Faster Breath Analysis with MAX300-LG™ Breath Analyzer

MAX300-LG™ Breath Analyzer

The preferred gas analysis technique for most of the respiratory applications is mass spectrometry. MAX300-LG™ is a fast-acquisition breath analyzer that requires only a minimal sample flow. It is capable of measuring all the compounds present in a sample accurately and delivering data updates instantly. The breath analysis data acquired from this analyzer can be used for physiological and biomedical studies of metabolism and respiration, which focus on gaining insights into the underlying processes that take place in complex biological systems.

Figure 1 illustrates the mass spectrometric measurements taken by the MAX300-LG. From these measurements, it is possible to calculate the metabolic parameters, such as the respiratory quotient (RQ) without using additional instruments for flow measurement.

Figure 1. Mass Spectrometry for indirect calorimetry, a clinic patient inspiring 30% O2 at a normal breathing rate. The MAX300-LG measures all compounds in the sample with 400 full updates per breath. O2 and CO2 measurements are shown, RQ=1 ± 0.007.

Table 1 shows the breath analysis performance of the MAX300-LG. It can be seen from the table values that the MAX300-LG provides highly repeatable data by accurately analyzing all the compounds present in the sample. This, in turn, enhances the accuracy and precision of the calculated metabolic parameters that are obtained from the gas analysis. Besides the components summarized in Table 1, the MAX300-LG can also quantify trace volatiles, including hydrocarbons, ammonia, acetic acid, and formaldehyde, for diagnostic evaluation.

Table 1. Typical MAX300-LG breath analysis performance

Figure 2 shows the MAX-300 LG laboratory gas analyzer that has been configured to quantify various gases and trace volatiles in real time.

Figure 2. The MAX300-LG, laboratory gas analyzer, configured for the real-time quantitation of O2, CO2, N2, H2O, and trace volatiles within inspired and expired breath gas samples.

Salient Features of MAX300-LG

The main features of the MAX300-LG breath analyzer are as follows:

• Quantitative analysis of CO2, O2, N2 and H2O, and other trace volatiles
• Minimal sample flow under 0.04atm cc/s
• Measurement rates up to 5ms per compound
• Sample transit within 0.1s

Breath Analysis with MAX300-LG

In the MAX300-LG, the sample inlet is optimized to perform breath analysis. Different configurations are available for sampling conditions like high pressure, hyperbaric or sub-atmospheric pressures that prevail at high altitudes. Irrespective of the sample pressure, the inlet has been designed in such a way that it automatically adjusts to deliver peak analytical performance. Figure 3 shows the analysis data for sub-atmospheric pressures.

Figure 3. Air analysis at sub-atmospheric pressures. High altitude conditions were simulated at the MAX300-LG inlet. The system automatically adjusts and delivers uniform, high precision data regardless of sample pressure.

The inlet configuration of the MAX300-LG has been specially designed for generating a comprehensive breath-to-breath quantitative profile. It also features fast acquisition software. The analyzer is capable of delivering high precision measurements of all the components present in the sample, and provides a maximum of 50 updates per compound every second. The value of various metabolic parameters like the RQ can be calculated based on the complete sample composition provided by the analyzer without using additional flow measurements. Equation 1 provides the formula for calculating RQ.

Equation 1. The Respiratory Quotient (RQ). Nitrogen is not absorbed during respiration, so the ratio of the volumetric % of N2 in the inspired and expired sample is used to develop an RQ equation in which measured sample flow is not necessary. All O2, CO2, and N2 terms above are measurements of volume %.

References

• Arieli, R. 2010. Mass Spectrometer for Respiratory Research. Respiratory Physiology & Neurobiology. 170, 183-184.

About Extrel CMS, LLC

Extrel is the world’s leading manufacturer of Research and Process Mass Spectrometers, Residual Gas Analyzers (RGA’s), Quadrupole Mass Spectrometry Systems and Components.

Extrel has been providing quadrupole mass spectrometry solutions to our Research and Industrial customers for 50 years. Extrel’s global customers receive the most comprehensive application, technical and onsite support in the industry.

For analysis and control, engineers rely on Quadrupole Mass Spectrometers. Extrel’s MAX300 Quadrupole Mass Spectrometers can be found in pharmaceutical plants around the world.

These advanced systems provide an array of analyses which give engineers the ability to better control processes such as:

• Fermentation Process
• Control Solvent Drying
• Solvent Recovery

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