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New assay simultaneously visualize gene number, protein expression in individual cells

Researchers have discovered a method for simultaneously visualizing gene number and protein expression in individual cells. The fluorescence microscopy technique could permit a detailed analysis of the relationship between gene status and expression of the corresponding protein in cells and tissues, and bring a clearer understanding of cancer and other complex diseases, according to researchers who led the study

23 Sep 2011

UCLA's gene-based imaging system can accurately detect metastatic prostate cancers

Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed a way to image the spread of a particularly dangerous form of prostate cancer earlier than conventional imaging in use today, which may allow oncologists to find and treat these metastases more quickly and give patients a better chance at survival.

23 Sep 2011

Researchers discover cellular origins of breast cancer

Identifying the cellular origins of breast cancer might lead to earlier diagnosis and more efficient management of the disease. New research led by Charlotte Kuperwasser of Tufts University School of Medicine (TUSM) has determined that common forms of breast cancer originate from breast cells known as luminal epithelial cells while rarer forms of breast cancer, such as metaplastic carcinomas, originate from basal epithelial cell types.

23 Sep 2011

Cyclin E plays a crucial role in the formation of nerve connections

Scientists at Dana-Farber Cancer Institute and Harvard Medical School have found that a common cancer protein leads a second, totally different life in normal adult brain cells: It helps regulates memory formation and may be implicated in Alzheimer's disease.

23 Sep 2011

Adeno-associated virus type 2 kills human breast cancer cells in lab

A nondisease-causing virus kills human breast cancer cells in the laboratory, creating opportunities for potential new cancer therapies, according to Penn State College of Medicine researchers who tested the virus on three different breast cancer types that represent the multiple stages of breast cancer development.

23 Sep 2011

Cedars-Sinai inaugurates new facility to generate induced pluripotent stem cells

The Cedars-Sinai Regenerative Medicine Institute has opened a new Induced Pluripotent Stem Cell (iPSC) Core Facility to produce powerful cells capable of making all tissues of the body from adult human skin cells.

23 Sep 2011

Viewpoints: Ron Paul, USA Today on individual mandate; NYT's Greenhouse on court challenges to health law

Massachusetts leads the nation in health insurance coverage of its citizens, and Texas is dead last. You'd think that former Massachusetts governor Mitt Romney would be bragging about his role in making his state No. 1, and that Texas Gov. Rick Perry would be embarrassed by how poorly his state is doing. But that's not how the script is playing out … That's odd, though, because the mandate was born as a conservative response to President Clinton's much maligned health reform proposal.

23 Sep 2011

Acetylon initiates ACY-1215 Phase 1-2a clinical trial for multiple myeloma

Acetylon Pharmaceuticals today announced the initiation of patient treatments in a three-part Phase 1-2a clinical trial of ACY-1215, an oral Class II histone deacetylase (HDAC) inhibitor, in adults with relapsed and relapsed/refractory multiple myeloma.

22 Sep 2011

ACT receives UK MHRA clearance for hESC-derived RPE cell trial for Stargardt's Macular Dystrophy

Advanced Cell Technology, Inc., a leader in the field of regenerative medicine, announced today that it has received clearance from the U.K. Medicines and Healthcare products Regulatory Agency to begin treating patients as part of a Phase 1/2 clinical trial for Stargardt's Macular Dystrophy using retinal pigment epithelium (RPE) derived from human embryonic stem cells.

22 Sep 2011

Quidel, Life Technologies to distribute and commercialize molecular diagnostics in Europe

Life Technologies Corporation today announced that the company has signed an agreement with Quidel Corporation to distribute and commercialize molecular diagnostic assays for the European market.

22 Sep 2011

Virginia G. Piper, TGen and Scottsdale Healthcare begin AP26113 Phase 1 study in NSCLC

Patients at Virginia G. Piper Cancer Center Clinical Trials are the first in the nation to participate in a clinical trial to determine the safety, tolerability and preliminary activity of an investigational drug that targets cell-signaling proteins associated with the most common form of lung cancer, as well as other forms of cancer such as lymphomas and neuroblastoma.

