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Researchers discover mechanism by which lead alters nerve cells in the brain

Exposure to lead wreaks havoc in the brain, with consequences that include lower IQ and reduced potential for learning. But the precise mechanism by which lead alters nerve cells in the brain has largely remained unknown.

1 Mar 2012

NEJM publishes results from two Jakafi Phase III studies on MF

The New England Journal of Medicine (NEJM) today published results from two Phase III studies (COMFORT-I and COMFORT-II) of Jakafi (ruxolitinib), a JAK1 and JAK2 inhibitor recently approved by the Food and Drug Administration (FDA) for the treatment of intermediate or high-risk myelofibrosis.

1 Mar 2012

Researchers observe how cholera decimates competing bacteria and human cells

Bacteria live in a state of perpetual warfare, with different species battling for dominion over their competitors and when pathogen, over their infected host. New research suggests that the human pathogen Vibrio cholerae, which causes the disease cholera, kills off its microbial rivals by jabbing them with a spring-loaded poison dagger.

1 Mar 2012

Brain mitochondria are dysfunctional in early-stage Alzheimer's

Mitochondria -- subunits inside cells that produce energy -- have long been thought to play a role in Alzheimer's disease. Now Mayo Clinic researchers using genetic mouse models have discovered that mitochondria in the brain are dysfunctional early in the disease.

1 Mar 2012

First clinical assessment of how interferon fights infections in people

A drug once taken by people with HIV/AIDS but long ago shelved after newer, modern antiretroviral therapies became available has now shed light on how the human body uses its natural immunity to fight the virus—work that could help uncover new targets for drugs.

1 Mar 2012

New NOSH-aspirin appears more effective against cancer

Scientists have combined two new "designer" forms of aspirin into a hybrid substance that appears more effective than either of its forebears in controlling the growth of several forms of cancer in laboratory tests. Their report on the new NOSH-aspirin, so named because it releases nitric oxide (NO) and hydrogen sulfide (H2S), appears in the journal ACS Medicinal Chemistry Letters.

29 Feb 2012

Walnuts associated with better memory scores and cognitive function

Do you recall what you ate for breakfast today or dinner last night? According to new research, you may have a better chance of remembering if you include walnuts. Recent findings published in the Journal of Alzheimer's Disease report walnut consumption in a Mediterranean diet is associated with better memory scores and cognitive function.

29 Feb 2012

Alzheimer's disease drugs may act like a bad electrician

Alzheimer's disease drugs now being tested in clinical trials may have potentially adverse side effects, according to new Northwestern Medicine research. A study with mice suggests the drugs could act like a bad electrician, causing neurons to be miswired and interfering with their ability to send messages to the brain.

29 Feb 2012

Simple and accurate device to study malaria

University of British Columbia researcher Hongshen Ma has developed a simple and accurate device to study malaria, a disease that currently affects 500 million people per year worldwide and claims a million lives.

29 Feb 2012

Wiley-Blackwell to publish 44 new important journals in 2012

In 2012 Wiley-Blackwell, the Scientific, Technical, Medical, and Scholarly publishing business of John Wiley & Sons, Inc., will begin publishing 44 titles new to its journal program, including 16 new launches and 40 journals published in collaboration with societies or other organizations.

29 Feb 2012

Scientists discover that sperm do not function like olfactory cells

According to a 2003 study by German and American scientists, a component of the Lily of the Valley scent known as Bourgeonal alters the calcium balance of human sperm and attracts the sperm. The "Lily of the Valley phenomenon" - also the title of a book about smelling - was born as a result of this discovery that sperm act as swimming olfactory cells which follow a "scent trail" laid by the egg. However, a detailed explanation for the Lily of the Valley phenomenon remained illusive as neither Bourgeonal nor other scents could be identified in the female sex organ.

29 Feb 2012

Tiny molecule might help protect pancreas from cancer

A tiny molecule might help protect the pancreas from deadly disease and cancer. Tackling a mysterious process: There is a feeling that neglected cancers need more research and Pancreatic cancer is one of the least studied. Today, the survival rate is 3% for five years. Professor Petersen, at the School of Biosciences at Cardiff University, hopes his team's research can change that.

29 Feb 2012

Shire, arGEN-X partner to create novel antibodies against rare diseases

arGEN-X, a biopharmaceutical company focused on the discovery and development of human monoclonal antibodies from its proprietary SIMPLE Antibody platform, announces today that it has entered into an alliance with Shire to create novel therapeutic antibody products against multiple targets submitted by Shire.

29 Feb 2012

Cancer survival rates on the rise in Northern Ireland

Despite the rising incidence of cancer in Northern Ireland, the number of people surviving the disease in the country is increasing significantly year on year.

29 Feb 2012

WUSM to study children with weakened immune systems

Not all viruses make us sick. But which ones are friends and which ones are foes? Researchers at Washington University School of Medicine in St. Louis have received a five-year, $3.3 million grant to study children with weakened immune systems to identify the viruses that make children sick.

29 Feb 2012

Cannabinoids may be a target for new strategies in cancer treatment

Cannabis-like substances that are produced by the body have both therapeutic and harmful properties, besides their well-known intoxicating effects, and the body's cannabinoid system may be a target for new strategies in cancer treatment.

29 Feb 2012

Genome sequencing helps characterize S. aureus ST398-NM strain

Using genome sequencing and household surveillance, National Institutes of Health (NIH) scientists and their colleagues from Columbia University Medical Center and St. George's University of London have pieced together how a newly emerging type of Staphylococcus aureus bacteria has adapted to transmit more easily among humans.

29 Feb 2012

XL888 inhibitor can prevent vemurafenib resistance in melanoma patients

Researchers at Moffitt Cancer Center in Tampa, Fla., and colleagues in California have found that the XL888 inhibitor can prevent resistance to the chemotherapy drug vemurafenib, commonly used for treating patients with melanoma.

29 Feb 2012

FDA accepts Tau Therapeutics' mibefradil IND for treatment of cancer

Tau Therapeutics LLC, a pharmaceutical company developing T-type calcium channel inhibitors for the treatment of solid tumors, announced today that its investigational new drug application (IND 109196) for its novel drug mibefradil has been accepted by the Food and Drug Administration (FDA).

28 Feb 2012

New research shows how motor neurones are produced

The quest for treatments for motor neurone disease, spinal cord injury and strokes could be helped by new research that shows how key cells are produced.

28 Feb 2012