Cell Cycle News and Research

RSS

Finding may open new horizons for understanding the initiation of chemically induced cancers

A team from the chemistry and biology departments of New York University, in collaboration with Memorial Sloan Kettering Cancer Center (MSKCC), has uncovered a conformational switch - a change in shape in a carcinogen-damaged DNA site - in tumor suppressor genes altered by a known cancer-causing chemical found in cigarette smoke.

9 Mar 2005

Scientists have identified a key network that prevents damage by oxygen radicals

Reactive oxygen species (ROS), or 'oxygen radicals', have been identified as major contributors to signs of premature aging, increased cancer prevalence linked to inflammation-associated syndromes and a variety of human diseases.

6 Mar 2005

Cells can regenerate without becoming "younger"

It has long been thought that cells that regenerate tissue do so by regressing to a developmentally younger state. Now two University of Washington researchers have demonstrated that cells can regenerate without becoming "younger."

1 Mar 2005

Potential new therapies for cancer and bleeding disorders

Lexicon Genetics announced today that it has advanced two of its drug discovery programs into preclinical development in preparation for investigational new drug (IND) applications.

10 Jan 2005

How to uncover the secrets of disease-relevant proteins

Cancer researchers have developed a guide for piecing together the jigsaw puzzle of genome research - to elucidate cellular mechanisms that lead to diseases such as cancer is a big challenge of biomedicine.

23 Dec 2004

Blocking gene's activity may control deadly skin cancer without harming normal cells

Researchers at Dana-Farber Cancer Institute and Children's Hospital Boston have discovered that malignant melanoma, the potentially lethal skin cancer, can't grow without a steady supply of a protein that normal cells can do without.

20 Dec 2004

Bcl-6 oncogene - genetic target for lymphoma treatment

Results from a pre-clinical study show that the gene designated Bcl-6 is an oncogene -- that is, one with the potential to cause a normal cell to become cancerous -- but that certain peptide inhibitors can in effect inactivate it, according to a study to be presented today during the 46th Annual Meeting of the American Society of Hematology (ASH).

5 Dec 2004

Common antibacterial and antifungal ingredient used in tooth paste may protect against skin cancer

According to new studies, sanguinarine was shown to enhance production of proteins that induce cell death, or apoptosis, in cells damaged by ultraviolet-B (UVB) radiation.

21 Oct 2004

Studies reveal complex molecular choreography with implications for human health and disease

As interactions of cellular proteins increasingly take center stage in basic biomedical research, studies are revealing a complex molecular choreography with implications for human health and disease.

10 Oct 2004

Replication timing assays may allow much earlier cancer detection

Scientists have discovered a DNA sequence that is involved in controlling the timing of DNA replication. Because alterations in DNA replication timing are associated with cancer, this discovery may lead to improved methods for cancer detection.

26 Sep 2004

Cancers, including colon, prostate, and leukemia, continue to grow unchecked

Many cancers, including colon, prostate, and leukemia, continue to grow unchecked because they do not respond to a signal to die and stop proliferating from Transforming Growth Factor-beta (TGF-b).

8 Sep 2004

Researchers have identified multiple changes in the gene-expression patterns of cells involved with tumor progression in liver cancer patients

Virginia Commonwealth University researchers have identified multiple changes in the gene-expression patterns of cells involved with tumor progression in liver cancer patients and in those with cirrhosis, which may help scientists predict a person’s risk of developing primary liver cancer.

25 Aug 2004

New information about how HIV evades eradication from the body

Researchers at the National Cancer Institute, have discovered new information about how human immunodeficiency virus (HIV), the virus that causes acquired immune deficiency (AIDS), possibly evades eradication from the body.

23 Aug 2004

Authors redefine aging as any change in an organism over time

Voyager Pharmaceutical have announced the publication of a paper co-authored by its chief scientist, Richard Bowen, M.D., and Craig Atwood, Ph.D., research director of the University of Wisconsin Memory Research Program and the Wisconsin Alzheimer's Institute.

18 Aug 2004

Discovery of new ways to manipulate AIDS virus

16 Aug 2004

Possible role for BK virus in development of prostate cancer

Now, new research by scientists at the University of Michigan Medical School suggests the intriguing possibility that this common virus also may play a role in prostate cancer – the second-leading cause of deaths from cancer in American men.

9 Aug 2004

8.5 million Euros to address a fundamental question on mitosis: How is cell division regulated?

Scientists at the European Molecular Biology Laboratory (EMBL) join forces with top scientists from eleven research institutes in Austria, Germany, Italy, France and the United Kingdom for “MitoCheck” – the largest integrated research project on cell cycle control within the European Commission’s 6th Framework Programme (FP6).

15 Jul 2004

A drug derived from an ocean-growing sponge helps prevent the growth of cancer cells

A drug derived from an ocean-growing sponge teams up to enhance the performance of the yew tree derivative Taxol® (paclitaxel) in preventing the growth of cancer cells, according to research published in the July 15 issue of the journal Cancer Research.