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Lawson researchers exploit hunger hormone to identify prostate cancer

Non-invasive imaging detects prostate cancer earlier than ever before, but can't accurately distinguish between malignant and benign disease. According to Lawson Health Research Institute's Drs. John Lewis and Len Luyt, a new molecular imaging probe could be the answer.

9 Dec 2011

Positive results from Synta's Ganetespib Phase 2 trial on HER2-positive and triple negative mBC

Synta Pharmaceuticals Corp. - Ganetespib, a potent, second generation Hsp90 inhibitor, has demonstrated clinical activity in heavily pre-treated patients with HER2-positive and triple negative metastatic breast cancer according to Phase 2 clinical trial results presented by researchers from Memorial Sloan-Kettering Cancer Center at the San Antonio Breast Cancer Symposium.

9 Dec 2011

Combination of MEK inhibitors and nilotinib can overcome CML resistance to targeted drug

Cancer Research UK-funded scientists at The Institute of Cancer Research (ICR) have revealed a technique to kill chronic myeloid leukaemia (CML) cells that have stopped responding to a targeted drug, according to research published in Cancer Cell today.

9 Dec 2011

Pharmacyclics, Janssen partner to develop and market PCI-32765 anti-cancer compound

Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson, announced today that it has executed an agreement with Pharmacyclics, Inc. to jointly develop and market the anti-cancer compound, PCI-32765.

9 Dec 2011

Toxins in Danish mushroom are effective against cancer cells

Researchers at the University of Copenhagen have explored the active principles of a Danish mushroom and found that some of the substances it contains are particularly toxic towards cancer cells. The goal is to synthesise and refine substances in the mushroom that may be useful in future drug development.

9 Dec 2011

ChemoCentryx commences CCX140 Phase II trial in diabetic nephropathy

ChemoCentryx, Inc. today announced the initiation of a Phase II clinical trial for CCX140, an orally-administered small molecule for the treatment of diabetic kidney disease.

9 Dec 2011

Considering varying extent to which genes are turned on or off can help develop personalised, predictive medicines

The vast majority of genetic disorders (schizophrenia or breast cancer, for example) have different effects in different people. Moreover, an individual carrying certain mutations can develop a disease, whereas another one with the same mutations may not. This holds true even when comparing two identical twins who have identical genomes. But why does the same mutation have different effects in different individuals?

8 Dec 2011

Ixabepilone-sunitinib combination holds potential against chemotherapy-resistant ovarian cancer

The use of two drugs never tried in combination before in ovarian cancer resulted in a 70 percent destruction of cancer cells already resistant to commonly used chemotherapy agents, say researchers at Mayo Clinic in Florida.

8 Dec 2011

MS may progress from outermost layers of brain to its deep parts

Multiple sclerosis (MS) may progress from the outermost layers of the brain to its deep parts, and isn't always an "inside-out" process as previously thought, reported a new collaborative study from researchers at the Mayo Clinic and the Cleveland Clinic.

8 Dec 2011

Viewpoints: Insurance safety net; Orszag on shift in health plans

In this country, three subjects that are guaranteed to generate a heated debate are religion, politics and, you guessed it, health insurance. Of the first two, Mark Twain observed that "people's beliefs and convictions are in almost every case gotten at second-hand."

8 Dec 2011

New gene editing technique can heal sickle cell patients with their own cells

Researchers at the Salk Institute for Biological Studies have developed a way to use patients' own cells to potentially cure sickle cell disease and many other disorders caused by mutations in a gene that helps produce blood hemoglobin.

8 Dec 2011

Israeli Nobel Laureate receives AvH's Humboldt Research Award

The Israeli Nobel Laureate Aaron Ciechanover has been named one of the recipients of the Humboldt Research Award of the Alexander von Humboldt Foundation.

8 Dec 2011

Scientists discover genetic trigger that makes stem cells differentiate in nose epithelia

University of California, Berkeley, neuroscientists have discovered a genetic trigger that makes the nose renew its smell sensors, providing hope for new therapies for people who have lost their sense of smell due to trauma or old age.

