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Niiki Pharma announces positive data from ongoing trial of novel anti-cancer agent NKP-1339

Niiki Pharma Inc. announced interim results from the ongoing Phase I clinical trial of its lead product, NKP-1339. NKP-1339 is a first-in-class transferrin targeted small molecule that down-regulates GRP78, a key regulator of mis-folded protein processing and a tumor survival factor.

20 Sep 2011

A code beyond DNA: Modified tRNA bases are characteristic of species

Our genetic code consists of four “letters” in the form of the nucleobases in our DNA and RNA. Three letters together form a “word” that are translated into an amino acid by tRNA and combined into proteins. Special markings subdivide the gene into active and inactive regions. A third possible level of information has so far received less attention: the chemical modification of tRNA nucleobases. In the journal Angewandte Chemie Thomas Carell and a team at the University of Munich have now demonstrated that tRNA modification profiles can be used for the characterization of species and the differentiation of pathogenic and nonpathogenic bacterial strains.

20 Sep 2011

Vigorous exercise results in stronger bones, reduced diabetes risk and less visceral fat

Cells in bone, fat and the pancreas appear to be talking to each other and one thing they likely are saying is, "Get moving."

20 Sep 2011

New trick of tumors

Tumors have an arsenal of tricks to help them sidestep the immune system. A study published on September 19 in the Journal of Experimental Medicine reveals a new trick—the ability to keep tumor-fighting T cells out by disabling a T cell-attracting protein within the tumor core.

20 Sep 2011

Liposomes block HIV infection in early tests

Could engineered fatty particles help prevent AIDS? Liposomes block HIV infection in early tests; could be a cost-effective preventive for developing countries

20 Sep 2011

Immune system uses zinc to destroy tuberculosis bacillus, E. coli

A new natural defense mechanism against infections has been evidenced by an international team led by researchers from CNRS, Inserm, the Institut Pasteur and the Université Paul Sabatier - Toulouse III.

20 Sep 2011

Walnuts improve inferential reasoning skills among students

Recently published research in the September issue of British Journal of Nutrition suggests students may want to grab a handful of walnuts before taking that next exam. According to the study, students consuming walnuts improved their inferential reasoning skills - the ability to discover true from false.

20 Sep 2011

Medication non-adherence interventions should be based on personal systems approach

For medications to be effective, they must be taken in the correct dosage at the right time, as prescribed by healthcare providers. The World Health Organization estimates that half of patients take their medications incorrectly, costing the U.S. health care system and consumers about $300 billion each year.

20 Sep 2011

Scientists discover how liver destroys immune T-cells

Scientists at the Centenary Institute in Sydney have seen for the first time (in mice) how the liver goes independent, engulfing and destroying the body's defence troops-T-cells.

20 Sep 2011

TJUH adopts new equipment from Roche Diagnostics for laboratory testing services

Thomas Jefferson University Hospital (TJUH) is advancing its laboratory testing services with new state-of-the-art equipment from Roche Diagnostics designed to help labs increase their testing capacity and deliver reliable results with greater efficiency.

From Roche Sequencing and Life Science 20 Sep 2011

Combination of lunasin and oxaliplatin prevents colon cancer from metastasis

A University of Illinois study reports a promising new weapon in treating metastatic colon cancer, particularly in patients who have developed resistance to chemotherapy.

20 Sep 2011

Scientists identify oldest known DNA regulatory region

A team of scientists has discovered the oldest known DNA regulatory region, as reported in an article in the journal Proceedings of the National Academies of Sciences.

20 Sep 2011

Vitrolife obtains Chinese SFDA approval for aspiration needles and micropipettes

Vitrolife has obtained regulatory approval from the Chinese SFDA (State Food and Drug Administration) for aspiration needles and micropipettes used for infertility treatment.

20 Sep 2011

FoxM1 protein plays a critical role in development of medulloblastomas

Medulloblastomas constitute the most frequent class of malignant childhood brain tumor. Tumors of this type arise due to the uncontrolled proliferation of immature nerve cells in the developing brain, and there is no targeted treatment available.

20 Sep 2011

UNC researchers reveal genetic underpinnings of Foxp3-expressing regulatory T cells

Within the immune system, a subtle balance exists between the cells that destroy alien pathogens and those that preserve the body's own tissues. When the balance gets out of whack, the cells that normally target viruses or bacteria can go astray, attacking innocent cells and causing autoimmune and inflammatory disease.

20 Sep 2011

New UCSB technology can identify cancerous prostate cells

A team of researchers at UC Santa Barbara has developed a breakthrough technology that can be used to discriminate cancerous prostate cells in bodily fluids from those that are healthy.

20 Sep 2011

UNC researchers develop technique that can observe cellular intricacies of CF

When researchers discovered the primary genetic defect that causes cystic fibrosis (CF) back in 1989, they opened up a new realm of research into treatment and a cure for the disease. Since then, scientists have been able to clone the defective gene and study its effects in animals. Now researchers at the University of North Carolina at Chapel Hill have developed a technique for observing the defects at work in human tissue donated by patients with CF.

20 Sep 2011

Keryx completes enrollment in Zerenex Phase 3 long-term study for hyperphosphatemia

Keryx Biopharmaceuticals today announced completion of patient enrollment in the long-term study component of its Phase 3 registration program of Zerenex, the Company's ferric iron-based phosphate binder for the treatment of elevated serum phosphorus levels, or hyperphosphatemia, in patients with end-stage renal disease (ESRD) on dialysis.

20 Sep 2011

Multispectral fluorescence imaging system can localize cancer cells during surgery

Ovarian cancer is one of the most frequent forms of cancer that affect women. As tumors can initially grow unchecked in the abdomen without causing any major symptoms, patients are usually diagnosed at an advanced stage and have to undergo surgery plus chemotherapy. During the operation, surgeons attempt to remove all tumor deposits as this leads to improved patient prognosis. To do this, however, they primarily have to rely on visual inspection and palpation - an enormous challenge especially in the case of small tumor nests or remaining tumor borders after the primary tumor excision.

20 Sep 2011

Scientists pioneer new combination treatment for prostate cancer

Scientists at Queen's University have pioneered a new combination treatment for prostate cancer. The treatment, which has been successful in phase one of trials, will now be tested for efficacy in a second phase.

20 Sep 2011

Cell News and Research

Niiki Pharma announces positive data from ongoing trial of novel anti-cancer agent NKP-1339

A code beyond DNA: Modified tRNA bases are characteristic of species

Vigorous exercise results in stronger bones, reduced diabetes risk and less visceral fat

New trick of tumors

Liposomes block HIV infection in early tests

Immune system uses zinc to destroy tuberculosis bacillus, E. coli

Walnuts improve inferential reasoning skills among students

Medication non-adherence interventions should be based on personal systems approach

Scientists discover how liver destroys immune T-cells

TJUH adopts new equipment from Roche Diagnostics for laboratory testing services

Combination of lunasin and oxaliplatin prevents colon cancer from metastasis

Scientists identify oldest known DNA regulatory region

Vitrolife obtains Chinese SFDA approval for aspiration needles and micropipettes

FoxM1 protein plays a critical role in development of medulloblastomas

UNC researchers reveal genetic underpinnings of Foxp3-expressing regulatory T cells

New UCSB technology can identify cancerous prostate cells

UNC researchers develop technique that can observe cellular intricacies of CF

Keryx completes enrollment in Zerenex Phase 3 long-term study for hyperphosphatemia

Multispectral fluorescence imaging system can localize cancer cells during surgery

Scientists pioneer new combination treatment for prostate cancer

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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