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New pieces in the autism inheritance puzzle

Pieces in the complex autism inheritance puzzle are emerging in the latest study from a research team including geneticists from the University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia (CHOP). The study identified 27 different genetic regions where rare copy number variations - missing or extra copies of DNA segments - were found in the genes of children with autism spectrum disorders, but not in the healthy controls. The findings are published June 26 in the open-access journal PLoS Genetics.

30 Jun 2009

Hormone therapy may confer more aggressive properties to prostate tumours

Hormone therapy is often given to patients with advanced prostate cancer. While it is true that the treatment prevents growth of the tumour, it also changes its properties. Some of these changes may result in the tumour becoming more aggressive and more liable to form metastases. This is one of the conclusion of a thesis presented at the Sahlgrenska Academy, University of Gothenburg, Sweden.

10 Jun 2009

Research details function of key protein in cancer spread

Research led by David Worthylake, PhD, Assistant Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, may help lay the groundwork for the development of a compound to prevent the spread of cancer. The research will be published in the May 29, 2009 issue of the Journal of Biological Chemistry.

22 May 2009

Genes that influence brain cell connections linked to autism

In three studies, including the most comprehensive study of autism genetics to date, investigators funded in part by the National Institutes of Health have identified common and rare genetic factors that affect the risk of autism spectrum disorders.

30 Apr 2009

Discovery of gene region that may account for as many as 15 percent of autism cases

A research team has connected more of the intricate pieces of the autism puzzle, with two studies that identify genes with important contributions to the disorder.

30 Apr 2009

SARcode announces results of phase 1 trial of SAR 1118 ophthalmic solution in healthy adult subjects

SARcode Corporation announced today the results of its Phase 1 randomized, double-masked, placebo-controlled trial of the safety, tolerability, and pharmacokinetics of single- and multiple-escalating doses of SAR 1118 Ophthalmic Solution in healthy volunteers.

30 Mar 2009

Gene scan shows body's sleep cycle influences numerous physical functions

The pineal gland - integral to setting the body's sleep and wake cycles - may be involved in a broad range of bodily functions, according to a study by researchers at the National Institutes of Health and other institutions.

30 Mar 2009

Test successfully identifies arrhythmogenic right ventricular cardiomyopathy

11 Mar 2009

New test successfully identifies arrhythmogenic right ventricular cardiomyopathy

A study led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has demonstrated that a new immunohistochemical test is reliable in diagnosing a dangerous arrhythmic heart disease known as arrhythmogenic right ventricular cardiomyopathy (ARVC.) Reported in the March 12 issue of The New England Journal of Medicine ( NEJM ), the new findings offer the possibility of a highly sensitive and specific means of identifying this life- threatening condition at an early stage, when it can be treated with by implanting a cardiac defibrillator.

11 Mar 2009

Advances in nanotechnology point to next generation of prostheses

The futuristic technology of the Six Million Dollar Man - specifically a part metal and part flesh human being - won't be exclusive to Hollywood anymore.

29 Jan 2009

Discovery of first gender-linked susceptibility gene for late-onset Alzheimer's disease

In the Jan. 11 online edition of Nature Genetics, they report the results of their two-stage genome-wide association study of patients with Alzheimer's disease. The research showed that women who inherited two copies of a variant in the PCDH11X gene, found on the X chromosome, are at considerably greater risk of developing Alzheimer's disease.

12 Jan 2009

Anti-oestrogen drugs may promote more harmful cancer cell behaviour

The authors found that tamoxifen can promote an invasive phenotype in ER+ breast cancer cells under conditions of poor cell-cell contact, a previously unknown effect of this drug

3 Dec 2008

Systems biology and glycomics used to study human inflammatory diseases

An innovative systems biology approach to understanding the carbohydrate structures in cells is leading to new ways to understand how inflammatory illnesses and cardiovascular disease develop in humans. The work was described in two recent publications by University at Buffalo chemical engineers.

28 Oct 2008

Molecule provides new understanding of cause of colon cancer

Scientists investigating a molecule known to play a key role in causing colon cancer have made a series of ground-breaking discoveries that could have major implications for future treatment of the disease, responsible for 655,000 deaths worldwide per year. Their findings are published in the journal Cancer Research.

30 Sep 2008

Study reveals how blood flow force protects against atherosclerosis

Machines on cell surfaces, mechanical and lifeless as bed springs, protect blood vessels by responding to blood flow force, according to research published today in the Journal of Cell Biology. By sensing and reacting to force, such machines interfere with inflammatory pathways central to atherosclerosis, the cause of clogged arteries that lead to heart attack and stroke, the authors said. The next set of studies, already underway, seeks to "tweak" the process with the goal of designing a new class of therapies.

25 Aug 2008

Seven elevated biomarkers predict prostate cancer risk with 86.6 percent reliability

A simple blood test screening for a panel of biomarkers can accurately predict whether a patient who has had prostate cancer surgery will have a recurrence or spread of the disease.

26 Jun 2008

New details on how low blood flow promotes vascular disease

Researchers have found the first direct proof that a key protein drives the clogging of arteries in two ways, and that lowering levels of it opens them up, according to study results published in the June edition of the journal Circulation.

24 Jun 2008

Study provides direct proof on how key protein promotes vascular disease

23 Jun 2008

Embryonic pathway delivers stem cell traits

Studies of how cancer cells spread have led to a surprising discovery about the creation of cells with adult stem cell characteristics, offering potentially major implications for regenerative medicine and for cancer treatment.

25 May 2008

New prognostic markers for gastric cancer patients

In standard clinical settings, DNA microarrays are currently unsuitable for routine use. Prognostic classification on formalin-fixed paraffin-embedded tissues is required. In this study, we looked for new molecular markers for identifying the prognosis of gastric cancer patients.

20 May 2008