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Scientists identify signaling pathway in liver cells linked to fibrosis

A healthy liver filters all the blood in your body, breaks down toxins and digests fats. It produces collagen to repair damaged cells when the liver is injured.

25 Apr 2024

CASGEVY gene therapy eliminates vaso-occlusive crises in sickle cell patients

In a landmark study, an international consortium led by researchers at Children's Hospital of Philadelphia (CHOP) published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs).

24 Apr 2024

NYU Langone surgeons perform first combined mechanical heart pump and gene-edited pig kidney transplant surgery

Surgeons at NYU Langone Health performed the first combined mechanical heart pump and gene-edited pig kidney transplant surgery.

24 Apr 2024

Natural obesity fighters: How coffee, tea, and cocoa combat weight gain

A review in Current Research in Food Science explores how bioactive compounds in coffee, tea, and cocoa combat obesity by inhibiting white adipogenesis and promoting brown adipogenesis and lipolysis.

22 Apr 2024

Top pharmaceutical company evaluates Optimer for precision liver medicine

Optimer delivery vehicle has been shipped to a pharma partner for external evaluation.

From Aptamer Group 22 Apr 2024

New urine-based test improves identification of high-grade prostate cancer

Researchers at the University of Michigan Rogel Cancer Center have developed a new urine-based test that addresses a major problem in prostate cancer: how to separate the slow-growing form of the disease unlikely to cause harm from more aggressive cancer that needs immediate treatment.

18 Apr 2024

The path to a better tuberculosis vaccine runs through Montana

A team of Montana researchers is playing a key role in the development of a more effective vaccine against tuberculosis, an infectious disease that has killed more people than any other.

18 Apr 2024

To stop fentanyl deaths in Philadelphia, knocking on doors and handing out overdose kits

On a narrow street lined with row houses and an auto body shop in the Kensington neighborhood of North Philadelphia, Marsella Elie climbs a home's front steps and knocks hard on the door.

17 Apr 2024

Common HIV drugs linked to reduced Alzheimer's disease risk

Alzheimer's disease (AD) currently afflicts nearly seven million people in the U.S. With this number expected to grow to nearly 13 million by 2050, the lack of meaningful therapies represents a major unmet medical need.

16 Apr 2024

The Lancet Breast Cancer Commission: Tackling inequalities, hidden costs, and empowering patients

Breast cancer is now the world's most common cancer; at the end of 2020, 7.8 million women were alive having been diagnosed in the previous five years.

16 Apr 2024

LabVantage celebrates customer success with record number of software deployments in FY 2024

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From LabVantage Solutions 15 Apr 2024

Restoring insulin sensitivity without TZD side effects

Thiazolidinediones (TZDs) are a class of drug that can be used to treat type 2 diabetes by reversing insulin resistance, one of the main hallmarks of the disease.

13 Apr 2024

Cystic fibrosis drug found to be safe and effective in newborns

A Cystic Fibrosis drug targeting the basic defect that causes the condition has been shown to be safe and effective in newborns aged four weeks and above, new research involving RCSI University of Medicine and Health Sciences and Children's Health Ireland has found.

12 Apr 2024

Cannabis compound d-limonene reduces anxiety-inducing effects of THC

A Johns Hopkins Medicine-led research team has added to evidence that a chemical found naturally in cannabis (also known as marijuana) can -; in the right amounts -; lessen the anxiety-inducing effects of tetrahydrocannabinol (THC), the primary psychoactive sister chemical found in cannabis.

12 Apr 2024

Three early-phase clinical studies show promising initial data for patients with lymphoma, gastric cancers

Three early-phase clinical studies presented by researchers from The University of Texas MD Anderson Cancer Center at the American Association for Cancer Research (AACR) Annual Meeting 2024 show promising initial data for patients with lymphoma, gastric or gastroesophageal junction cancers, and specific molecularly selected tumors.

10 Apr 2024

Home-administered nasal spray could be safely used to treat recurrent rapid heart rhythms

A clinical trial led by Weill Cornell Medicine investigators showed that a nasal spray that patients administer at home, without a physician, successfully and safely treated recurrent episodes of a condition that causes rapid abnormal heart rhythms.

9 Apr 2024

Ninerafaxstat shows good tolerability and safety in nonobstructive HCM patients

The investigational drug ninerafaxstat showed a good tolerability and safety profile, along with evidence of improvements in symptoms and exercise capacity among people with nonobstructive hypertrophic cardiomyopathy (HCM), according to results of a 12-week phase 2 trial presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Study shows reduced bleeding risk with ticagrelor monotherapy after percutaneous coronary intervention

People who have had a heart attack or who are at risk for a heart attack and who stopped taking aspirin alongside the P2Y12 inhibitor ticagrelor one month after undergoing percutaneous coronary intervention (PCI) saw a significantly reduced risk of clinically meaningful bleeding with no increased risk of clotting-related adverse events at 12 months compared with patients who continued taking aspirin and ticagrelor for a full year, in a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Investigational drug plozasiran shows promise in reducing severe hypertriglyceridemia

In patients with severely elevated triglyceride levels at risk for developing acute pancreatitis, the investigational drug plozasiran reduced triglyceride levels by an average of 74% after 24 weeks of use without causing any significant safety concerns, according to research presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Ten doctors on FDA panel reviewing Abbott heart device had financial ties with company

When the FDA recently convened a committee of advisers to assess a cardiac device made by Abbott, the agency didn't disclose that most of them had received payments from the company or conducted research it had funded — information readily available in a federal database.

8 Apr 2024

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Pharmaceuticals News and Research

Scientists identify signaling pathway in liver cells linked to fibrosis

CASGEVY gene therapy eliminates vaso-occlusive crises in sickle cell patients

NYU Langone surgeons perform first combined mechanical heart pump and gene-edited pig kidney transplant surgery

Natural obesity fighters: How coffee, tea, and cocoa combat weight gain

Top pharmaceutical company evaluates Optimer for precision liver medicine

New urine-based test improves identification of high-grade prostate cancer

The path to a better tuberculosis vaccine runs through Montana

To stop fentanyl deaths in Philadelphia, knocking on doors and handing out overdose kits

Common HIV drugs linked to reduced Alzheimer's disease risk

The Lancet Breast Cancer Commission: Tackling inequalities, hidden costs, and empowering patients

LabVantage celebrates customer success with record number of software deployments in FY 2024

Restoring insulin sensitivity without TZD side effects

Cystic fibrosis drug found to be safe and effective in newborns

Cannabis compound d-limonene reduces anxiety-inducing effects of THC

Three early-phase clinical studies show promising initial data for patients with lymphoma, gastric cancers

Home-administered nasal spray could be safely used to treat recurrent rapid heart rhythms

Ninerafaxstat shows good tolerability and safety in nonobstructive HCM patients

Study shows reduced bleeding risk with ticagrelor monotherapy after percutaneous coronary intervention

Investigational drug plozasiran shows promise in reducing severe hypertriglyceridemia

Ten doctors on FDA panel reviewing Abbott heart device had financial ties with company

Oxygen Measurement eBook - Easily Understand Dissolved Oxygen Measurement eBook

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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