Type 1 Diabetes

Type 1 diabetes, formerly called juvenile diabetes or insulin-dependent diabetes, is usually first diagnosed in children, teenagers, or young adults. In this form of diabetes, the beta cells of the pancreas no longer make insulin because the body’s immune system has attacked and destroyed them. Treatment for type 1 diabetes includes taking insulin shots or using an insulin pump, making wise food choices, exercising regularly, controlling blood pressure and cholesterol, and taking aspirin daily—for some.

What is Type 1 Diabetes?

Type 1 diabetes mellitus describes a condition where the body cannot produce insulin which leads to a very high level of blood sugar and associated complications. The condition, which usually develops in childhood or adolescence, affects millions of people worldwide.

Diabetes Mellitus Type 1 Pathophysiology

Type 1 Diabetes Research

Type 1 Diabetes Cure

Diabetes Mellitus Type 1 Inheritance

Type 1 Diabetes Treatment

Type 1 Diabetes Prevention

Does the 'Stomach Flu' Vaccine Prevent Type I Diabetes?

Latest Type 1 Diabetes News and Research

Using a lab-designed protein to regulate blood glucose levels

Researchers at the Indiana University School of Medicine have discovered a new way to regulate blood glucose levels using a lab-designed protein, possibly opening the door to a new treatment avenue for people with Type 1 diabetes.

9 Oct 2025

Diabetic teens with poor glycemic control more likely to develop neuropathy in adulthood

Poor blood sugar control in adolescence increases the risk of painful future complications for people with type 1 diabetes, research co-led by University of Michigan suggests.

9 Oct 2025

Discovery of vascular-associated fibroblastic cells opens new path for diabetes treatment

Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks the cells that produce insulin-a critical hormone that regulates blood sugar in the body.

8 Oct 2025

New tool enables and enhances protein investigations

A new tool greatly improves scientists' ability to identify and study proteins that regulate gene activity in cells, according to research led by Weill Cornell Medicine investigators. The technology should enable and enhance investigations in both fundamental biology and disease research.

3 Oct 2025

How maternal microbes shape babies’ gut health and disease risk

Early microbial exposures from maternal microbes, milk components, and the environment shape infant gut development and long-term disease risk. The review highlights mechanisms, preventive levers, and research gaps in supporting healthy microbiome inheritance across generations.

29 Sep 2025

Scientists outline how future therapies could change type 1 diabetes care

Researchers writing in The Lancet review breakthroughs in type 1 diabetes treatment, from immunotherapies that delay onset to stem-cell β-cell replacement and automated insulin delivery. They stress that equitable access, validated surrogate endpoints, and scalable technologies are crucial for lasting impact.

24 Sep 2025

Scientists use blood chemistry to predict disease years before it strikes

Researchers built the largest plasma metabolome-phenome atlas using 274,241 UK Biobank participants, linking over 73,000 metabolite-trait and 52,000 metabolite-disease associations. The study shows metabolic risk scores can predict diseases years before diagnosis, with strong accuracy for diabetes and kidney complications.

22 Sep 2025

New study warns of millions of undiagnosed and missing people with type 1 diabetes

The global type 1 diabetes (T1D) burden continues to increase rapidly driven by rising cases, ageing populations, improved diagnosis and falling death rates, according to the results of a new modeling study being presented at this year's Annual Meeting of The European Association for the Study of Diabetes (EASD), Vienna (15-19 Sept).

19 Sep 2025

Oral drug baricitinib shows promise in slowing early type 1 diabetes progression

In 2023, the groundbreaking Australian BANDIT (Baricitinib in New Onset Type 1 Diabetes) trial [1] reported that a daily pill of baricitinib, commonly prescribed for rheumatoid arthritis and alopecia, could safely preserve the body's own insulin production and slow the progression of type 1 diabetes (T1D) in people recently diagnosed with the condition.

19 Sep 2025

New findings support low-dose ATG to delay progression of type 1 diabetes

New research presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) and published simultaneously in The Lancet shows that a much lower dose than previously thought of the old immunomodulatory drug anti-thymocyte globulin (ATG) is safe and effective in preventing progression of type 1 diabetes (T1D) in young people.

19 Sep 2025

Verapamil shows potential for preserving beta-cell function in type 1 diabetes

New research (the Ver-A-T1D trial) presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) (Vienna, 15-19 September) shows that slow-release (SR) verapamil (360mg daily) could have a potential effect on beta-cell function in adults with newly diagnosed type 1 diabetes.

18 Sep 2025

Hyperemesis gravidarum associated with increased neuropsychiatric disorders in pregnancy

The largest study on pregnant women with excessive nausea and vomiting (hyperemesis gravidarum) has identified increased risks of numerous neuropsychiatric and mental health outcomes.

18 Sep 2025

New EASD guideline combines clinical standards with lived experience

The guideline was developed in line with internationally recognized standards, including the GRADE methodology and the RIGHT reporting statement, and reflects the EASD's newly established Standard Operating Procedures for guideline development.

17 Sep 2025

GLP-1 drugs found to protect against diabetic retinopathy

GLP-1 receptor agonist drugs protect against diabetic retinopathy, a common complication of diabetes that can lead to sight loss, suggests new research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) and published in the journal Pharmaceutics.

17 Sep 2025

Weill Cornell Medicine receives $3.4 million NIH grant to study type 1 diabetes development

Weill Cornell Medicine has received a four-year, $3.4 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health, for a study of the details and dynamics of the autoimmune process that causes type 1 diabetes.

11 Sep 2025

First FDA-approved islet transplant at UI Health ends insulin dependence

Doctors at UI Health performed the first islet transplant with Lantidra, the only therapy approved by the U.S. Food and Drug Administration to treat brittle type 1 diabetes.

4 Sep 2025

Wayne State project advances efforts toward automated diabetes care

Despite advances in insulin therapy and automated delivery systems, people with Type 1 diabetes (T1D) still face a daily struggle: manually dosing insulin before meals.

28 Aug 2025

Antibiotics in pregnancy and infancy do not raise autoimmune disease risk in children

A nationwide Korean cohort study found that antibiotic use during pregnancy or early infancy did not increase overall risk of childhood autoimmune diseases. Subgroup signals for Crohn’s disease and autoimmune thyroiditis warrant cautious follow-up.

25 Aug 2025

Investigation raises concerns over tooth stem cell banking claims

Parents are spending thousands of pounds to bank stem cells from their children's milk teeth – but the recipient companies' claims about their future medical value are unproven and potentially misleading, reveals an investigation by The BMJ, published today.

21 Aug 2025