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New technique can detach sugars from carrier molecule, reattach them to drugs

The surface of cells and many biologically active molecules are studded with sugar structures that are not used to store energy, but rather are involved in communication, immunity and inflammation.

22 Aug 2011

Scientists discover key defense mechanism against C. difficile infection

Researchers have discovered a key mechanism used by intestinal cells to defend themselves against one of the world's most common hospital-acquired bacterial infections - a mechanism they think they can exploit to produce a therapy to protect against the effects of the antibiotic-resistant bacteria.

22 Aug 2011

Veteran status strongly linked with increased likelihood of extramarital sex, divorce

Veterans were significantly more likely to have ever engaged in extramarital sex and ever gotten divorced than people who were never in the military, according to new research to be presented at the 106th Annual Meeting of the American Sociological Association.

22 Aug 2011

Winter airway infections appear to trigger narcolepsy: Study

The onset of narcolepsy appears to follow seasonal patterns of H1N1 and other upper airway infections, according to a new study of patients in China that was led by Stanford University School of Medicine narcolepsy expert Emmanuel Mignot, MD.

22 Aug 2011

First computerized genome-scale model of cancer cell metabolism

Scientists are constantly on the hunt for treatments that can selectively target cancer cells, leaving other cells in our bodies unharmed.

22 Aug 2011

Disadvantaged, unhealthy mothers more likely to have sickly children

Disadvantaged, unhealthy mothers are much more likely to have sickly children than are disadvantaged moms who are relatively healthy—and this is not only due to genetics, suggests new research to be presented at the 106th Annual Meeting of the American Sociological Association.

22 Aug 2011

Scientists identify common cause of all forms of amyotrophic lateral sclerosis

The underlying disease process of amyotrophic lateral sclerosis (ALS and Lou Gehrig's disease), a fatal neurodegenerative disease that paralyzes its victims, has long eluded scientists and prevented development of effective therapies. Scientists weren't even sure all its forms actually converged into a common disease process.

22 Aug 2011

New findings on cancer stem cells

In cancer, tumors aren't uniform: they are more like complex societies, each with a unique balance of cancer cell types playing different roles. Understanding this "social structure" of tumors is critical for treatment decisions in the clinic because different cell types may be sensitive to different drugs. A common theory is that tumors are a hierarchical society, in which all cancer cells descend from special self-renewing cancer stem cells.

20 Aug 2011

New model for biomedical education

Leaders in biomedical education at Johns Hopkins University School of Medicine are calling for a radical new approach to post-graduate training in the life sciences to address significant challenges, including an avalanche of new discoveries in the last decade and the need to transcend traditional departmental boundaries to understand biological processes at multiple levels.

20 Aug 2011

Supermom myth could put working mothers at greater risk for depression

Working moms have lower rates of depression than their stay-at-home counterparts, but buying into the supermom myth could put working mothers at greater risk for depression, suggests new research to be presented at the 106th Annual Meeting of the American Sociological Association.

20 Aug 2011

Babies of mothers with higher pre-pregnancy BMI are fatter, finds study

Babies of mothers with a higher pre-pregnancy body mass index (BMI) are fatter and have more fat in their liver, a study published in September's issue of the journal Pediatric Research has found.

20 Aug 2011

NIH-supported project expands genetic research into clinical setting

Northwestern University Feinberg School of Medicine researchers have received a $762,000 grant from the National Institutes of Health (NIH) to tailor drug treatments to patients' genomic information.

20 Aug 2011

FDA approves Seattle Genetics ADCETRIS drug to treat Hodgkin lymphoma, ALCL

Seattle Genetics, Inc. today announced that the U.S. Food and Drug Administration has granted accelerated approval of ADCETRISTM for two indications: (1) the treatment of patients with Hodgkin lymphoma after failure of autologous stem cell transplant or after failure of at least two prior multi-agent chemotherapy regimens in patients who are not ASCT candidates, and (2) the treatment of patients with systemic anaplastic large cell lymphoma after failure of at least one prior multi-agent chemotherapy regimen.

20 Aug 2011

NIH approves BioTime's four GMP human embryonic stem cell lines

BioTime, Inc., a biotechnology company that develops and markets products in the field of regenerative medicine, today announced that four human embryonic stem (hES) cell lines: ESI-035, ESI-049, ESI-051 and ESI-053, developed by a BioTime subsidiary have been approved by the National Institutes of Health (NIH) for inclusion in the NIH Human Embryonic Stem Cell Registry.

20 Aug 2011

Seattle Genetics receives FDA approval for Adcetris to treat Hodgkin lymphoma, ALCL

The U.S. Food and Drug Administration today approved Adcetris to treat Hodgkin lymphoma and a rare lymphoma known as systemic anaplastic large cell lymphoma.

20 Aug 2011

Echocardiogram may not improve patients' survival rates after elective surgery

A new study has found no evidence that patients who had a heart ultrasound known as an echocardiogram before major surgery had improved survival rates one month or one year after their operation.

19 Aug 2011

Cerus to support ongoing development of INTERCEPT red cell system

Cerus Corporation announced today that it has received a $2.1 million award from the U.S. Department of Defense to support the advanced development of the company's technology for inactivating pathogens and leukocytes in red blood cells.

19 Aug 2011

Seven research teams across the U.S. to develop new drugs for nervous system disorders

The National Institutes of Health has made awards to investigators across the United States for an ambitious set of projects seeking to develop new drugs for disorders of the nervous system.

19 Aug 2011

Longer looks: Doctors advocating less care; addiction as a 'disease'

These physicians are not anti-medicine. They are not trying to save money on their copayments or deductibles. And they are not trying to rein in the nation's soaring health-care costs, which at $2.7 trillion account for fully one sixth of every dollar spent in the U.S. They are applying to their personal lives a message they have become increasingly vocal about in their roles as biomedical researchers and doctors: more health care often means worse health.

19 Aug 2011

Single-molecule imaging reveals how cells prepare to interact with biochemical signals

Researchers at Harvard Medical School have discovered that structural elements in the cell play a crucial role in organizing the motion of cell-surface receptors, proteins that enable cells to receive signals from other parts of the organism.

19 Aug 2011