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Stem cell treatments could repair the kidney defects associated with Alport syndrome

Several cell-based therapy approaches could provide new treatments for patients with Alport syndrome, reports an upcoming paper in the Journal of the American Society of Nephrology (JASN). "Our study opens up many considerations of how new therapies related to the use of stem cells can be devised for our kidney patients with chronic disease," comments Raghu Kalluri, MD, PhD (Harvard Medical School, Boston, MA).

19 Oct 2009

Immune-related proteins are potential drug targets for gastric inflammation and cancer

A research team from South Korea studied the complex reaction of gastric inflammation induced by Helicobacter pylori (H pylori) in a systematic manner using a protein interaction network. Their study will be published on September 28, 2009 in the World Journal of Gastroenterology.

19 Oct 2009

Researchers find the genetic mutation that is linked with changes in brain development

For decades, scientists have thought the faulty neural wiring that predisposes individuals to behavioral disorders like autism and psychiatric diseases like schizophrenia must occur during development. Even so, no one has ever shown that a risk gene for the disease actually disrupts brain development.

19 Oct 2009

New scientific journal from Elsevier

Elsevier, a world-leading publisher of scientific, technical and medical information products and services announced today the launch of a new peer-reviewed scientific journal, Spatial and Spatio-temporal Epidemiology (http://www.elsevier.com/locate/sste).

19 Oct 2009

Research study on cowpox virus

In the annals of medicine, Edward Jenner's 1796 vaccination of a young boy against smallpox, using fluid from cowpox blisters, remains a landmark case. In a new study, Kathryn Sykes, a researcher at Arizona State University's Biodesign Institute and her colleagues have taken a fresh look at cowpox.

19 Oct 2009

Rituxan's sBLA receives a Complete Response from the FDA

Genentech, Inc. a wholly-owned member of the Roche Group, and Biogen Idec announced today that the companies received a Complete Response from the U.S. Food and Drug Administration (FDA) for a supplemental Biologics License Application (sBLA) for Rituxan (rituximab) plus methotrexate (MTX) in patients with moderately-to-severely active rheumatoid arthritis (RA) who no longer respond to treatment with a disease modifying antirheumatic drug (DMARD), including MTX.

19 Oct 2009

Ethics in biomedical research: One-year grant from NIH to develop interactive educational software

Arkitek Studios and the Northwest Association for Biomedical Research (NWABR) have been awarded a $100,000 Phase I Small Business Innovation Research (SBIR) grant from the National Center for Research Resources, a component of the National Institutes of Health. This one-year grant, entitled ETHOS (Ethics Training Health Oriented Software), provides funding for development of interactive educational software that will underscore the critical role ethics plays in biomedical research.

19 Oct 2009

New chromosomal abnormality in acute lymphoblastic leukemia

Researchers identified a new chromosomal abnormality in acute lymphoblastic leukemia (ALL) that appears to work in concert with another mutation to give rise to cancer. This latest anomaly is particularly common in children with Down syndrome.

19 Oct 2009

DKC establishes link between genetic mutation affecting telomerase function and human disease

The human genetic disease dyskeratosis congenita (DKC) is an autosomal dominant disease that leads to abnormalities in tissues with a rapid cell turnover - the skin, nails, bone marrow, lungs and gut. Patients with DKC experience life-threatening symptoms. Bone marrow failure increases their risk of fatal infections and cancer. Many die before the age of 30 and management of the disease is limited to trying to treat its symptoms.

19 Oct 2009

Cardium Therapeutics reports positive findings from Excellarate Phase 1/2 clinical study

Cardium Therapeutics today announced the publication of positive findings from the open label multi-center Phase 1/2 clinical study of Excellarate(TM) (GAM501, Ad5PDGF-B / 2.6% collagen), its product candidate for the potential treatment of non-healing diabetic foot ulcers.

19 Oct 2009

DFG Research Centre to be funded for a further four-year period

The DFG Research Centre for Renewable Therapies at the Technical University of Dresden ("Renewable Therapies: From Cells to Tissues to Therapies - Engineering the Cellular Basis of Regeneration ", CRTD), following a very successful first funding period, is being extended and will be funded for a further four years.

