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Researchers pinpoint new mechanism that potently activates T-cells in leprosy

UCLA researchers pinpointed a new mechanism that potently activates T-cells, the group of white blood cells that play a major role in fighting infections.

26 Mar 2012

Heart attack may soon be predicted by a simple blood test

Researchers have found a simple test that could predict whether a patient is about to have a heart attack. They used a blood sample to detect cells that have sloughed off of damaged blood vessel walls to predict a heart attack.

25 Mar 2012

New method to easily identify cause of rare diseases

Sanford Health Children's Research Center researcher, Kyle Roux, PhD, has revealed a new method of research that will allow the cause of disease—particularly rare diseases—to become more easily identified.

23 Mar 2012

Testosterone may play a role in treatment of triple negative breast cancer

Could blocking a testosterone receptor lead to a new way to treat an aggressive form of breast cancer? That's a question researchers at Mayo Clinic in Arizona and the Translational Genomics Research Institute (TGen) are exploring. Preliminary results of a Mayo Clinic - TGen collaborative study shows the testosterone receptor may be a potential target to attack in treating triple negative breast cancer (TNBC).

23 Mar 2012

Fraunhofer FIT software rapidly analyzes complex biological processes

At Analytica 2012, Fraunhofer FIT presents software that supports the search for new active pharmaceutical ingredients of cancer drugs. Through a high degree of parallelization, the software can analyze complex biological processes very fast, even with large amounts of data.

23 Mar 2012

Deficiency of Mitofusin 2 protein leads to insulin resistance, glucose intolerance

The study shows that the lack of Mitofusin 2 in mice produces insulin resistance and glucose intolerance, the main causes of diabetes.

23 Mar 2012

Combination of everolimus and exemestane reduces spread of cancer in the bone

Results from a phase III clinical trial evaluating a new treatment for breast cancer in post-menopausal women show that the combination of two cancer drugs, everolimus and exemestane, significantly improves bone strength and reduces the chances of cancer spreading (metastasising) in the bone.

23 Mar 2012

Multiresistant bacteria withstand wastewater treatment processes

Large quantities of antibiotic-resistant bacteria enter the environment via municipal - and especially hospital - wastewater streams. Although wastewater treatment plants reduce the total number of bacteria, the most hazardous - multiresistant - strains appear to withstand or even to be promoted by treatment processes. This was demonstrated by Eawag researchers in a study carried out in Lake Geneva, near Lausanne.

23 Mar 2012

Max Planck researchers obtain somatic stem cells from fully differentiated somatic cells

Breaking new ground, scientists at the Max Planck Institute for Molecular Biomedicine in M-nster, Germany, have succeeded in obtaining somatic stem cells from fully differentiated somatic cells. Stem cell researcher Hans Sch-ler and his team took skin cells from mice and, using a unique combination of growth factors while ensuring appropriate culturing conditions, have managed to induce the cells' differentiation into neuronal somatic stem cells.

23 Mar 2012

UC Riverside to study molecular basis of hormonal regulation of mosquito reproduction

Female mosquitoes require energy for their egg development, which they acquire from vertebrate blood. But by sucking on blood, they become vectors of numerous disease pathogens of human and domestic animals. If the mechanisms that govern their egg production are better understood, novel approaches to controlling the reproduction and population of mosquitoes can be devised.

23 Mar 2012

Immediate skull reconstruction aggravates brain damage in TBI model

Immediate skull reconstruction following trauma that penetrates or creates an indentation in the skull can aggravate brain damage inflicted by the initial injury, a study by a University of South Florida research team reports.

23 Mar 2012

OncoSec to present data from head and neck cancer studies at two upcoming conferences

OncoSec Medical Incorporated., which is developing its advanced-stage OncoSec Medical System (OMS) ElectroOncology therapies to treat solid tumor cancers, today announced that the company has been selected to present data from its Phase III and IV head and neck cancer studies at two upcoming conferences.

23 Mar 2012

Scientists artificially derive brain stem cells from connective tissue of mice

These stem cells can reproduce and be converted into various types of brain cells. To date, only reprogramming in brain cells that were already fully developed or which had only a limited ability to divide was possible. The new reprogramming method presented by the Bonn scientists and submitted for publication in July 2011 now enables derivation of brain stem cells that are still immature and able to undergo practically unlimited division to be extracted from conventional body cells.

23 Mar 2012

Blocking PFKFB4 enzyme could prevent growth of prostate cancer cells

Cancer Research UK scientists have discovered how blocking a key enzyme, which helps convert glucose into energy, could provide a new way to kill prostate cancer cells, according to a study published in the journal Cancer Discovery.

23 Mar 2012

tAI could predict sensitivity to chemotherapy in patients with triple-negative breast cancer

Scientists have uncovered a marker of DNA damage that could predict who will respond to platinum-based chemotherapy drugs like cisplatin or carboplatin.

23 Mar 2012

Study provides important clue in type 1 diabetes

In type 1 diabetes (T1D), pancreatic beta cells die from a misguided autoimmune attack, but how and why that happens is still unclear. Now, JDRF-funded scientists from the Indiana University School of Medicine have found that a specific type of cellular stress takes place in pancreatic beta cells before the onset of T1D, and that this stress response in the beta cell may in fact help ignite the autoimmune attack.

23 Mar 2012

PFKFB4 gene leads to excessive growth of prostate cancer cells

Cancer cell metabolism may present a new target for therapy as scientists have uncovered a possible gene that leads to greater growth of prostate cancer cells.

23 Mar 2012

Verapamil drug may reverse diabetes-related death of pancreatic beta cells

A common high-blood-pressure medication appears to reverse the diabetes-related death of pancreatic beta cells, according to a University of Alabama at Birmingham study published today in the journal Diabetes.

23 Mar 2012

Study identifies abnormal brain gene expression patterns in autism

A study led by Eric Courchesne, PhD, director of the Autism Center of Excellence at the University of California, San Diego School of Medicine has, for the first time, identified in young autism patients genetic mechanisms involved in abnormal early brain development and overgrowth that occurs in the disorder. The findings suggest novel genetic and molecular targets that could lead to discoveries of new prevention strategies and treatment for the disorder.

23 Mar 2012

A rare forum on stem cell biology, engineering and clinical translation

On March 23, during the 41st Annual Meeting & Exhibition of the American Association for Dental Research (AADR), held in conjunction with the 36th Annual Meeting of the Canadian Association for Dental Research, a symposium titled "TMJ: Stem Cell Biology and Engineering toward Clinical Translation" will provide a rare forum for multidisciplinary discussion of the biology, engineering and clinical translation of fundamental discoveries towards novel clinical therapy.

22 Mar 2012