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Structure of receptor for hot chili pepper and pain revealed

You can now not only feel the spicy kick of a jalapeno pepper, you can also see it in full 3D, thanks to researchers at Baylor College of Medicine in Houston.

19 May 2008

Abnormal "editing" of gene messages may cause Lupus

Researchers at Wake Forest University have uncovered evidence that the abnormal "editing" of gene messages in a type of white blood cell may be behind the development of lupus. Scientists hope the finding will lead to earlier diagnosis, a way to monitor patients' response to therapy and possibly a new way to treat the disease.

19 May 2008

Minocycline may find new life as a stroke treatment

An old intravenous antibiotic may have new life as a stroke treatment, researchers say. Minocycline appears to reduce stroke damage in multiple ways - inhibiting white blood cells and enzymes that, at least acutely, can destroy brain tissue and blood vessels, respectively, says Dr. David Hess, chair of the Department of Neurology in the Medical College of Georgia School of Medicine.

19 May 2008

Radiofrequency ablation is an effective treatment for dysplasia in people with Barrett's esophagus

Interim results from a nationwide clinical trial led by a University of North Carolina at Chapel Hill researcher suggest that radiofrequency ablation is an effective treatment for dysplasia in people with Barrett's esophagus, a condition that can lead to deadly gastrointestinal cancer.

19 May 2008

Mapping of prostate cancer genes opens the door to new treatments

Genetic changes during the initiation and progression of prostate cancer have eluded scientists to date. Now for the first time researchers have identified a specific gene expression profile of prostate cancer stem cells, with important implications for future treatments.

19 May 2008

An improved gene therapy agent from University of Florida

Replacing one amino acid on the surface of a virus that shepherds corrective genes into cells could be the breakthrough scientists have needed to make gene therapy a more viable option for treating genetic diseases such as hemophilia, University of Florida researchers say.

19 May 2008

Reliable genetic tests could predict lung cancer recurrence

The goal of developing reliable genetic tests to guide lung cancer treatment has taken a step forward. Researchers at Columbia University recently evaluated the ability of five high-risk genetic profiles, or signatures, to predict the likelihood that cancer would recur in patients whose non-small cell lung cancer was caught early and surgically removed.

19 May 2008

Spectrum Pharmaceuticals to present data on Ortataxel in breast cancer at major oncology meeting

Spectrum Pharmaceuticals, Inc., will present Phase 2 data on ortataxel at the 44th American Society of Clinical Oncology (ASCO) Annual Meeting being held May 30 to June 3, 2008 at the McCormick Place Convention Center in Chicago, Illinois.

19 May 2008

NYT examines limited options for disabled children who reach age 18

The New York Times on Wednesday examined how as "medical advances have allowed patients who might have died as children to survive into adulthood, the patients are falling into a void in a health care system that has yet to develop institutions for the young and 'medically fragile.'"

19 May 2008

Nasal gel to fight superbug MRSA

British scientists are well on the way to developing a new drug to fight the 'superbug' Methicillin-resistant Staphylococcus aureus (MRSA).

19 May 2008

Cancer Research UK and AstraZeneca announce innovative deal for promising anti-cancer compound

Cancer Research UK and Cancer Research Technology (CRT) - the charity's development and commercialisation arm - today announced an innovative new arrangement to progress into clinical development a potential anti-cancer compound from AstraZeneca.

19 May 2008

Researchers discover 'reservoir' that allows HIV to remain infectious despite treatment

Researchers at Brigham Young University and the Johns Hopkins School of Medicine have discovered a human cell "reservoir," called follicular dendritic cells, that allows HIV to stay in an infectious state and not respond to antiretroviral drugs, the Deseret Morning News reports.

19 May 2008

deCODE discovers novel genetic links between pigmentation traits and risk of skin cancer

In two papers published today, deCODE scientists and academic colleagues from Europe and the U.S. expand upon the company's recent findings in the genetics of pigmentation traits in people of European descent, and demonstrate that certain of these common variants also confer risk of two types of skin cancer.

19 May 2008

New dimension discovered in body clock rhythm

Research on what makes the body clock tick has led Dr Michael Hastings of the MRC Laboratory of Molecular Biology in Cambridge to discover a new and unanticipated cog in the human body clock. A patent for the compound involved has been filed by MRC Technology. The results, published in Science, could lead to therapies for people whose sleep is disrupted by shift work or old age.

18 May 2008

DNA vaccines boosted by dendritic cells

The concept sounds ideal: vaccines made of DNA that could be taken in by other cells and give instructions for how to fight off different diseases. The reality, however, has fallen short. Although DNA vaccines have been around for about 15 years and shown lots of promise for HIV, SARS and influenza vaccines during preclinical testing in mice, researchers have yet to make them potent enough to be helpful in humans.

18 May 2008

Study implicates 350 gene regions in cancer development in the mouse

A large genetic study in mice has identified hundreds of genes involved in the development of cancer by examining the DNA of more than 500 lymphomas to find the cancer causing mutations.

15 May 2008

Discovery of 250 new genes potentially involved in leukemia

Researchers have found over 250 new genes that are potentially involved in the development of leukemia. The research was performed in close collaboration between the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (Amsterdam, The Netherlands) and the Wellcome Trust Institute (Cambridge, UK) and will be published in the Friday May 16th issue of the scientific journal Cell.

15 May 2008

Length of telomeres in blood cells tied to breast cancer survival rates

Researchers at Umea University in Sweden have shown that the length of telomeres in blood cells in newly diagnosed breast cancer patients is tied to survival rates. The study, published in the journal Cancer Research, was carried out by a research team headed by Professor Goran Roos at the Department of Medical Bioscience, Pathology.

15 May 2008

Australian scientists use gene technology to improve IVF treatment

Research by a team of Australian scientists promises to improve the fertility treatment in vitro fertilisation (IVF).

15 May 2008

First evidence of native dendritic cells in brain

In a finding that has the potential to change the way researchers think about the brain, scientists at Rockefeller University have found dendritic cells where they've never been seen before: among this organ's neurons and connective cells.

15 May 2008