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Research supports polygenic phenotype in schizophrenia

Cumulative genetic risk for schizophrenia has been linked to impaired prefrontal brain activity, in findings that support an additive genetic risk model for a polygenic phenotype.

25 Apr 2013

Study: Melatonin delays symptom onset, reduces mortality in mouse model of ALS

Melatonin injections delayed symptom onset and reduced mortality in a mouse model of the neurodegenerative condition amyotrophic lateral sclerosis, or Lou Gehrig's disease, according to a new study by researchers at the University of Pittsburgh School of Medicine.

25 Apr 2013

Research reveals that molecular madness goes on in the brain after blast exposure

A multicenter study led by scientists at the University of Pittsburgh School of Medicine shows that mild traumatic brain injury after blast exposure produces inflammation, oxidative stress and gene activation patterns akin to disorders of memory processing such as Alzheimer's disease.

25 Apr 2013

MCCIR scientists use video imaging to investigate effectiveness of rituximab in killing cancerous B cells

Scientists from the Manchester Collaborative Centre for Inflammation Research have discovered why a particular cancer drug is so effective at killing cells.

From The University of Manchester 25 Apr 2013

Vertex presents data of telaprevir Phase 3b CONCISE study in people with genotype 1 chronic HCV

Vertex Pharmaceuticals Incorporated today announced new data from an interim analysis of the exploratory global Phase 3b CONCISE study evaluating the potential to shorten total treatment with telaprevir combination therapy to 12 weeks in certain people with genotype 1 chronic hepatitis C virus infection who have the IL28B CC genotype.

25 Apr 2013

Novel approach using Listeria bacteria shows promise against metastatic pancreatic cancer

Researchers at Albert Einstein College of Medicine of Yeshiva University have developed a therapy for pancreatic cancer that uses Listeria bacteria to selectively infect tumor cells and deliver radioisotopes into them.

25 Apr 2013

FDA designates Merck's lambrolizumab as Breakthrough Therapy for advanced melanoma

Merck (NYSE: MRK), known as MSD outside the United States and Canada, announced today that the U.S. Food and Drug Administration has designated lambrolizumab (MK-3475) as a Breakthrough Therapy for the treatment of patients with advanced melanoma.

25 Apr 2013

Cook Medical initiates voluntary recall of Zilver PTX Drug Eluting Peripheral Stent

Based on its investigation into a small number of complaints that the delivery system of the device had separated at the tip of the inner catheter, Cook Medical has initiated a nationwide/global voluntary recall of its Zilver PTX Drug Eluting Peripheral Stent.

25 Apr 2013

Astrocytes more effective in promoting recovery after brain injury

The production of a certain kind of brain cell that had been considered an impediment to healing may actually be needed to staunch bleeding and promote repair after a stroke or head trauma, researchers at Duke Medicine report.

25 Apr 2013

Individuals with MEN1 are at increased risk of developing neuroendocrine tumors

A mutation in a protein called menin causes a hereditary cancer syndrome called MEN1 (multiple endocrine neoplasia type 1).

25 Apr 2013

Personalized PSA testing using genetic variants reduces unnecessary prostate biopsies

With the help of genetics, prostate specific antigen screenings may become more accurate and reduce the number of unnecessary prostate biopsies, according to a new study from Northwestern Medicine.

25 Apr 2013

Individual hydroxymethylcytosine molecules in DNA detected by new method involving chemical modification and nanopore analysis

Changes in the bases that make up DNA act as markers, telling a cell which genes it should read and which it shouldn’t. In the journal Angewandte Chemie, a British team has now introduced a new method that makes it possible to enrich the rare gene segments that contain the modified base hydroxymethylcytosine and to identify individual hydroxymethylcytosine molecules in DNA. Such modifications are associated with autoimmune diseases and cancer.

24 Apr 2013

New research ties mushrooms to potential health outcomes

New research published as abstracts in The FASEB Journal and presented at Experimental Biology 2013 ties mushrooms to potential health outcomes - demonstrating that mushrooms provide more to a dish than just flavor.

