Cell Cycle News and Research

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Update on PALLAS triaI evaluating adjuvant palbociclib for early breast cancer

The Austrian Breast & Colorectal Cancer Study Group, Alliance Foundation Trials, the Breast International Group, PrECOG, LLC, the German Breast Group, and the NSABP Foundation today announced that the independent Data Monitoring Committee for the global Phase 3 early breast cancer PALbociclib CoLlaborative Adjuvant Study trial determined that the study is unlikely to show a statistically significant improvement in the primary endpoint of invasive disease-free survival following a preplanned interim analysis.

1 Jun 2020

Researchers identify genetic mechanisms that produce radioresistance in cancer cells

Cancer stem cells are a cell type that was previously little known. They are resistant to irradiation and prevent the effective treatment of many types of cancer. A research group from Innsbruck has now identified two genetic mechanisms that produce this radioresistance.

26 May 2020

Researchers identify determining factor in luminal cancer cells

The Translational Control of Cell Cycle and Differentiation Lab at IRB Barcelona, led by ICREA researcher Raúl Méndez, has published a study in the journal Science Advances that has identified a key factor in the development of luminal breast cancer.

18 May 2020

Roswell Park team proposes possible new strategy for treating pancreatic cancer

A possible new strategy for treating pancreatic cancer highlights the promise of collaboration between experts in both precision medicine and immunology.

18 May 2020

New study sheds light on the cause of stem cell mutations

Research from the University of Sheffield has given new insight into the cause of mutations in pluripotent stem cells and potential ways of stopping these mutations from occurring.

15 May 2020

SARS-CoV-2 binds heparan sulfate, preventing host cell infection

A new study published in May 2020 on the preprint server bioRxiv shows that the SARS-CoV-2 virus can bind to a sugar molecule called heparan sulfate (HS), thereby hindering its entry into the host cell.

12 May 2020

Researchers re-purpose cancer-fighting artificial antibodies for COVID-19

Researcher Paula Bates, John Trent, and Don Miller developed a therapeutic drug that could potentially block the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the COVID-19 pandemic. Their research was initially aimed at helping patients suffering from multiple types of cancer.

27 Apr 2020

Scientists find gene signature for poor response to standard therapy in rare uterine cancer

Women who don't survive a rare and aggressive uterine cancer called uterine serous carcinoma, have high expression of a group of 73 genes, a score scientists say can help identify these women and improve their outcome.

22 Apr 2020

Radiation therapy plays a crucial role in management of OPSCC

HPV-negative UM-SCC4 with and without transfection of HPV E6 oncoprotein, HPV-negative UPCI-SCC-089, and HPV-positive UPCI-SCC-099 cell lines were used in this study.

22 Apr 2020

Harnessing power of cancer gene could lead to first curative treatment for heart disease

Researchers trying to turn off a gene that allows cancers to spread have made a surprising U-turn. By making the gene overactive and functional in the hearts of mice, they have triggered heart cell regeneration.

15 Apr 2020

Potential cure for heart disease via cancer gene upregulation

Researchers have found that by switching on a gene that promotes the spread of cancers, they can enhance the regeneration of damaged heart muscle. The study results, published in April 2020 in the journal Nature Communication, could mark the beginning of curative therapy for heart disease.

14 Apr 2020

Voluntary exercise could help prevent liver cancer, study shows

Liver cancer is the fourth most common cause of cancer death worldwide and is growing rapidly due to the "diabesity pandemic."

14 Apr 2020

Combining Improved Ion Usage Efficiency with Data Independent Acquisition to Quantify Proteomes

In this interview, Dr. Ben Collins, Reader from the School of Biological Sciences, Queen’s University Belfast talks to News-Medical Life Sciences about his research and work into diaPASEF workflow.

From Bruker Life Sciences Mass Spectrometry 8 Apr 2020

Researchers find direct link between MCL1 protein and cell-cycle checkpoint protein

Human cells respond to stresses like DNA damage, metabolic imbalance and starvation by first trying to repair the problem.

5 Apr 2020

New study overturns ‘snapshot’ model of cell cycle accepted since 1974

Cells have a big decision: Should they replicate or sleep? Healthy cells can go either way. Cancer cells' replication switches are stuck in the 'on' position.

2 Apr 2020

Roscovitine enhances nuclear enrichment of traditionally cytoplasmic signaling molecules

Oncotarget Volume 11, Issue 12 reported that using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of c-Raf that drives differentiation/G0-arrest, the research team now observe that roscovitine enhanced nuclear enrichment of certain traditionally cytoplasmic signaling molecules and enhanced differentiation and cell cycle arrest.

26 Mar 2020

Scientists use artificial intelligence to create new proteins unseen in nature

Researchers have presented a artificial intelligence method for developing new proteins that have never been seen in nature.

17 Mar 2020

Trial of cancer drug OxaliTex promises lower toxicity and more robust action

Preclinical trials indicate that a drug candidate called OxaliTex can stop the growth of cancer cells completely. OxaliTex appears to be more potent than many other common chemotherapy drugs, with less toxicity and less rapidly counteracted by mechanisms of drug resistance. The study was reported in the journal Proceedings of the National Academy of Sciences in March 2020.

16 Mar 2020

Study shows how cellular filament helps neural stem cells clear damaged, clumped proteins

New research by University of Wisconsin-Madison scientists reveals how a cellular filament helps neural stem cells clear damaged and clumped proteins, an important step in eventually producing new neurons.

28 Feb 2020

New study expands the knowledge on tumor-suppressor role of HERC proteins

The RAF protein could be a therapeutical target to treat the tumor growth in regulated pathways by the p38 protein, according to a new study published in the journal Scientific Reports by a team of experts of the Faculty of Medicine and Health Sciences of the University of Barcelona and the Bellvitge Institute for Biomedical Research.

20 Feb 2020