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Targeting O-GlcNAcase enzyme with inhibitors might treat Alzheimer's

Slowing or preventing the development of Alzheimer's disease, a fatal brain condition expected to hit one in 85 people globally by 2050, may be as simple as ensuring a brain protein's sugar levels are maintained.

29 Feb 2012

Tiny molecule might help protect pancreas from cancer

A tiny molecule might help protect the pancreas from deadly disease and cancer. Tackling a mysterious process: There is a feeling that neglected cancers need more research and Pancreatic cancer is one of the least studied. Today, the survival rate is 3% for five years. Professor Petersen, at the School of Biosciences at Cardiff University, hopes his team's research can change that.

29 Feb 2012

Study identifies how chemo drug combination kills pancreatic cancer cells

Cancer Research UK scientists have discovered how a combination of two chemotherapy drugs - already showing promise in clinical trials - destroys pancreatic cancer cells, according to research published in Cancer Discovery.

29 Feb 2012

FDA grants orphan drug designation to Ultragenyx UX003 for treatment of MPS 7

Ultragenyx Pharmaceutical Inc., a biotechnology company focused on developing treatments for rare and ultra-rare genetic disorders, today announced that the FDA Office of Orphan Products Development has granted orphan drug designation for UX003 for the treatment of MPS 7.

28 Feb 2012

Insights into how fructose may contribute to development of obesity, diabetes

A group of scientists from across the world have come together in a just-published study that provides new insights into how fructose causes obesity and metabolic syndrome, more commonly known as diabetes.

28 Feb 2012

Scientists demonstrate how immortal flatworm overcomes aging process

Researchers from The University of Nottingham have demonstrated how a species of flatworm overcomes the ageing process to be potentially immortal.

28 Feb 2012

EMBL-EBI launches Enzyme Portal

The European Molecular Biology Laboratory's European Bioinformatics Institute has launched the Enzyme Portal, a freely available resource for people who are interested in the biology of enzymes and proteins with enzymatic activity.

28 Feb 2012

Chemically altered osteoporosis drug may fight malaria

A chemically altered osteoporosis drug may be useful in fighting malaria, researchers report in a new study. Unlike similar compounds tested against other parasitic protozoa, the drug readily crosses into the red blood cells of malaria-infected mice and kills the malaria parasite. The drug works at very low concentrations with no observed toxicity to the mouse.

27 Feb 2012

New RNA interference method holds promise for cancer, other diseases

For the past decade, scientists have been pursuing cancer treatments based on RNA interference - a phenomenon that offers a way to shut off malfunctioning genes with short snippets of RNA. However, one huge challenge remains: finding a way to efficiently deliver the RNA.

27 Feb 2012

BioConnections, Yissum to commercialize kits that detect MDR and XDR infections

Yissum, the research and development company of the Hebrew University of Jerusalem, had signed a licensing agreement with BioConnections, a UK based microbiology company, for the commercialization of kits that enables immediate detection of all multidrug resistant (MDR) and of any extremely drug resistant (XDR) infections.

27 Feb 2012

GSK, Angiochem to develop and commercialize LSD treatments

Angiochem announced today a global collaboration with GlaxoSmithKline (GSK) to discover, develop and commercialize treatments for lysosomal storage diseases.

27 Feb 2012

New method can predict whether Tylenol-poisoning patients need liver transplant

University of Utah mathematicians developed a set of calculus equations to make it easier for doctors to save Tylenol overdose patients by quickly estimating how much painkiller they took, when they consumed it and whether they will require a liver transplant to survive.

27 Feb 2012

Study finds genetic variants that elevate risk for skin lesions in people exposed to arsenic

One of the first large-scale genomic studies conducted in a developing country has discovered genetic variants that elevate the risk for skin lesions in people chronically exposed to arsenic. Genetic changes found near the enzyme for metabolizing the chemical into a less toxic form can significantly increase an individual's risk for developing arsenic-related disease.

26 Feb 2012

Rosemary aroma may improve cognitive performance

Hailed since ancient times for its medicinal properties, we still have a lot to learn about the effects of rosemary. Now researchers writing in Therapeutic Advances in Psychopharmacology, published by SAGE, have shown for the first time that blood levels of a rosemary oil component correlate with improved cognitive performance.

26 Feb 2012

Seven scientists aim to make strides in predicting and preventing preterm birth

With the help of funding from the March of Dimes, researchers from five states and Canada are seeking answers to questions such as how cellular-level processes that control uterine muscles may affect preterm labor, the causes of preeclampsia, and how air pollution may affect pregnancy and preterm birth - all with the goal of preventing preterm birth so more babies will get a healthy start in life.

24 Feb 2012

Fetus protecting enzyme also prevents autoimmune diseases

Cells that die naturally generate a lot of internal debris that can trigger the immune system to attack the body, leading to diseases such as lupus.

24 Feb 2012

Cigarette smoke exposure results in allograft rejection

A new study published in the American Journal of Transplantation reveals that cigarette smoke exposure, in a cause-effect manner, results in graft rejection that would have been prevented by certain drug treatments.

24 Feb 2012

Scientists identify promising strategy for HIV vaccine design

HIV has eluded vaccine-makers for thirty years, in part due to the virus' extreme ability to mutate. Physical scientists and clinical virologists from the Massachusetts Institute of Technology (MIT) and the Ragon Institute in Cambridge, Mass., have identified a promising strategy for vaccine design using a mathematical technique that has also been used in problems related to quantum physics, as well as in analyses of stock market price fluctuations and studies of enzyme sequences.

24 Feb 2012

More toxic aldehydes found in reheated sunflower and linseed oil

Researchers from the University of the Basque Country (UPV/EHU, Spain) have been the first to discover the presence of certain aldehydes in food, which are believed to be related to some neurodegenerative diseases and some types of cancer. These toxic compounds can be found in some oils, such as sunflower oil, when heated at a suitable temperature for frying.

23 Feb 2012

Insight into relationship between two types of suppressors in cancerous tumors

The University of Kentucky has announced that Dr. Daret St. Clair, the James Graham Brown Endowed Chair and professor of toxicology, has published the first comprehensive study that provides insight into the relationship between two types of suppressors in cancerous tumors. The results will enhance the understanding of transcriptional mechanisms in carcinogenesis.

23 Feb 2012