Genetic Engineering News and Research

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Using a harmless amoeba to protect children from dangerous infections

Innovative efforts at the University of Virginia School of Medicine to use a harmless amoeba to protect children from dangerous infections has won critical financial support from The Hartwell Foundation.

10 Jun 2022

Creating CAR T cells without an immune brake

T cells are usually very good at eliminating diseased cells. But they seem to fail when it comes to tumor cells.

10 Jun 2022

Research reveals why many cancers are vulnerable to FDA-approved IDH1 inhibitors

A drug used to target IDH1 mutations in select cancers also appears to inhibit the wild-type form of the enzyme, under certain conditions.

9 Jun 2022

Novel approach to drug repurposing incorporates two-stage prediction and machine learning

A new study presents a novel approach to drug repurposing that incorporates two-stage prediction and machine learning.

7 Jun 2022

Color-changing mouse model aids in better visualization of internal physiology

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have developed a process to change the color of a mouse's tissue in imaging to better visualize its internal physiology.

6 Jun 2022

Molecular 'connector' may underlie gender differences in cocaine’s effects, mice study shows

Scientists have long known that cocaine works by latching on to molecular connectors on the surface of brain cells, allowing dopamine, a chemical that promotes feelings of pleasure and reward, to accumulate in the space between brain cells.

3 Jun 2022

Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse

Genetically engineered immune cells successfully target the specific cancer cells that may be responsible for relapse of acute myeloid leukemia (AML), a type of blood cancer, and proved effective in animal models of the disease, according to a preclinical study by investigators at Weill Cornell Medicine.

2 Jun 2022

Inhibiting immune response-related enzyme holds promise in preventing or treating severe COVID-19

Blocking an immune response-related enzyme holds promise in preventing or treating severe COVID-19 symptoms by reducing inflammation, tissue injury and blood clots in the lungs, new research in mice suggests.

1 Jun 2022

Genetically modified herpes virus can be used in the fight against cancer

Viruses can make animals and humans sick - or healthy: Researchers at the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB have succeeded in genetically modifying the herpes simplex virus type 1, which triggers painful cold sores, in such a way that it can be used in the fight against cancer in the future.

1 Jun 2022

Novel mechanism to turn on cancer-killing T cells identified

Over the past decade, researchers have made great strides in the development and administration of cancer immunotherapies, which use the body's own immune system to treat disease.

25 May 2022

Study brings precision medicine closer to reality for diffuse large B cell lymphoma

DNA mutations are essential to the rapid development of an array of antibody-producing immune cells called B cells that collectively can recognize a vast number of specific targets.

25 May 2022

Antibiotic rifampicin attenuates C9orf72-linked dementia in genetically modified mice

What did Stephen Hawking and Mao Zedong have in common? They both suffered from Amyotrophic Lateral Sclerosis (ALS), a cure for which remains elusive. Scientists from Osaka Metropolitan University took an important step toward prevention of ALS and another brain disorder called Frontotemporal dementia (FTD) with their research on the effects of the antibiotic rifampicin on genetically modified mice.

23 May 2022

Study demonstrates how the transcription factor C/EBPβ can positively influence fat storage

The chronic nutritional and metabolic disease of obesity is characterized by an excessive increase in body fat and its accumulation in tissues.

20 May 2022

Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

In a recent study posted to the bioRxiv* pre-print server, researchers from Belgium evaluated the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral drugs in a severe combined immunodeficient (SCID) mouse model.

18 May 2022

SARS-CoV-2 infection could increase the risk of brain degeneration seen in Parkinson's disease

Brain fog, headaches, insomnia are some of the neurological symptoms doctors have observed in COVID-19 patients.

18 May 2022

Study identifies cancer biomarkers based on a type of genetic modification

Biomarkers are often used during the management of cancer to guide treatment decisions and predict patient outcomes. However, it is often difficult to identify appropriate biomarkers that can be consistently reproduced and are easily analyzed with limited patient specimens.

18 May 2022

First patient dosed in Phase 1 clinical trial evaluating the safety of CF33-hNIS against solid tumors

Imugene Limited, a clinical stage immuno-oncology company, and City of Hope, one of the largest cancer research and treatment organizations in the United States, today announced that the first patient was dosed in a Phase 1 clinical trial evaluating the safety of novel cancer-killing virus CF33-hNIS VAXINIA when used in people with advanced solid tumors.

18 May 2022

Sonic hedgehog plays key role in the repair strategy of large bone injuries

A USC Stem Cell study in NPJ Regenerative Medicine presents intriguing evidence that large bone injuries might trigger a repair strategy in adults that recapitulates elements of skeletal formation in utero. Key to this repair strategy is a gene with a fittingly heroic name: Sonic hedgehog.

17 May 2022

Exercise increases levels of brain-derived neurotrophic factor which bolsters dopamine release

Exercise increases levels of a chemical involved in brain cell growth, which bolsters the release of the "feel good" hormone dopamine, a new study shows. Dopamine is known to play a key role in movement, motivation, and learning.

16 May 2022

Researchers use bacteriophages to treat antibiotic-resistant mycobacterial lung infection

For the first time, researchers have successfully used bacteriophages – viruses that kill bacteria – to treat an antibiotic-resistant mycobacterial lung infection, clearing the way for a young National Jewish Health patient with cystic fibrosis to receive a life-saving lung transplant.

13 May 2022

Genetic Engineering News and Research

Using a harmless amoeba to protect children from dangerous infections

Creating CAR T cells without an immune brake

Research reveals why many cancers are vulnerable to FDA-approved IDH1 inhibitors

Novel approach to drug repurposing incorporates two-stage prediction and machine learning

Color-changing mouse model aids in better visualization of internal physiology

Molecular 'connector' may underlie gender differences in cocaine’s effects, mice study shows

Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse

Inhibiting immune response-related enzyme holds promise in preventing or treating severe COVID-19

Genetically modified herpes virus can be used in the fight against cancer

Novel mechanism to turn on cancer-killing T cells identified

Study brings precision medicine closer to reality for diffuse large B cell lymphoma

Antibiotic rifampicin attenuates C9orf72-linked dementia in genetically modified mice

Study demonstrates how the transcription factor C/EBPβ can positively influence fat storage

Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

SARS-CoV-2 infection could increase the risk of brain degeneration seen in Parkinson's disease

Study identifies cancer biomarkers based on a type of genetic modification

First patient dosed in Phase 1 clinical trial evaluating the safety of CF33-hNIS against solid tumors

Sonic hedgehog plays key role in the repair strategy of large bone injuries

Exercise increases levels of brain-derived neurotrophic factor which bolsters dopamine release

Researchers use bacteriophages to treat antibiotic-resistant mycobacterial lung infection

Biochemistry eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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