Biochemistry News and Research

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Scientists tackle huntingtin protein

McMaster scientists are very close to defining small molecule drugs that should be able to redirect the huntingtin protein from accumulating in the wrong place within brain cells, which could potentially translate to a therapy for Huntington's Disease (HD).

29 Jan 2007

Cellular mechanism linked to inflammation and cancer

A team led by biochemists at the University of California, San Diego has found what could be a long-elusive mechanism through which inflammation can promote cancer. The findings may provide a new approach for developing cancer therapies.

28 Jan 2007

Molecular mechanism behind aggregation of amyloid beta peptide due to anesthetics

Inhaled anesthetics commonly used in surgery are more likely to cause the aggregation of Alzheimer's disease-related plaques in the brain than intravenous anesthetics say University of Pittsburgh School of Medicine researchers in a journal article published in Biochemistry.

28 Jan 2007

Minor mistake in protein production at the cellular level may lead to serious neurological diseases

But exactly how the cell avoids such mistakes has remained unclear until now. Researchers at Ohio State University found the mechanism that prevents such errors, and explain their findings in the Proceedings of the National Academy of Sciences.

28 Jan 2007

Anaesthetic spray delays ejaculation by five times longer

Patients with premature ejaculation who used a topical anaesthetic spray were able to delay ejaculation for five times as long, according to a study in the February issue of the urology journal BJU International.

24 Jan 2007

Single protein plays a major role in prion diseases

A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins, creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows.

23 Jan 2007

Enzyme PMR1 reveals kind side

New research shows that a recently discovered enzyme that destroys the messenger RNA (mRNA) for some proteins can also help to protect the mRNA during times of stress. The response might help cancer cells survive chemotherapy and radiation therapy.

10 Jan 2007

New dynamic view of protein dynamics

Scientists from the Institute for Research in Biomedicine (IRB Barcelona), the Life Sciences Programme at the Barcelona Supercomputing Center (BSC) and the National Institute for Bioinformatics (INB) have published a provisional "atlas" of the dynamic behaviour of proteins in the prestigious scientific journal, Proceedings of the National Academy of Sciences.

9 Jan 2007

Olive-pomace oil slows down spread of HIV

Olive oil has become part of the fight against the Human Immunodeficiency Virus (HIV) - the cause of AIDS - thanks to research carried out by the Bionat team, from the University of Granada, headed by Prof. Andres Garcia-Granados, senior lecturer in Organic Chemistry.

8 Jan 2007

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of Hedgehog signaling

One single molecule determines how stem cells in the hair follicle develop. A study at the Sahlgrenska Academy at Göteborg University in Sweden has shown that cells that should give rise to hair can instead give rise to mammary gland cells in mice who lack this molecule.

8 Jan 2007

Compound from olive oil slows down spread of HIV

Olive oil has become part of the fight against the Human Immunodeficiency Virus (HIV) - the cause of AIDS - thanks to research carried out by the Bionat team, from the University of Granada , headed by Prof. Andres García-Granados, senior lecturer in Organic Chemistry.

2 Dec 2006

Brookhaven target compounds to fight SARS

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have set the stage for the rapid identification of compounds to fight against severe acquired respiratory syndrome (SARS), the atypical pneumonia responsible for about 800 deaths worldwide since first recognized in late 2002.

20 Nov 2006

New protein structure found - important for drug discovery

Understanding and replicating the diverse ways in which cellular proteins fold and interconnect is key to understanding life processes and major disorders, such as Parkinson's disease.

15 Nov 2006

Proteins may behave differently in natural environments

When in an environment similar to that in which they exist naturally, proteins and multiprotein assemblies may demonstrate actions or dynamics different than those they exhibit when in the static form in which they are most often studied, said researchers at Baylor College of Medicine in a report in the current issue of the journal Structure.

14 Nov 2006

Brookhaven target new anti-SARS virus drugs

Scientists at Brookhaven National Laboratory have set the stage for the rapid identification of compounds to fight against severe acquired respiratory syndrome (SARS), the atypical pneumonia responsible for about 800 deaths worldwide since first recognized in late 2002.

14 Nov 2006

New method for targeting malignant brain tumors

A new method for targeting malignant brain tumors through inducing the cancerous cells to "commit suicide" has been developed by a team of researchers headed by a Hebrew University of Jerusalem professor of biochemistry.

24 Oct 2006

Flexible interface between DNA ligase and a heterotrimeric sliding clamp supports conformational switching and efficient ligation of DNA

Scientists investigating an important DNA-repair enzyme now have a better picture of the final steps of a process that glues together, or ligates, the ends of DNA strands to restore the double helix.

20 Oct 2006

Blood clotting protein appears to also play a role in fertility

A protein known to play a role in blood clotting and other cell functions is also critical for proper sperm formation in mice, according to researchers from the University of North Carolina at Chapel Hill School of Medicine.

20 Oct 2006

Transport mechanism of bioactive molecule, S1P, identified

Virginia Commonwealth University researchers have identified how a bioactive molecule involved with allergy, inflammation and cancer is transported out of mast cells, according to findings published online this week in the Proceedings of the National Academy of Sciences.

17 Oct 2006