer licensing agreements and repeat custom

Aptamer Group plc, the leading developer of next-generation synthetic binders delivering innovation to the life science industry, has announced two new development contracts for Optimer binders and the agreement of licensing heads of terms with a global provider of specialty enzymes for developed enzyme-modulating Optimers.

From Aptamer Group 16 May 2025

Aptamer announces new data at ASGCT

Aptamer Group plc, the leading developer of next-generation synthetic binders delivering innovation to the life science industry, presented new data on its Optimer therapeutic delivery vehicle for liver fibrosis at the American Society of Gene and Cell Therapy (ASGCT) Annual Meeting in New Orleans, LA (13-17 May 2025).

From Aptamer Group 16 May 2025

New gene editor evoCAST enables precise insertion of complete genes

Ask scientists what gene editing tool is most needed to advance gene therapy, and they'd probably describe a system that's now close to realization in the labs of Samuel Sternberg at Columbia University Vagelos College of Physicians and Surgeons and David Liu at the Broad Institute of MIT and Harvard.

15 May 2025

New genetic database sheds light on Brazil’s ancestry and disease risks

Since the human genome was first sequenced in 2003, the world's scientific community has been racing to decipher this "book" written in an alphabet of four letters.

15 May 2025

Researchers identify key cells behind peanut allergy prevention

A decade ago, a clinical trial in the U.K. famously showed that children who were exposed to peanuts in the early months of life had reduced risk of developing a peanut allergy compared with children who avoided peanuts.

15 May 2025

Customized CRISPR gene editing therapy successfully treats infant with rare disease

In a historic medical breakthrough, a child diagnosed with a rare genetic disorder has been successfully treated with a customized CRISPR gene editing therapy by a team at Children's Hospital of Philadelphia (CHOP) and Penn Medicine.

15 May 2025

Allen Institute introduces CellScapes to map cellular cooperation

The Allen Institute today announced the launch of CellScapes, a bold new research initiative aimed at revolutionizing how scientists understand and predict the behavior of human cells as they work together to build tissues and organs.

15 May 2025

New stem cell model replicates human amniotic sac development

Researchers at the Francis Crick Institute have developed a new stem cell model of the mature human amniotic sac, which replicates development of the tissues supporting the embryo from two to four weeks after fertilization.

15 May 2025

Two genetic variants linked to breast cancer discovered in black South African women

Genetic factors contribute to some 30% of breast cancer cases in SA, necessitating investment in genomic research in African contexts.

15 May 2025

SLIRP protein identified as key regulator of immune responses

Even after the COVID-19 pandemic, various new infectious diseases continue to emerge, posing ongoing viral threats that demand robust and sustained immune defenses.

15 May 2025

Eating only wild foods reshapes your gut microbiome in just weeks, study shows

A new study shows that an eight-week wild-food-only diet in a modern adult leads to dramatic, partially lasting changes in the gut microbiome’s composition and function. While no “ancestral” microbes reappeared, the shift increased fiber-degrading species and reduced dairy-associated bacteria, highlighting the powerful role of diet.

14 May 2025

New technology maps molecules within single cells to uncover disease mechanisms

Tissues consist of a heterogenous mixture of different cell types, complicating our understanding of their biological functions and studies of disease.

14 May 2025

New candidate compounds show promise for Alzheimer's and pain treatment

A study published in the Journal of Medicinal Chemistry presents a new family of candidate compounds for the treatment of Alzheimer's disease and pain, which have shown promising effects in animal models.

14 May 2025