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Researchers boost effectiveness of malaria drug by tweaking its symmetry

A new generation of malaria drugs failed clinical trials, in part because they were hard to swallow. UCSF chemists remodeled their structures to make them more soluble, while maintaining their effectiveness against drug-resistant parasites.

11 Aug 2025

Researchers develop precise tool to identify omega positions in lipids

Omega-3 fatty acids are known to be an essential part of a healthy diet. As humans cannot produce them, they have to be consumed in sufficient amounts. However, omega-6, -7, -9, and -10 fatty acids also play important roles in the metabolism of fats.

11 Aug 2025

AI model can design optimal drug candidates without any prior molecular data

Traditional drug development methods involve identifying a target protein (e.g., a cancer cell receptor) that causes disease, and then searching through countless molecular candidates (potential drugs) that could bind to that protein and block its function.

11 Aug 2025

New imaging technique reveals how antibodies reshape cancer cell receptors

A new study shows how the single-molecule organization of receptors in a cellular context determines the function of antibodies, opening up new pathways for the development of cancer immunotherapies.

11 Aug 2025

Tokyo researchers reveal key role of Fen1 in resisting antiviral and anticancer drug effects

Researchers from Tokyo Metropolitan University have discovered a new pathway by which cells counteract the action of alovudine, an important antiviral and anticancer drug.

10 Aug 2025

New insights into how MYOD controls muscle repair and regeneration

For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells.

8 Aug 2025

All-atom models reveal novel protein misfolding mechanism

New computer simulations that model every atom of a protein as it folds into its final three-dimensional form support the existence of a recently identified type of protein misfolding.

8 Aug 2025

Decoding macrophage immune responses with gene editing and machine learning

Fighting off pathogens is a tour de force that must happen with speed and precision. A team of researchers at CeMM and MedUni Vienna led by Christoph Bock and Matthias Farlik has investigated how macrophages-immune cells that are the body's first responders-master this challenge.

8 Aug 2025

Uncovering the nuclear PIPn-p53 signalosome in cancer cell migration

In this review, the authors present recent findings that uncover a previously unappreciated nuclear signaling hub: the PIPn-p53 signalosome.

8 Aug 2025

Revolutionizing therapeutic protein design with synthetic biology

In medicine and biotechnology, the ability to evolve proteins with new or improved functions is crucial, but current methods are often slow and laborious.

8 Aug 2025

RNA sequencing reveals molecular drivers for better regenerative therapies

Researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have documented their use of a new RNA sequencing technology to uncover molecular drivers of cellular differentiation that could lead to better regenerative therapies.

8 Aug 2025

CRISPR screening uncovers microproteins involved in fat storage

The obesity rate has more than doubled in the last 30 years, affecting more than one billion people worldwide.

7 Aug 2025

Researchers uncover dozens of traits driven by maternal versus paternal genes

Researchers developed a high-accuracy method to infer whether genetic variants come from the mother or father without needing parental genomes, analysing 286,666 UK Biobank participants. They uncovered over 30 parent-of-origin effects on traits from growth and metabolism to diabetes, many showing opposite effects depending on parental source.

7 Aug 2025