Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Germ cell removal may promote longevity

The gonad is well known to be important for reproduction but also affects animal life span. Removal of germ cells - the sperm and egg producing cells - increases longevity of the roundworm Caenorhabditis elegans. However, the underlying molecular mechanisms were a mystery. Now scientists at the Cologne-based Max Planck Institute for Biology of Ageing, have discovered that germ cell removal flips a "molecular switch" that extends the life span by using components of a "developmental clock".

18 Dec 2012

Study investigates muscle weakness in mouse model of Down syndrome

It is well known that people with Down syndrome (DS) suffer from marked muscle weakness. Even the simple tasks of independent living, such as getting out of a chair or climbing a flight of stairs, can become major obstacles. This can reduce the quality of life for those with DS and lead to a loss of independence. Now, a new study sheds light on some of the suspected causes of muscle weakness.

18 Dec 2012

Human nociception genes mapped out

Researchers have uncovered a “network map” of genes that are involved in pain perception, which they say may help identify new analgesic drugs.

17 Dec 2012

Paternal exposure to cocaine can impair gene expression and behavior in their offspring

Research from the Perelman School of Medicine at the University of Pennsylvania and Massachusetts General Hospital (MGH) reveals that sons of male rats exposed to cocaine are resistant to the rewarding effects of the drug, suggesting that cocaine-induced changes in physiology are passed down from father to son.

17 Dec 2012

Fluidigm, GIS announce establishment of first single-cell genomics research center in Asia

The Genome Institute of Singapore (GIS), an institute under the umbrella of the Agency for Science, Technology and Research, and Fluidigm Corporation today announced the establishment of the first research center in Asia exclusively dedicated to accelerating the understanding of how individual cells work, and how diagnosis and treatment might be enhanced through insight derived from single cells.

15 Dec 2012

National Cheng Kung University kicks off 23rd International Conference on Genome Informatics

National Cheng Kung University kicked off GIW 2012 -- the 23rd International Conference on Genome Informatics -- at International Conference Hall Dec. 12, attracting more than 140 scholars from 10 countries including Japan, Korea, China, Singapore, Canada, America, Germany, and Australia.

14 Dec 2012

Administration of N2O + ISO appears to have negative effect on fetal development

An anesthetic regimen typically used during surgery on pregnant mothers appears to have a negative effect on the development of the fetus, according to a new study on mice conducted by neurobiologists from the National Center for Toxicological Research, in Arizona.

14 Dec 2012

TSEC strategy can benefit postmenopausal women

Investigators at Wake Forest Baptist Medical Center have concluded research on a new postmenopausal hormone therapy that shows promise as an effective treatment for menopausal symptoms and the prevention of osteoporosis without increasing the risk for heart disease or breast cancer.

13 Dec 2012

Study focuses on nontraditional lifestyle of Retinoblastoma tumor suppressor proteins

Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave.

13 Dec 2012

New diagnostic assay for screening ALK fusions in non-small cell lung carcinoma

Approximately one in 20 patients with non-small cell lung carcinoma (NSCLC) has chromosomal aberrations targeting the anaplastic lymphoma kinase (ALK) gene. This has considerable implications for treatment because these patients are highly responsive to ALK-specific kinase inhibitors such as crizotinib.

From NanoString Technologies 13 Dec 2012

American Association of Anatomist announces winners of Young Investigator Awards

The American Association of Anatomist's (AAA) Young Investigator Awards combine three long-standing AAA awards-Bensley, Herrick, and Mossman-with the Morphological Sciences Award, all recognizing investigators in the early stages of their careers who have made important contributions to biomedical science through their research in cell/molecular biology, developmental biology, comparative neuroanatomy, or the morphological sciences.

12 Dec 2012

Drugs that bind to specific serotonin receptors can improve and impair female sexual function

Drugs that bind to specific serotonin receptors in the brain can both improve and impair female sexual function in non-human primates.

12 Dec 2012

Epi-marks can lead to homosexuality

Epigenetics - how gene expression is regulated by temporary switches, called epi-marks - appears to be a critical and overlooked factor contributing to the long-standing puzzle of why homosexuality occurs.

12 Dec 2012

Acetylon announces results from selective HDAC 1/2 inhibitor preclinical study on SCD and bT

Acetylon Pharmaceuticals Inc., a leader in targeted epigenetic drug discovery and development for enhanced therapeutic outcomes, today announced results from a preclinical study of a selective histone deacetylase (HDAC) 1/2 inhibitor for the treatment of sickle cell disease (SCD) and beta-thalassemia (bT) at the 54th Annual Meeting of the American Society of Hematology (ASH), taking place in Atlanta, Georgia.

11 Dec 2012

Immune dysfunction pinpointed in developmental disorder

Children with neurodevelopmental abnormalities resulting from duplication of the methyl-CpG binding protein 2 gene also have impaired T-helper-cell 1 responses, research shows.

10 Dec 2012

New study could help develop anti-inflammatory drugs with fewer side effects

10 Dec 2012

FoxP3 gene expression identifies ALS disease progression in 80% of patients

The debilitating symptoms of amyotrophic lateral sclerosis, or ALS, appear to be increased by a lack of inflammation-reducing T cells, report scientists from the Methodist Neurological Institute in an upcoming print issue of The EMBO Molecular Medicine Journal.

10 Dec 2012

Gene Expression News and Research

Further Reading

Germ cell removal may promote longevity

Study investigates muscle weakness in mouse model of Down syndrome

Human nociception genes mapped out

Paternal exposure to cocaine can impair gene expression and behavior in their offspring

Fluidigm, GIS announce establishment of first single-cell genomics research center in Asia

National Cheng Kung University kicks off 23rd International Conference on Genome Informatics

Administration of N2O + ISO appears to have negative effect on fetal development

TSEC strategy can benefit postmenopausal women

Study focuses on nontraditional lifestyle of Retinoblastoma tumor suppressor proteins

New diagnostic assay for screening ALK fusions in non-small cell lung carcinoma

American Association of Anatomist announces winners of Young Investigator Awards

Drugs that bind to specific serotonin receptors can improve and impair female sexual function

Epi-marks can lead to homosexuality

Acetylon announces results from selective HDAC 1/2 inhibitor preclinical study on SCD and bT

Immune dysfunction pinpointed in developmental disorder

New study could help develop anti-inflammatory drugs with fewer side effects

FoxP3 gene expression identifies ALS disease progression in 80% of patients

Noncoding DNA sequence required for epidermal differentiation

Adiponectin level may underpin atherogenic haptoglobin phenotype

CRP40 may have pathogenic role in schizophrenia

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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