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New brain atlas reveals hidden cell vulnerabilities in Alzheimer's

Researchers created a detailed transcriptomic atlas of six brain regions, revealing cell-type-specific and region-specific vulnerabilities in Alzheimer's disease and highlighting astrocyte genes linked to cognitive resilience.

25 Jul 2024

Kaempferol's promise in fighting triple-negative breast cancer

Review highlights kaempferol's potential in treating triple-negative breast cancer through various anticancer mechanisms and improving chemotherapeutic efficacy.

24 Jul 2024

Challenging antibiotic resistance with dual-action macrolones

A new antibiotic that works by disrupting two different cellular targets would make it 100 million times more difficult for bacteria to evolve resistance, according to new research from the University of Illinois Chicago.

24 Jul 2024

Ohio State leads multi-million dollar research on long COVID solutions

A 2022 study suggesting that blocking a single molecule could protect against severe illness in COVID-19 has led to a $15 million federal grant supporting a comprehensive effort to learn more – with finding a solution to long COVID at the center of the new research.

23 Jul 2024

New study sheds light on irregular heartbeat risk

Two new, basic animal research studies shed light on alcohol consumption and the heart. The first study may help explain why binge drinking sometimes causes an irregular heartbeat and a possible way to prevent it. The second study investigated why alcohol may have a negative impact on heart function in women taking estrogen replacement therapy.

23 Jul 2024

Understanding the new coronavirus mutant strain KP.3.1.1

Researchers in Japan evaluated the SARS-CoV-2 KP.3.1.1 variant, finding it has higher transmissibility and immune evasion compared to previous variants, posing new challenges for public health measures.

22 Jul 2024

Multi-signal processing guide RNAs: A new frontier in gene regulation

Guides typically assist tourists with directions, but the experience could be greatly enhanced if they offered personalized services tailored to individual interests.

22 Jul 2024

UH research identifies key mechanisms of skeletal muscle regeneration

Newly published research from the University of Houston College of Pharmacy identifies key mechanisms of skeletal muscle regeneration and growth of muscles following resistance exercise.

22 Jul 2024

Long-term immune changes persist in unvaccinated COVID-19 patients

Study reveals that unvaccinated individuals experience significant long-term changes in immune parameters up to ten months post-COVID-19 infection, with a shift towards a Th2 cytokine profile.

21 Jul 2024

Concussions in retired rugby players linked to higher neurodegenerative disease biomarkers

A study in the International Journal of Molecular Sciences reveals that retired rugby players with a history of concussions exhibit significant differences in biomarkers associated with neurodegenerative diseases compared to non-contact sports participants.

21 Jul 2024

High mutation count in new COVID-19 variants does not increase immune evasion, study finds

New research from UNC Charlotte's Center for Computational Intelligence to Predict Health and Environmental Risks (CIPHER) has found that the two recent and prevalent strains of the virus that cause COVID-19, SARS-CoV-2 variants BA.2.86 and JN.1, are not significantly better than their predecessor Omicron at evading immune responses and causing infections despite having a high number of mutations compared to Omicron.

19 Jul 2024

New insights into modified nucleoside synthesis

The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved in maintaining and regulating the protein synthesis system.

19 Jul 2024

New drugs show promise in shrinking breast cancer brain metastases

Researchers from Drexel's College of Medicine have identified new drugs that show early success in shrinking breast cancer tumors that have metastasized in the brain.

18 Jul 2024

Porcine study reveals meurotoxic and pro-inflammatory effects of microplastics on enteric nervous system

Researchers investigates the effects of polyethylene terephthalate microplastics on the neuronal population in the porcine jejunum.

18 Jul 2024

Researchers find a special group of "first responder" cells crucial for triggering blood sugar response

How does our body control blood sugar so precisely? An international research team led by scientists from the Paul Langerhans Institute Dresden (PLID) of the German Center for Diabetes Research brought us a step closer to the answer.

17 Jul 2024

New approaches for repairing the function of mutated proteins that cause stroke

Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a rare, severe, and deadly genetic disorder characterized by damage to small blood vessels in the brain and which triggers strokes.

16 Jul 2024

Mitochondrially-targeted antioxidants could reduce SARS-CoV-2 effects across multiple organs

Building upon groundbreaking research demonstrating how the SARS-CoV-2 virus disrupts mitochondrial function in multiple organs, researchers from Children's Hospital of Philadelphia (CHOP) demonstrated that mitochondrially-targeted antioxidants could reduce the effects of the virus while avoiding viral gene mutation resistance, a strategy that may be useful for treating other viruses.

15 Jul 2024