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Clinical trial of a combination treatment shows great promise for patients with glioblastoma

A new international study published in Nature Medicine and presented as a late-breaking abstract at the American Association of Neurological Surgeons annual conference, shows great promise for patients with glioblastoma.

15 May 2023

Combination approach is safe, improves survival outcomes in a subset of glioblastoma patients

Intratumoral delivery of an engineered oncolytic virus (DNX-2401) targeting glioblastoma (GBM) cells combined with subsequent immunotherapy was safe and improved survival outcomes in a subset of patients with recurrent GBM, according to results from a multi-institutional Phase I/II clinical trial co-led by researchers at The University of Texas MD Anderson Cancer Center and the University of Toronto.

15 May 2023

Brain cancer cells use mitochondria from the central nervous system to grow into aggressive tumors

Glioblastoma cancer cells use mitochondria from the central nervous system to grow and form more aggressive tumors, according to new Cleveland Clinic-led findings published in Nature Cancer.

11 May 2023

Study explores the role of dynamin protein DYN-1 in regenerative axonal fusion

A study explores the role of the dynamin protein DYN-1 in axonal fusion. The axon is a long, thin protrusion of nerve cells that carries electrical impulses.

9 May 2023

Novel fluorescent probe reveals constant conversion rate of endolysosomes

Collaborative research at the University of Cincinnati has developed a new probe to better study cells that has already led to new knowledge about certain cellular processes.

9 May 2023

NIH researchers identify new genetic risk factors for two types of non-Alzheimer's dementia

Scientists at the National Institutes of Health have identified new genetic risk factors for two types of non-Alzheimer's dementia.

8 May 2023

Study sheds new light on the role of somatic mutations in temporal lobe epilepsy

Epilepsy affects approximately 1-in-26 people and the most common form, known as temporal lobe epilepsy (TLE), often cannot be adequately treated with anti-seizure medications.

2 May 2023

Mechanism to protect the liver from destruction in case of obesity revealed

Scientists from the Immanuel Kant Baltic Federal University found out that blocking of receptor gp130 on the surface of liver cells helps to protect this organ from destruction in case of obesity.

27 Apr 2023

Study sheds light on immune factors responsible for contrasting SARS-CoV-2 outcomes in humans and white-tailed deer

Researchers explored the response of respiratory epithelial cells in deers to SARS-CoV-2.

27 Apr 2023

Study finds biomarker pattern in children with COVID 19-linked multisystem inflammatory syndrome

Children with multisystem inflammatory syndrome (MIS-C) — a rare condition linked with the virus that causes COVID-19 — have biochemical indicators of cell injury and cell death that are distinct from other children with COVID-19, according to a study funded by the National Institutes of Health.

25 Apr 2023

Research findings could help inform more effective therapies for AML

Acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes a large number of abnormal blood cells. It is the most common type of acute leukemia in adults.

24 Apr 2023

Mitophagy helps blood cancer cells to evade the killing effects of BH3 mimetic drug

Despite the promise of new medications that promote cancer cell death in people with acute myeloid leukemia, leukemic cells often adopt features that let them evade the drugs' effects within a year.

24 Apr 2023

Study uncovers a protein-protein interaction that contributes to Parkinson's disease

In a study published in Nature Communications, a team led by Krembil Brain Institute Senior Scientists, Drs. Lorraine Kalia and Suneil Kalia, and University of Toronto (U of T) Professor, Dr. Philip M. Kim, identified a protein-protein interaction that contributes to Parkinson's disease.

20 Apr 2023

Sex-specific differences in the risk and resilience for Alzheimer's disease

Two-thirds of people living with Alzheimer's disease in the United States are women, according to the Alzheimer's Association's 2019 Alzheimer's Disease Facts & Figures report.

19 Apr 2023

Novel imaging method shows link between iron redox and Alzheimer’s disease

There is a growing body of evidence that iron in the brain may play a role in Alzheimer's disease. Lending weight to that idea, a new imaging probe has for the first time shown that in the same regions of the brain where the amyloid beta plaques associated with Alzheimer's occur, there is also an increase in iron redox, meaning the iron in these regions is more reactive in the presence of oxygen.

19 Apr 2023

Edible mushrooms: the role of antioxidant compounds as potential candidates for neurodegenerative disease prevention and treatment

Researchers evaluated whether edible mushrooms aid in preventing neurodegenerative diseases.

18 Apr 2023

Researchers show how the EBV virus exploits genomic weaknesses to cause cancer

The Epstein-Barr virus (EBV) is easily spread through bodily fluids, primarily saliva, such as kissing, shared drinks or using the same eating utensils.

13 Apr 2023

Unexpected discovery could inspire new strategies for preventing liver disease and cancer

Liver cancer is the third leading cause of cancer death and the sixth most common cancer type worldwide.

12 Apr 2023

Novel optical imaging approach provides four-dimensional view of cell secretions

Cell secretions like proteins, antibodies, and neurotransmitters play an essential role in immune response, metabolism, and communication between cells.

11 Apr 2023

The Parkinson's Pandemic: from the importance of early diagnosis to digital solutions

News Medical spoke to Michele Hu, Consultant Neurologist at Oxford University Hospitals and Professor of Clinical Neuroscience at the Nuffield Department of Clinical Neurosciences, University of Oxford, about prodromal Parkinson's and what the future looks like for this neurological disease.