Messenger RNA (mRNA) News and Research

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Loss of Merlin protein leads to abnormal growth of tumours

A study led by researchers from Plymouth University Peninsula Schools of Medicine and Dentistry has for the first time revealed how the loss of a particular tumour suppressing protein leads to the abnormal growth of tumours of the brain and nervous system.

17 May 2013

Better understanding of cells' development has implications in study of inflammatory diseases

Labs around the world, and a core group at Penn, have been studying recently described populations of immune cells called innate lymphoid cells. Some researchers liken them to foot soldiers that protect boundary tissues such as the skin, the lining of the lung, and the lining of the gut from microbial onslaught. They also have shown they play a role in inflammatory disease, when the body's immune system is too active.

15 May 2013

Mayo Clinic researchers identify 27 genes that respond differently to rubella vaccine

Using advanced genetic sequencing technology and analysis, Mayo Clinic vaccine researchers have identified 27 genes that respond in very different ways to the standard rubella vaccine, making the vaccine less effective for a portion of the population.

2 May 2013

Wistar researchers find surprising role for RNA-editing protein in gene silencing

RNA, once considered a bit player in the grand scheme by which genes encode protein, is increasingly seen to have a major role in human genetics.

2 May 2013

Analysis identifies 37 RNA molecules that might predict survival in breast cancer patients

A Big Data analysis that integrates three large sets of genomic data available through The Cancer Genome Atlas has identified 37 RNA molecules that might predict survival in patients with the most common form of breast cancer.

30 Apr 2013

Evidence shows progerin induced by ultraviolet light is responsible for premature skin aging

A study conducted by researchers at Boston University School of Medicine (BUSM) provides new evidence that longwave ultraviolet light (UVA) induces a protein that could result in premature skin aging.

26 Apr 2013

Advaita selected to participate in Michigan I-Corps program starting May 2013

Advaita, a Plymouth, MI biotechnology startup company spun out from Wayne State University, is one of 25 companies selected to participate in the new Michigan I-Corps program starting May 2013.

24 Apr 2013

Animal models of Huntington's disease allow better insights into disease's genetics

Scientific progress in Huntington's disease (HD) relies upon the availability of appropriate animal models that enable insights into the disease's genetics and/or pathophysiology.

23 Apr 2013

Research findings provide new hope for people suffering from dry eye disease

Natural lubricants play an important role in health, including a well-known effect to help prevent osteoarthritis in knee and ankle joints. However, much is still unknown about their role and function in other areas of the body.

19 Apr 2013

Junk DNA plays important role in brain development

Specific DNA once dismissed as junk plays an important role in brain development and might be involved in several devastating neurological diseases, UC San Francisco scientists have found.

16 Apr 2013

Antipsychotics seemed to normalize gene expression pattern in people with bipolar disorder: Study

Every day, millions of people with bipolar disorder take medicines that help keep them from swinging into manic or depressed moods.

12 Apr 2013

Study shows hsa-miR-146a overexpressed in most metastatic tumors

In order to kill, bladder cancer must metastasize, most commonly to the lung - what are the differences between bladder cancers that do and do not make this deadly transition? Research presented by the Director of the University of Colorado Cancer Center at the AACR Annual Meeting 2013 shows that one big difference is a little molecule known as hsa-miR-146a.

11 Apr 2013

Researchers discover novel protein that governs metastasis and chemoresistance in pediatric bone cancer

Human osteosarcoma samples are hard to come by, making the disease difficult to study. However, K9 bone cancer is genetically indistinguishable from the human form of the disease, and over 10,000 canine patients develop the disease every year.

10 Apr 2013

Exosome profiling of mRNAs and miRNAs in serum samples presented at AACR meeting

Exosome Diagnostics, a leading developer of biofluid-based molecular diagnostics for use in personalized medicine, today announced that the company is presenting a late-breaking abstract at the AACR Annual Meeting 2013, in Washington D.C.

9 Apr 2013

Clinical trial signals new era in treatment of neurodegererative disorders

The initial clinical trial of a novel approach to treating amyotrophic lateral sclerosis - blocking production of a mutant protein that causes an inherited form of the progressive neurodegererative disease - may be a first step towards a new era in the treatment of such disorders.

4 Apr 2013

CureVac begins CV9104 Phase 2b clinical trial in patients with castration-resistant prostate cancer

CureVac GmbH, a clinical stage biopharmaceutical company that has pioneered the development of a new class of therapies and vaccines based on messenger RNA, today announced that it has initiated a double-blind, randomized Phase 2b clinical trial of its RNActive cancer vaccine, CV9104, for the treatment of patients with castration-resistant prostate cancer.

28 Mar 2013

Researchers study how nerve cells repair themselves after injury

One molecule makes nerve cells grow longer. Another one makes them grow branches. These new experimental manipulations have taken researchers a step closer to understanding how nerve cells are repaired at their farthest reaches after injury.

25 Mar 2013

Two genes associated with rare autism-related disorders linked to general forms of autism: Study

A new study finds that two genes individually associated with rare autism-related disorders are also jointly linked to more general forms of autism. The finding suggests a new genetic pathway to investigate in general autism research.

22 Mar 2013

Columbia University Medical Center, NewYork-Presbyterian Hospital present research works at AAN meeting

The following research from Columbia University Medical Center and NewYork-Presbyterian Hospital is being presented at the 65th annual meeting of the American Academy of Neurology, March 16-23, 2013, in San Diego.

18 Mar 2013

New molecular sensor technique for cancer therapy detects lactate levels in individual cells

Cancer cells break down sugars and produce the metabolic acid lactate at a much higher rate than normal cells. This phenomenon provides a telltale sign that cancer is present, via diagnostics such as PET scans, and possibly offers an avenue for novel cancer therapies.

16 Mar 2013