Ubiquitin News and Research

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Ubiquitin is a small regulatory protein that has been found in almost all cells (''ubiquitously'') with nuclei (eukaryotes). It directs proteins to recycling and other functions.

Computer program could help dementia patients manage their disease

Researchers at Weill Cornell Medical College have developed a computer program that has tracked the manner in which different forms of dementia spread within a human brain. They say their mathematic model can be used to predict where and approximately when an individual patient's brain will suffer from the spread, neuron to neuron, of "prion-like" toxic proteins -- a process they say underlies all forms of dementia.

22 Mar 2012

Researchers discover a connection of peroxisomal protein import and receptor export

The group of Prof. Dr. Ralf Erdmann at the Ruhr-Universit-t Bochum discovered a connection of peroxisomal protein import and receptor export. In the Journal of Biological Chemistry, they disclosed that enzymes only get imported into certain cell organelles (peroxisomes) upon coupling of their import to the recycling of their transport protein.

13 Feb 2012

SENP1 prevents STAT5 from becoming trapped in nucleus

When SUMO grips STAT5, a protein that activates genes, it blocks the healthy embryonic development of immune B cells and T cells unless its nemesis breaks the hold, a research team led by scientists at The University of Texas MD Anderson Cancer Center reports today in Molecular Cell.

30 Jan 2012

Scientists reveal structure of cellular protein degradation machinery

Defective proteins that are not disposed of by the body can cause diseases such as Alzheimer's or Parkinson's. Scientists at the Max Planck Institute (MPI) of Biochemistry recently succeeded in revealing the structure of the cellular protein degradation machinery (26S proteasome) by combining different methods of structural biology.

24 Jan 2012

Actavis, Scil Proteins sign Reteplase supply agreement

Scil Proteins, a private biotech company specialized in the research, development and production of recombinant proteins, announced today that it has signed a supply agreement with Actavis, one of the world's leading generic pharmaceutical companies, for the future manufacturing of Reteplase.

17 Jan 2012

Elevated ISG15 pathway may provide therapeutic targets for breast cancer

Interferon-stimulated gene 15 (ISG15), a ubiquitin like protein, is highly elevated in a variety of cancers including breast cancer. How the elevated ISG15 pathway contributes to tumorigenic phenotypes remains unclear and is the subject of a study published in the January 2012 issue of Experimental Biology and Medicine.

12 Jan 2012

Alteration in ISG15 pathway triggers breast cancer metastasis

Research led by Shyamal Desai, PhD, Assistant Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, has discovered a key change in the body's defense system that increases the potential for breast cancer to spread to other parts of the body.

4 Jan 2012

Six UNC faculty members named AAAC fellow

Six University of North Carolina at Chapel Hill faculty members have been named fellows of the American Association for the Advancement of Science.

16 Dec 2011

Israeli Nobel Laureate receives AvH's Humboldt Research Award

The Israeli Nobel Laureate Aaron Ciechanover has been named one of the recipients of the Humboldt Research Award of the Alexander von Humboldt Foundation.

8 Dec 2011

Scientists discover clues to the pancreatic cysts' possible origins

Scientists at Johns Hopkins have surveyed the DNA in four common types of pancreatic cysts, and have determined that each type bears a distinct pattern of gene mutations. Pancreatic cysts are present in about two percent of U.S. adults, and can, in some cases, require surgical removal and microscopic analysis to determine their type and likelihood of turning cancerous.

8 Dec 2011

Study reveals underlying molecular mechanism contributing to development of lymphomagenesis

Researchers from the NYU Cancer Institute, an NCI-designated cancer center at NYU Langone Medical Center, have discovered a new potential therapeutic target for Diffuse Large B-Cell Lymphoma (DLBCL), the most aggressive and common type of lymphoma in adults.

29 Nov 2011

Novel proteomics based method detects inhibition of intracellular deubiquitylating enzymes

Researchers at the University of Oxford and Progenra, Inc. are pleased to announce the publication of a research article entitled "Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes" that details a novel proteomics based method to detect inhibition of intracellular deubiquitylating enzymes (DUBs).

28 Nov 2011

American high school students earn top honors for liver disease and brain injury research

The shortlist of contenders for the highest science honor awarded to American high school students narrowed tonight as the winners of the Siemens Competition in Math, Science & Technology Region 3 Finals were announced.

21 Nov 2011

Advaxis licenses ISG15 tumor antigen from University of Pennsylvania

Advaxis, Inc., a leader in developing the next generation of immunotherapies for cancer and infectious diseases, has exclusively licensed the use of antigen ISG15 in Advaxis' Lm-LLO based immunotherapies from the University of Pennsylvania.

16 Nov 2011

Scil Proteins completes manufacturing agreement with Lundbeck

Scil Proteins, a private biotech company specialized in the research, development and production of recombinant proteins, announced today the successful completion of a manufacturing agreement for Lundbeck, an international pharmaceutical company specializing in central nervous system disorders.

15 Nov 2011

Lower glycemic index diet may delay onset of AMD-like lesions

Feeding older mice a lower glycemic index (GI) diet consisting of slowly-digested carbohydrates delays the onset of age-related, sight-threatening retinal lesions, according to a new study from the Laboratory for Nutrition and Vision Research at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University.

14 Nov 2011

Protein p97/VCP aids DNA repair like a corkscrew

Human genetic material is constantly at risk of injury from the environment. Possible causes of damage include metabolic processes, chemical substances or ionizing radiation, such as X-radiation.

9 Nov 2011

Researchers discover key mechanism responsible for degrading ubiquitinated protein aggregates

Researchers at the RIKEN Brain Science Institute (BSI) have discovered a key mechanism responsible for selectively degrading aggregates of ubiquitinated proteins from the cell.

7 Nov 2011

Researchers discover two effective cancer killers

Researchers at the University of Southern California have identified two molecules that may be more effective cancer killers than are currently available on the market.

7 Nov 2011

Abzyme Therapeutics licenses SUMOpro from LifeSensors

Abzyme Therapeutics, a new biotechnology company dedicated to developing methods to generate human monoclonal antibodies for the treatment of disease, announced today that they have entered into an exclusive agreement with LifeSensors to license their proprietary protein expression platform, SUMOpro™. Enhanced protein expression is key to the evolution and development of antibodies and the LifeSensors

24 Oct 2011