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Innovative cryo-microscopy offers precise views of rapid cell activity

Optical microscopy is a key technique for understanding dynamic biological processes in cells, but observing these high-speed cellular dynamics accurately, at high spatial resolution, has long been a formidable task.

25 Aug 2025

Next-gen sequencing reveals the regulatory potential of the non-coding genome

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark achievements of the Human Genome Project (HGP), scientists have increasingly focused on deciphering the non-coding regions of the human genome, which comprise approximately 98% of the genetic material.

23 Aug 2025

Balancing speed and selectivity is key for designing effective targeted covalent inhibitors

One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs).

22 Aug 2025

New microfluidics-based workflow enables high-resolution lipid imaging in C. elegans

Understanding how fat molecules are distributed and function in living organisms is key to uncovering mechanisms of aging, disease, and metabolism.

22 Aug 2025

Epstein-Barr virus protein enhances cancer gene activity in HPV-positive cervical cells

A new research paper was published in Volume 16 of Genes & Cancer on August 6, 2025, titled "Epstein-Barr virus nuclear antigen 1 upregulates Derlin1 and PSMD10 expression in HeLa cells."

22 Aug 2025

New method enables comprehensive analysis of metabolites in biological samples

Researchers from the McCullagh Group in Oxford University's Department of Chemistry have published an innovative method in Nature Protocols today (22 August) that provides comprehensive analysis of metabolites found in cells, tissues and biofluids.

22 Aug 2025

AI and advanced microscopy reveal tangled DNA structures with nanometer precision

At school, it's often presented as a tidy double helix but scientists are revealing the varied and intricate shapes of DNA molecules.

22 Aug 2025

Computational framework deciphers cellular organization

One of the most fundamental processes in all of biology is the spontaneous organization of cells into clusters that divide and eventually turn into shapes – be they organs, wings, or limbs.

22 Aug 2025

University of Vienna team develops method to measure molecular charges

An international research team led by the University of Vienna has succeeded in developing a new method to directly measure partial charges in molecules. The results, now published in Nature, provide new insights into molecular interactions and offer potential applications in drug development and materials science.

22 Aug 2025

Study reveals genome rewiring mechanism driving mantle cell lymphoma

Translocations are chromosomal "cut and paste" errors that drive many lymphomas, a type of blood cancer and the sixth most common form of cancer overall.

21 Aug 2025

Research shows how lysosomes respond to stress

New research, published today in the journal Science, shows how lysosomes - organelles that act like cells' waste disposal system - respond to stress by becoming abnormally bloated, a process called lysosomal vacuolation that is associated with numerous diseases.

21 Aug 2025

Single-cell proteomic analysis uncovers hidden layers of blood cell formation

In the past decade there has been significant interest in studying the expression of our genetic code down to the level of single cells, to identify the functions and activities of any cell through the course of health or disease.

21 Aug 2025

Yale researchers uncover new RNA editing tools for safer genetic surgery

The ability to correct disease-causing genetic mistakes using genome editors holds great promise in medicine, but it is not without risk.

21 Aug 2025

Physical forces play key role in shaping developing organs

A new study looks at the physical forces that help shape developing organs. Scientists in the past believed that the fast-acting biochemistry of genes and proteins is responsible for directing this choreography.

21 Aug 2025

Using light to control tissue folding in developing embryos

The complex 3D shapes of brains, lungs, eyes, hands, and other vital bodily structures emerge from the way in which flat 2D sheets of cells fold during embryonic development.

21 Aug 2025

Computational approach provides insight into neural progenitor cells and their role in brain disorders

For much of the 20th century it was thought that the adult brain was incapable of regeneration. This view has since shifted dramatically and neurogenesis – the birth of new neurons – is now a widely accepted phenomenon in the adult brain, offering promising avenues for treating many neurological conditions.

21 Aug 2025

New genome-wide CRISPR screening tool boosts natural killer cells to fight cancer

Natural killer (NK) cells became markedly better at killing cancer cells after scientists removed key gene targets identified through a new genome-wide CRISPR screening tool, according to new research from The University of Texas MD Anderson Cancer Center.

21 Aug 2025

Nanodroplet array revolutionizes search for new drugs

Until now, the early phase of drug discovery for the development of new therapeutics has been both cost- and time-intensive.

21 Aug 2025

AI predicts designer drug structures for improved detection

How does one identify something no one has a test for? Designer drugs replicate the effects of known, illicit drugs but evade law enforcement. The chemical structure variations that help these compounds avoid detection also make them unpredictable in the body - a quality that poses serious health consequences.

21 Aug 2025

UCSF researchers uncover how breast cancer steals energy from fat cells

UCSF scientists caught cancer cells in the act of breaking into fat cells and releasing their fat. The energy heist seems to be critical for the growth of deadly breast cancer.

20 Aug 2025