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Blocking nutrient scavenging weakens pancreatic tumor defenses

Cancer cells and tumors do not exist in a vacuum. Far from the isolation and self-sufficiency of the fictional Wakanda, tumors develop in and alter the nearby milieu of immune cells, connective tissue, blood vessels and a sea of proteins and carbohydrates that provide structure and other supportive functions.

24 Jul 2025

IRF-5 identified as key to preventing immune cell exhaustion

In fighting chronic infections or certain cancers, CD8+ T cells-the immune system's frontline soldiers-eventually become exhausted. They lose effectiveness and respond less efficiently to threats.

24 Jul 2025

High-resolution whole-cortex imaging reveals neurovascular dynamics in awake mice

Neurovascular coupling (NVC) is the dynamic regulation of cerebral blood flow in response to neural activity. Specifically, when neurons become active, nearby blood vessels dilate to increase blood supply, thereby meeting the heightened energy demands associated with neural activity.

24 Jul 2025

New redox-sensitive pathway reveals how cells activate AMPK in response to metabolic stress

AMP-activated protein kinase (AMPK) plays a central role in maintaining energy balance in cells, especially under energy stress.

24 Jul 2025

AI-driven microscopy predicts and tracks protein aggregation in real time

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington's, Alzheimer's and Parkinson's.

24 Jul 2025

Scientists discover neuron-like communication system in the gut

In a key advance for regenerative medicine and gut health, scientists from Duke-NUS Medical School and Nanyang Technological University, Singapore (NTU Singapore) have uncovered a precise and unexpected communication system in the gut.

24 Jul 2025

Reactivating silent genes offers hope for Rett syndrome treatment

Researchers led by UC Davis Health scientist Sanchita Bhatnagar have developed a promising gene therapy that could treat Rett syndrome.

23 Jul 2025

New method genetically blocks mosquitoes from transmitting malaria

Mosquitoes kill more people each year than any other animal. In 2023, the blood-sucking insects infected a reported 263 million people with malaria, leading to nearly 600,000 deaths, 80% of which were children.

23 Jul 2025

New collaborative effort harnesses AI to drive ALS drug discovery in Louisiana

Answer ALS is proud to announce the launch of a groundbreaking collaborative initiative aimed at accelerating AI-powered drug discovery for ALS and other neurodegenerative diseases.

23 Jul 2025

New insights reveal how FtsZ and ZapA cooperate during bacterial cell division

Bacterial cell division, a process wherein a single cell divides to form two identical daughter cells, represents one of the most essential biological processes.

22 Jul 2025

New imaging technique reveals how cells organize glucose processing

In a scientific first, researchers from Vanderbilt University and the University of California, San Diego, have generated a high-resolution metabolic "map" of how cells orchestrate glucose processing, revealing a hidden world where organelles and molecular complexes collaborate when responding to a rush of nutrients.

22 Jul 2025

Study shows how ribose may have become the sugar of choice for RNA development

In living organisms today, complex molecules like RNA and DNA are constructed with the help of enzymes.

22 Jul 2025

PhoreMost demonstrates new approach to rationalize molecular glue drug discovery

PhoreMost Ltd., a next-generation targeted protein degradation (TPD) company progressing a pipeline of degrader therapeutics within oncology and inflammation, today announced the publication of a study demonstrating the capabilities of its high-throughput GlueSEEKER platform to accelerate the design and development of novel molecular glue degraders.

22 Jul 2025

Toti-N-Seq breakthrough enables universal and scalable single-cell profiling

The rapid advancement of single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) has opened unprecedented windows into cellular diversity, yet existing methods for multiplexing samples struggle with scalability and accuracy.

22 Jul 2025

UC Riverside scientists develop tool to preserve mitochondrial DNA

When environmental stress harms DNA, it can set off a cascade of failures linked to heart conditions, neurodegeneration, and chronic inflammation.

21 Jul 2025

Immune cells navigate tissues with coordinated cytoskeletal forces

Immune responses rely on the efficient movement of immune cells within the complex and geometrically unpredictable three-dimensional tissues that make up our bodies.

21 Jul 2025

Muscle-derived vesicles heal damaged cells and reverse disease in new study

Researchers discovered that mitochondria-rich extracellular vesicles (Ti-mitoEVs) from skeletal muscle can deliver healthy mitochondria to damaged cells, restoring energy and promoting tissue repair in mice. The approach reversed acute muscle injury and chronic kidney disease, offering a promising new regenerative therapy.

21 Jul 2025