DNA Replication News and Research

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DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "semiconservative" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.

New molecular rulers for super-resolution microscopy: A breakthrough in biological imaging

Latest super-resolution microscopy methods now achieve an optical resolution in the range of a few nanometers.

1 Dec 2023

Genome haplarithmisis sheds light on complex genetic landscape of miscarriages

A new study published in Nature Medicine reports on a chromosomal analysis of over 1,700 spontaneous early miscarriages.

27 Nov 2023

Study sheds light on origins of breast cancer in people with BRCA2 mutations

A pioneering study led by Professor Ashok Venkitaraman from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore and Dr Mona Shehata from the University of Cambridge (UK) has uncovered vital insights into the distinct effects of BRCA2 mutations on breast tissue cells, shedding light on early breast cancer development in people with BRCA2 mutations.

1 Nov 2023

Study suggests a potential strategy to combat aggressive brain tumors

A new study has unraveled a crucial link between how cancer cells cope with replication stress and the role of Taurine Upregulated Gene 1 (TUG1). By targeting TUG1 with a drug, the researchers were able to control brain tumor growth in mice, suggesting a potential strategy to combat aggressive brain tumors such as glioblastomas.

12 Oct 2023

Study reveals how DNA damage caused by chromosomal instability increases cancer invasiveness

Chromosomal instability is a phenomenon characterized by rapid changes in the number and structure of chromosomes during cell division.

28 Sep 2023

Exercise boosts immune defense in Lynch syndrome patients

Aerobic exercise, specifically cycling, shows promise in reducing inflammation and boosting immune responses in the colonic tissue of Lynch syndrome patients, a group at high risk for colorectal cancer. The study suggests that regular exercise may offer a preventive approach for this patient population, though further randomized trials are needed.

24 Sep 2023

Groundbreaking discovery reveals how brain proteins can help alleviate DNA replication stress

A team of researchers from the Department of Biological Sciences at UNIST has achieved a significant breakthrough in understanding how brain proteins can help alleviate complications arising from DNA replication stress.

12 Sep 2023

Researchers unravel structure of MCM8/9 enzyme linked to infertility and cancer

Scientific research requires patience. The rewards are not always immediate, and the technology needed does not always exist. Michael A. Trakselis, Ph.D., professor and director of graduate affairs for the Department of Chemistry and Biochemistry at Baylor University, understands this.

29 Aug 2023

Researchers find link between topography of the genome and presence of cancer mutations

Researchers at the University of California San Diego have uncovered a connection between the topography of the human genome and the presence of mutations in human cancer.

24 Aug 2023

New PCNA inhibitor AOH1996 shows selective cancer cell killings and tumor suppression potential

Study described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells.

4 Aug 2023

Phase 1 clinical trial underway to test City of Hope-developed cancer treatment

Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, today published a new study explaining how they took a protein once thought to be too challenging for targeted therapy, proliferating cell nuclear antigen (PCNA), and developed a targeted chemotherapy that appears to annihilate all solid tumors in preclinical research.

1 Aug 2023

Study sheds light on how viruses override host cell's DNA replication machinery

University of Pittsburgh researchers have shown for the first time how Merkel cell polyomavirus (MCV), which causes an aggressive skin cancer called Merkel cell carcinoma, initiates DNA replication in host cells.

17 Jul 2023

Retrotransposons hijack cell's dna repair machinery to form circular DNA

Like its viral cousins, a somewhat parasitic DNA sequence called a retrotransposon has been found borrowing the cell's own machinery to achieve its goals.

12 Jul 2023

Cyanotriazole compounds can selectively and rapidly kill trypanosome parasites, study shows

Cyanotriazole compounds are fast-acting topoisomerase II poisons that can selectively and rapidly kill trypanosome parasites that cause Chagas disease and African sleeping sickness, according to a new study.

29 Jun 2023

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex."

13 Jun 2023

Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Melatonin, a hormone derived from the pineal gland, has diverse effects on cellular processes. This review explores its potential role as an epigenetic regulator, particularly in modulating DNA methylation, and suggests its use in combination therapy as a novel anticancer strategy.

30 May 2023

DNA Replication News and Research

Further Reading

New molecular rulers for super-resolution microscopy: A breakthrough in biological imaging

Genome haplarithmisis sheds light on complex genetic landscape of miscarriages

Study sheds light on origins of breast cancer in people with BRCA2 mutations

Study suggests a potential strategy to combat aggressive brain tumors

Study reveals how DNA damage caused by chromosomal instability increases cancer invasiveness

Exercise boosts immune defense in Lynch syndrome patients

Groundbreaking discovery reveals how brain proteins can help alleviate DNA replication stress

Researchers unravel structure of MCM8/9 enzyme linked to infertility and cancer

Researchers find link between topography of the genome and presence of cancer mutations

New PCNA inhibitor AOH1996 shows selective cancer cell killings and tumor suppression potential

Phase 1 clinical trial underway to test City of Hope-developed cancer treatment

Study sheds light on how viruses override host cell's DNA replication machinery

Retrotransposons hijack cell's dna repair machinery to form circular DNA

Cyanotriazole compounds can selectively and rapidly kill trypanosome parasites, study shows

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

Unlocking the potential of melatonin: A promising epigenetic weapon against cancer

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

CRISPR-Cas9 system can help reduce adenovirus replication in human cells

A downstream pathway critical for lymphoma development discovered

What is currently known about the mechanisms by which DNA tumor viruses evade uracil-mediated antiviral immunity?

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