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Celacade shown to reduce risk of death and hospitalization in patients with advanced chronic heart failure

Vasogen has announced that comprehensive results from the Company's phase II trial of Celacade (immune modulation therapy) in advanced chronic heart failure patients were published in the September 15 issue of the Journal of the American College of Cardiology (JACC).

16 Sep 2004

Drug combo may have a greater impact on cancer development

Cancer researchers have long suggested that new targeted drugs may work best when paired with other therapies. In a new study published today in Cancer Research, scientists have taken some of the first steps to demonstrate this synergy in mouse and cell line models.

16 Sep 2004

First molecular-scale images of DNA binding to an adenovirus enzyme

The images, which appear on the cover of the October 2004 issue of Molecular and Cellular Proteomics, show how binding to DNA may stimulate the enzyme and are already being used to design new antiviral drugs to block this interaction.

14 Sep 2004

Grant to study genetics and drug interaction

A University of Minnesota researcher received a nearly $1 million grant from the National Institutes of Health (NIH) to study how genetic differences affect whether people will experience dangerous drug interactions and how to adjust medications to avoid those interactions.

10 Sep 2004

Disruption of protein folding causes neurodegeneration, mental retardation

Excess accumulation in brain cells of a fat molecule called GM1-ganglioside (GM1) disrupts the folding of newly assembled proteins into their proper shapes, triggering nerve degeneration and mental retardation in children.

10 Sep 2004

Chemical pathways of serotonin in the nervous system pave way for future pharmaceutical treatments for depression

From mollusks to mammals, newly discovered chemical pathways of serotonin in the nervous system are paving a path toward future pharmaceutical treatments for depression and other disorders.

10 Sep 2004

Ramipril reduces rate of sudden cardiac death and nonfatal cardiac arrest by 21 percent

Ramipril, a high blood pressure and heart failure drug, can reduce the rate of sudden cardiac death and nonfatal cardiac arrest by 21 percent in people at high risk for heart attack or stroke, according to a study reported in Circulation: Journal of the American Heart Association.

7 Sep 2004

Researchers have successfully produced small quantities of a new vaccine for anthrax using Bacillus bacteria

Tiny types of soil bugs already make many of the products we use in washing detergents, foods, and waste treatment, but scientists now hope that similar bacteria will also make the vaccines and drugs of the future

7 Sep 2004

New way of killing dangerous bacteria like the ones which cause anthrax and pneumonia

The new bug-smashing technique uses the bacteria’s own natural enemies, tiny viruses called bacteriophages (or phages), which can infect bacterial cells. The phages make thousands of copies of themselves inside infected bacteria, but then need to dissolve the bacteria’s cell wall to get out and infect other bacterial cells.

7 Sep 2004

Generic tritherapy can be used as a basic treatment for AIDS

A clinical trial, conducted in Cameroon by IRD researchers working with other organizations and supported by the ANRS, has demonstrated that one of the most common combinations currently deployed in Africa, using nevirapine, stavudine and lamivudine, satisfies these criteria.

5 Sep 2004

University of Nottingham research developments could mean new drugs will reach cancer patients more quickly

A £3 million grant and the establishment of a specialized business unit that will help new treatments reach cancer patients more quickly, have underlined The University of Nottingham’s place at the forefront of cancer drug development.

2 Sep 2004

Broccoli, cauliflower and cabbage effective in disrupting late stages of cell growth in breast cancer

A well known anti-cancer agent in certain vegetables has just had its reputation enhanced. The compound, in broccoli and other cruciferous vegetables, has been found to be effective in disrupting late stages of cell growth in breast cancer.

1 Sep 2004

Flaw in DNA helps explain cancers and aging

Their finding explains how oxidative DNA damage - a process long believed to underlie cancers and aging - can create permanent genetic damage.

30 Aug 2004

Surgery for angina in the elderly provides long-term mortality

Elderly people who undergo surgery or angioplasty to treat chest pain fare just as well long-term as those treated with medication, researchers report in Circulation: Journal of the American Heart Association.

30 Aug 2004

Common enzyme acts as a natural brake to prevent potentially deadly runaway inflammation

An enzyme found in nearly all animal and human cells acts as a natural brake to prevent potentially deadly runaway inflammation, UCSF scientists have discovered.

30 Aug 2004

Streptococcal bacteria disrupts blood clotting to infect humans

University of Michigan researchers have captured a glimpse of the endless arms race between infectious agents and the human immune system in a bacterium that uses a mimic of a human blood-clotting enzyme to advance its infection.

27 Aug 2004

Emergence of drug resistant influenza viruses more common than previously thought

Results of a small study from Japan in this week’s issue of THE LANCET suggest that the emergence of influenza viruses which are resistant to a widely used influenza drug may be more common than previously thought.

26 Aug 2004

Researchers look to make more effective drug treatments for tuberculosis

Tuberculosis isn’t yet making a major comeback in the U.S. but one- third of the world’s population is infected with the disease, and it poses a major danger to health worldwide.

26 Aug 2004

Compounds break bonds holding dangerous pollutants together

Everything from the manufacture of new materials to the creation of modern medications relies on chemicals known as metal-based catalysts. Catalysts pack a double punch: Even as they greatly increase the rate of chemical processes, they regenerate so they can be used again.

25 Aug 2004

High-resolution images reveal the molecular rearrangements that rotavirus uses to break into cells

High-resolution images constructed by researchers at Children's Hospital Boston and Harvard Medical School reveal the molecular rearrangements that rotavirus – the most common cause of severe, dehydrating diarrhea and vomiting in children worldwide – uses to break into cells.

25 Aug 2004

Enzyme News and Research

Celacade shown to reduce risk of death and hospitalization in patients with advanced chronic heart failure

Drug combo may have a greater impact on cancer development

First molecular-scale images of DNA binding to an adenovirus enzyme

Grant to study genetics and drug interaction

Disruption of protein folding causes neurodegeneration, mental retardation

Chemical pathways of serotonin in the nervous system pave way for future pharmaceutical treatments for depression

Ramipril reduces rate of sudden cardiac death and nonfatal cardiac arrest by 21 percent

Researchers have successfully produced small quantities of a new vaccine for anthrax using Bacillus bacteria

New way of killing dangerous bacteria like the ones which cause anthrax and pneumonia

Generic tritherapy can be used as a basic treatment for AIDS

University of Nottingham research developments could mean new drugs will reach cancer patients more quickly

Broccoli, cauliflower and cabbage effective in disrupting late stages of cell growth in breast cancer

Flaw in DNA helps explain cancers and aging

Surgery for angina in the elderly provides long-term mortality

Common enzyme acts as a natural brake to prevent potentially deadly runaway inflammation

Streptococcal bacteria disrupts blood clotting to infect humans

Emergence of drug resistant influenza viruses more common than previously thought

Researchers look to make more effective drug treatments for tuberculosis

Compounds break bonds holding dangerous pollutants together

High-resolution images reveal the molecular rearrangements that rotavirus uses to break into cells

Measuring Drug-Target Residence Times with Biochemical Assays eBook

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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