19 Oct 2009

Novel HIV drug to be studied in cell cultures and patients

A $6 million, five-year federal grant to The Children's Hospital of Philadelphia Research Institute will enable researchers to investigate a novel approach in treating HIV infection---a unique class of drugs focused on developing therapies for psychological and neurological effects in AIDS.

19 Oct 2009

NCCN program on Discovery Health Channel profiles patients battling lung cancer

Lung cancer is the second most common cancer and leading cause of cancer-related deaths in both men and women. Although tobacco use is the strongest known risk factor for lung cancer, many people who never smoked also develop the disease.

19 Oct 2009

Clemson University receives a $9.3M NIH grant to establish a tissue regeneration center

Clemson University has received a $9.3 million, five-year National Institutes of Health (NIH) grant to establish a Center of Biomedical Research Excellence (COBRE) for Tissue Regeneration. Faculty from the Medical University of South Carolina and the University of South Carolina also will collaborate, providing expertise in medicine and developmental biology.

19 Oct 2009

Institute Curie Hospital in France adds another TomoTherapy radiation therapy system

TomoTherapy Incorporated announced today that the Institute Curie Hospital in France has purchased a second TomoTherapy® radiation therapy system, to support the increasing demand for intensity-modulated radiation therapy (IMRT). The Institute Curie Hospital has been treating cancer patients with TomoTherapy technology since March 2007, when it became the first hospital in France to adopt the technology.

19 Oct 2009

Mothers receiving HAART less likely to transmit HIV virus to their newborns through breastfeeding

Mothers receiving highly active antiretroviral therapy (HAART) to treat HIV-1 infection are less likely than untreated mothers to transmit the virus to their newborns through breastfeeding, according to a new study.

19 Oct 2009

Ruthenium and Osmium compounds show high levels of activity against ovarian cancer

Drugs made using unusual metals could form an effective treatment against colon and ovarian cancer, including cancerous cells that have developed immunity to other drugs, according to research at the University of Warwick and the University of Leeds.

19 Oct 2009

Research programme to develop immunological biomarkers for chronic inflammatory diseases

Persistent inflammation and the activation of the immune system is the key pathological mechanism affecting many long-term conditions, such as rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn's disease and is the predominant mechanism underlying organ transplant rejection.

19 Oct 2009

Research study provides supportive evidence for using ATR inhibitors in cancer therapy

A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tissue maintenance in mice.

19 Oct 2009

Gates Foundation to announce grants to promote agriculture at world food prize symposium

During a "keynote speech" Thursday at the World Food Prize Symposium in Des Moines, Iowa, Bill Gates, cofounder of the Bill & Melinda Gates Foundation, is expected to announce $120 million in grants "to promote dynamic, home-grown, sustainable agriculture in Africa and India,"

19 Oct 2009

Cell News and Research

Stem cell treatments could repair the kidney defects associated with Alport syndrome

Immune-related proteins are potential drug targets for gastric inflammation and cancer

Researchers find the genetic mutation that is linked with changes in brain development

New scientific journal from Elsevier

Research study on cowpox virus

Rituxan's sBLA receives a Complete Response from the FDA

Ethics in biomedical research: One-year grant from NIH to develop interactive educational software

New chromosomal abnormality in acute lymphoblastic leukemia

DKC establishes link between genetic mutation affecting telomerase function and human disease

Cardium Therapeutics reports positive findings from Excellarate Phase 1/2 clinical study

DFG Research Centre to be funded for a further four-year period

Novel HIV drug to be studied in cell cultures and patients

NCCN program on Discovery Health Channel profiles patients battling lung cancer

Clemson University receives a $9.3M NIH grant to establish a tissue regeneration center

Institute Curie Hospital in France adds another TomoTherapy radiation therapy system

Mothers receiving HAART less likely to transmit HIV virus to their newborns through breastfeeding

Ruthenium and Osmium compounds show high levels of activity against ovarian cancer

Research programme to develop immunological biomarkers for chronic inflammatory diseases

Research study provides supportive evidence for using ATR inhibitors in cancer therapy

Gates Foundation to announce grants to promote agriculture at world food prize symposium

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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