Conjunctiva microbiota

NewsGuard 100/100 Score

The eye has three structures that work together to protect it, namely, the , eyelids and lacrimal apparatus.

The conjunctiva is a transparent mucous membrane that covers the front of the eye. While a person is awake, the eye is constantly exposed to microbes. The skin is known to be home to many of the microbes found in the eye microbiota such as streptococci and coryneforms. However, not all skin microbes are also found in the eye, suggesting that only certain ones are selected for and present within the conjunctiva microbiota.

Credit: Vic29/

The microbiota that reside on the conjunctiva is mainly made up of the following:

  • Diptheroids
  • Hemophilus-like Gram-negative bacilli
  • Non-hemolytic streptococci
  • Staphylococci
  • Neisseria

Other microbes found on the conjunctiva that are part of the normal microbiota include:

  • Staphylococcus aureus
  • Peptococcus sp
  • Clostridium sp
  • Peptostreptococcus sp
  • Cephalosporium sp
  • Fusarium sp
  • Propionibacterium sp

The conjunctiva is constantly exposed to the external environment and therefore vulnerable to contamination with microbes. The extent of invasion by fungi, Gram-negative rods and pathogenic bacteria is controlled by the immune system and the lacrimal apparatus. The lacrimal apparatus of the eye removes the majority of these microbes, meaning the microbiota that remains is of a comparatively low density and only made up of a limited amount of species.

Humans tend to blink about 12 times per minute, on average, which protects the eye from microbial contamination by providing a “tear film” over the eye’s surface. Tears contain lysozymes, beta-lysine, immunoglobulin G (IgG) and lactoferrin, and bacteria are killed by the synergistic actions of these substances.

The antimicrobial properties of tears are reflected in the fact that patients with Bell’s palsy, for example, who have lost the ability to blink and remove microorganisms from the cornea, often develop bacterial conjunctivitis. Tears also act mechanically, removing the majority of invading microbes from the conjunctiva through the lacrimal ducts.

The conjunctiva is also lined with lymphocytes, dendritic cells, neutrophils and plasma cells that rapidly respond to infection by generating antibodies, which provides a highly effective barrier to microbial invasion. It is very difficult for microbes to penetrate tissue deeper within the eye, unless this defence system has been disrupted in some way.

If trauma occurs and this barrier is penetrated, the deeper ocular tissue becomes susceptible to blood-borne infections such as tuberculosis and herpes, which causes inflammation of the eye’s middle layer or choroid.

How the eye microbiota might confer protection against pathogens remains unclear, but it is known that resident streptococci and coryneforms, for example, produce toxins called bacteriocins that inhibit the growth of similar bacterial strains, therefore making the environment unsuitable for potentially pathogenic microbes.

Further Reading

Last Updated: Feb 26, 2019

Sally Robertson

Written by

Sally Robertson

Sally first developed an interest in medical communications when she took on the role of Journal Development Editor for BioMed Central (BMC), after having graduated with a degree in biomedical science from Greenwich University.


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Robertson, Sally. (2019, February 26). Conjunctiva microbiota. News-Medical. Retrieved on May 25, 2024 from

  • MLA

    Robertson, Sally. "Conjunctiva microbiota". News-Medical. 25 May 2024. <>.

  • Chicago

    Robertson, Sally. "Conjunctiva microbiota". News-Medical. (accessed May 25, 2024).

  • Harvard

    Robertson, Sally. 2019. Conjunctiva microbiota. News-Medical, viewed 25 May 2024,


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Vaping poses unexpected risks to eye health, study finds