24 Apr 2013

Promising development for women with triple-negative breast cancer

Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease, and now a University of Rochester Medical Center team has shown how to exploit tamoxifen's secondary activities so that it might work on more aggressive breast cancer.

24 Apr 2013

Researchers decode toggle switch that can stimulate fat burning

For a long time, scientists have dreamt of converting undesirable white fat cells into brown fat cells and thus simply have excess pounds melt away. Researchers at the University of Bonn have now gotten a step closer to this goal: They decoded a "toggle switch" in mice which can significantly stimulate fat burning.

24 Apr 2013

Nanogels to attack lupus: an interview with Dr Look and Dr Fahmy, Yale University

Nanogels are synthetic particles that can be used for drug delivery. They are approximately 100 nm to 200 nm in diameter, and are made from safe, biocompatible materials: a gel-like interior and a lipid exterior.

24 Apr 2013

Research project to identify mechanisms underlying effects of cancer drug interferon-α

The immune system plays a decisive role in the fight against tumor cells. However, when tumor cells themselves prevent activation of the immune system, the immune system fails to destroy cancer cells.

24 Apr 2013

Study: Nearly two-thirds of children receiving stem cell transplants return to hospital within six months

Nearly two-thirds of children receiving stem cell transplants returned to the hospital within six months for treatment of unexplained fevers, infections or other problems, according to a study performed at Dana-Farber/Children's Hospital Cancer Center in Boston.

24 Apr 2013

CytRx reaches agreement with FDA for aldoxorubicin Phase 3 trial for treatment of soft tissue sarcomas

CytRx Corporation, a biopharmaceutical research and development company specializing in oncology, announced today that it has reached an agreement with the U.S. Food and Drug Administration under a special protocol assessment for a global pivotal Phase 3 trial with aldoxorubicin as a treatment for patients with soft tissue sarcomas who have relapsed or were refractory following prior treatment with chemotherapy.

24 Apr 2013

Thermo Scientific Scientific launches HyPerforma SUM DS 300 system for multiple uses

Thermo Fisher Scientific Inc., the world leader in serving science, today introduced the Thermo Scientific HyPerforma Single-Use Mixer DS 300 system, an innovative, cost-effective single-use mixer ideal for pilot-scale liquid preparations for vaccine and biologic manufacturing.

From Thermo Fisher Scientific Inc. 24 Apr 2013

Cell News and Research

Research supports polygenic phenotype in schizophrenia

Study: Melatonin delays symptom onset, reduces mortality in mouse model of ALS

Research reveals that molecular madness goes on in the brain after blast exposure

MCCIR scientists use video imaging to investigate effectiveness of rituximab in killing cancerous B cells

Vertex presents data of telaprevir Phase 3b CONCISE study in people with genotype 1 chronic HCV

Novel approach using Listeria bacteria shows promise against metastatic pancreatic cancer

FDA designates Merck's lambrolizumab as Breakthrough Therapy for advanced melanoma

Cook Medical initiates voluntary recall of Zilver PTX Drug Eluting Peripheral Stent

Astrocytes more effective in promoting recovery after brain injury

Individuals with MEN1 are at increased risk of developing neuroendocrine tumors

Personalized PSA testing using genetic variants reduces unnecessary prostate biopsies

Individual hydroxymethylcytosine molecules in DNA detected by new method involving chemical modification and nanopore analysis

New research ties mushrooms to potential health outcomes

Promising development for women with triple-negative breast cancer

Researchers decode toggle switch that can stimulate fat burning

Nanogels to attack lupus: an interview with Dr Look and Dr Fahmy, Yale University

Research project to identify mechanisms underlying effects of cancer drug interferon-α

Study: Nearly two-thirds of children receiving stem cell transplants return to hospital within six months

CytRx reaches agreement with FDA for aldoxorubicin Phase 3 trial for treatment of soft tissue sarcomas

Thermo Scientific Scientific launches HyPerforma SUM DS 300 system for multiple uses

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Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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