22 Sep 2011

Wnt signaling pathway plays an important role in early-onset dementia

No cure exists for frontotemporal dementia, which strikes between the ages of 40 and 64 and accounts for at least one in four cases of early-onset dementia. Caused by the death of cells in the front and sides of the brain, the disease can lead to dramatic changes in a patient's personality and behavior, including the loss of the ability to communicate.

22 Sep 2011

Researchers analyse effects of BPA in an in-vitro culture of ovaries

Researchers at Universitat Aut-noma de Barcelona, in collaboration with the Vall d'Hebron Hospital Fetal Tissue Bank, the Department of Gynaecology and the Research Unit of Paediatric Endocrinology, analysed the effects of Bisphenol A (BPA), a polymer widely used to manufacture plastics, in an in vitro culture of ovaries.

22 Sep 2011

Early ART cost effectiveness in resource-poor settings

A study published in PLoS Medicine shows "that the new WHO guidelines for early [antiretroviral treatment (ART)] initiation can be cost-effective in resource-poor settings, information that should help policymakers in developing countries allocate their often limited resources," according to a PLoS press release.

22 Sep 2011

Molecular pathways could play important role in fight against obesity and diabetes

Researchers at the Joslin Diabetes Center have identified for the first time two molecular pathways that are critical to activating a type of "good" fat found in the body, a discovery that could play an important role in the fight against obesity and diabetes.

22 Sep 2011

Stanford Hospital & Clinics inaugurates new Brain Tumor Center

Today, Stanford Hospital & Clinics inaugurates its new Brain Tumor Center, framing its considerable corps of top-notch specialists into a treatment team driven by expertise, experience and compassion.

22 Sep 2011

Cornell researchers identify how T. gondii controls host's immune system

Toxoplasma gondii parasites can invade your bloodstream, break into your brain and prompt behavioral changes from recklessness to neuroticism. These highly contagious protozoa infect more than half the world's population, and most people's immune systems never purge the intruders.

22 Sep 2011

Families help identify new gene for motor neuron disease

Families suffering from a history of motor neuron disease have helped an international scientific team locate a new gene linked to the incurable disease.

22 Sep 2011

Early ART can be cost-effective and decrease mortality in HIV patients

Researchers at Weill Cornell Medical College and GHESKIO have shown that early treatment of HIV not only saves lives but is also cost-effective. Results are published in today's edition of PLoS Medicine.

22 Sep 2011

NEJM publishes Boehringer Ingelheim's BIBF 1120 phase II trial on IPF

Boehringer Ingelheim's investigational tyrosine kinase inhibitor (TKI) BIBF 1120 demonstrated a positive trend in reducing lung function decline in patients with idiopathic pulmonary fibrosis (IPF), according to phase II clinical trial results published today online in the New England Journal of Medicine.

22 Sep 2011

Cell News and Research

New assay simultaneously visualize gene number, protein expression in individual cells

UCLA's gene-based imaging system can accurately detect metastatic prostate cancers

Researchers discover cellular origins of breast cancer

Cyclin E plays a crucial role in the formation of nerve connections

Adeno-associated virus type 2 kills human breast cancer cells in lab

Cedars-Sinai inaugurates new facility to generate induced pluripotent stem cells

Viewpoints: Ron Paul, USA Today on individual mandate; NYT's Greenhouse on court challenges to health law

Acetylon initiates ACY-1215 Phase 1-2a clinical trial for multiple myeloma

ACT receives UK MHRA clearance for hESC-derived RPE cell trial for Stargardt's Macular Dystrophy

Quidel, Life Technologies to distribute and commercialize molecular diagnostics in Europe

Virginia G. Piper, TGen and Scottsdale Healthcare begin AP26113 Phase 1 study in NSCLC

Wnt signaling pathway plays an important role in early-onset dementia

Researchers analyse effects of BPA in an in-vitro culture of ovaries

Early ART cost effectiveness in resource-poor settings

Molecular pathways could play important role in fight against obesity and diabetes

Stanford Hospital & Clinics inaugurates new Brain Tumor Center

Cornell researchers identify how T. gondii controls host's immune system

Families help identify new gene for motor neuron disease

Early ART can be cost-effective and decrease mortality in HIV patients

NEJM publishes Boehringer Ingelheim's BIBF 1120 phase II trial on IPF

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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