8 Dec 2011

BCX4945 proves effective at clearing malaria infections

An antimalarial agent developed by researchers at Albert Einstein College of Medicine of Yeshiva University proved effective at clearing infections caused by the malaria parasite most lethal to humans - by literally starving the parasites to death. The novel research, carried out on a small number of non-human primates, could bolster efforts to develop more potent therapies against one of the world's leading killers.

8 Dec 2011

First study to identify molecular mechanism that links inflammation to cancer epigenetics

Johns Hopkins Kimmel Cancer Center scientists report that sharp rises in levels of reactive oxygen molecules, and the inflammation that results, trigger biochemical changes that silence genes in a pattern often seen in cancer cells. The researchers confirmed this gene-silencing effect in mice that develop inflammation-induced colon cancer.

8 Dec 2011

Research: lncRNA affects apoptosis and plays a role in RBC development

A long non-coding RNA (lncRNA) regulates programmed cell death during one of the final stages of red blood cell differentiation, according to Whitehead Institute researchers. This is the first time a lncRNA has been found to play a role in red blood cell development and the first time a lncRNA has been shown to affect programmed cell death.

8 Dec 2011

Visual cortex cells play a key role in reconstructing 3D shape

As dizzying as it may sound, the impression that we are living in a 3D world is actually a continuous fabrication of our brains. When we look at things, the world gets projected onto the retina and information about the third dimension is lost - a bit like when a 3D object casts a shadow onto a flat, 2D wall. Somehow the brain is able to reconstruct the third dimension from the image, allowing us to experience a convincing 3D world.

8 Dec 2011

Positive results from Genentech's pertuzumab plus Herceptin Phase III study on HER2-positive mBC

Genentech, a member of the Roche Group, today announced results from CLEOPATRA, the first randomized Phase III study of the investigational HER2-targeted medicine pertuzumab.

8 Dec 2011

Updated data from Novartis Afinitor plus everolimus Phase III study on advanced breast cancer

Updated results of a Phase III study of Afinitor (everolimus) tablets plus exemestane, a hormonal therapy, show everolimus provided additional time women with advanced breast cancer lived without their disease progressing.

8 Dec 2011

First realistic 3-D diagram of thalamocortical column in rodent brain

Researchers from the lab of Nobel laureate Bert Sakmann, MD, PhD at the Max Planck Florida Institute (MPFI) are reporting that, using a conceptually new approach and state-of-the-art research tools, they have created the first realistic three-dimensional diagram of a thalamocortical column in the rodent brain.

8 Dec 2011

Cell News and Research

Lawson researchers exploit hunger hormone to identify prostate cancer

Positive results from Synta's Ganetespib Phase 2 trial on HER2-positive and triple negative mBC

Combination of MEK inhibitors and nilotinib can overcome CML resistance to targeted drug

Pharmacyclics, Janssen partner to develop and market PCI-32765 anti-cancer compound

Toxins in Danish mushroom are effective against cancer cells

ChemoCentryx commences CCX140 Phase II trial in diabetic nephropathy

Considering varying extent to which genes are turned on or off can help develop personalised, predictive medicines

Ixabepilone-sunitinib combination holds potential against chemotherapy-resistant ovarian cancer

MS may progress from outermost layers of brain to its deep parts

Viewpoints: Insurance safety net; Orszag on shift in health plans

New gene editing technique can heal sickle cell patients with their own cells

Israeli Nobel Laureate receives AvH's Humboldt Research Award

Scientists discover genetic trigger that makes stem cells differentiate in nose epithelia

BCX4945 proves effective at clearing malaria infections

First study to identify molecular mechanism that links inflammation to cancer epigenetics

Research: lncRNA affects apoptosis and plays a role in RBC development

Visual cortex cells play a key role in reconstructing 3D shape

Positive results from Genentech's pertuzumab plus Herceptin Phase III study on HER2-positive mBC

Updated data from Novartis Afinitor plus everolimus Phase III study on advanced breast cancer

First realistic 3-D diagram of thalamocortical column in rodent brain

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Expanding research and clinical options for children with cancer

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