Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Two proteins bind together to ignite and sustain malignant brain tumors

Two previously unassociated proteins known to be overly active in a variety of cancers bind together to ignite and sustain malignant brain tumors, a research team led by scientists at The University of Texas MD Anderson Cancer Center reports this week in the journal Cancer Cell.

22 Oct 2011

Agilent announces winners of 2011 eMerging Insights grant program

Agilent Technologies Inc. today announced the winners of the 2011 eMerging Insights grant program: Dr. Michael J. MacCoss of the University of Washington and Dr. Peter J. Park of Harvard University. Each will be awarded $75,000 toward their ongoing research on open source data-integration tools.

21 Oct 2011

AR gene has opposite effects on prostate and breast cancers

Researchers at Cleveland Clinic have discovered that a gene - known as an androgen receptor (AR) - is found in both prostate and breast cancers yet has opposite effects on these diseases.

18 Oct 2011

Achievement of pre-clinical milestone triggers $4M payment from GSK to Epizyme

Epizyme, Inc., a company leading the discovery and development of personalized therapeutics for genetically-defined cancer patients, today announced the achievement of pre-clinical milestones in its alliance with GlaxoSmithKline (GSK), triggering $4 million in milestone payments.

15 Oct 2011

NextBio predicts mechanisms underlying drug toxicity and identifies new cancer biomarker

New research presented this week highlights the ability of NextBio to help life scientists and clinicians investigate publicly available genomic data to assess biological mechanisms underlying drug toxicity, as well as discover prospective cancer biomarkers for further validation.

15 Oct 2011

Nature publishes Sangamo's gene correction strategy for A1AT deficiency

Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced the publication of a preclinical study demonstrating highly specific, functional correction of the alpha 1-antitrypsin (A1AT) gene defect in patient-derived induced pluripotent stem cells (iPSCs) using zinc finger nucleases.

14 Oct 2011

NanoString introduces nCounter Analysis System

NanoString Technologies, Inc., a privately held provider of life science tools for translational research and developer of molecular diagnostics, today announced the launch of its second generation nCounter Analysis System.

From NanoString Technologies 13 Oct 2011

Idera announces new data on novel gene-silencing oligonucleotide technology

Idera Pharmaceuticals, Inc. today presented new data on its novel gene-silencing oligonucleotide (GSO) technology at the Cell Symposium on Regulatory RNAs in Chicago, IL.

12 Oct 2011

New technique could give a preview of which eggs are likely to make the most viable embryos

Given the stakes of in vitro fertilization, prospective parents and their doctors need the best information they can get about the eggs they will extract, attempt to fertilize, and implant. New research at Brown University and Women & Infants Hospital of Rhode Island has found a way to see which genes each egg cell is expressing without harming it.

7 Oct 2011

Researchers show how nuclear receptors battle each other during fruit fly metamorphosis

Growing up just got more complicated. Thomas Jefferson University biochemistry researchers have shown for the first time that the receptor for a major insect molting hormone doesn't activate and repress genes as once thought. In fact, it only activates genes, and it is out-competed by a heme-binding receptor to repress the same genes during the larval to pupal transition in the fruit fly.

7 Oct 2011

University of Leicester's public lectures to explore reality of toxic damage

The genetic and biochemical consequences of exposure to toxins and mutagens are the theme of the next in a series of accessible lecture events at the University of Leicester.

7 Oct 2011

Ibris to develop a quick and economical analysis of tissue from breast cancer biopsies

The National Institutes of Health (NIH) has awarded a Rutgers-affiliated company $207,000 to develop a quick and economical analysis of tissue from breast cancer biopsies. The technology is designed to predict how aggressive a common form of breast cancer is likely to be, helping physicians and patients plan effective therapies that minimize side effects.

7 Oct 2011

Affymetrix commercializes 18 new array designs for whole-transcriptome analysis

Affymetrix, Inc. today announced commercialization of 18 new array designs for whole-transcriptome analysis of model and applied research organisms that will allow scientists to obtain a more complete gene expression view than traditional 3' biased arrays.

7 Oct 2011

CSHL publishes 'The Mammary Gland as an Experimental Model' book

Studies of mammary gland biology are essential in the fight against breast cancer. Moreover, the mammary gland represents an excellent model system for investigation of physiological and pathological processes that occur throughout the body.

4 Oct 2011

Santaris Pharma to report new clinical data from miravirsen Phase 2a study on HCV

Santaris Pharma A/S, a clinical-stage biopharmaceutical company focused on the discovery and development of microRNA and mRNA-targeted therapies, today announced the Company will report new clinical data results from the miravirsen Phase 2a proof-of-concept study to treat patients infected with the Hepatitis C virus (HCV) in a late-breaking oral presentation session at the American Association for the Study of Liver Diseases (AASLD) 2011 annual meeting.

4 Oct 2011

Sangamo's SB-509 fails to meet key endpoints in Phase 2b study for diabetic neuropathy

Sangamo BioSciences, Inc. today announced that its Phase 2b study (SB-509-901) did not meet its primary or secondary clinical endpoints in subjects with moderate severity diabetic neuropathy (DN) as compared to placebo.

3 Oct 2011

Combination of P16 immunohistochemistry, DNA qPCR can accurately detect oropharyngeal cancer

Researchers have determined that a combination of P16 immunohistochemistry and DNA qPCR to test for viral E6 can accurately determine the oropharyngeal squamous cell carcinoma, a form of head and neck cancer, which derive from HPV16, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

3 Oct 2011

Jeffrey C. Hall, Michael W. Young and Michael Rosbash to receive 2011 Louisa Gross Horwitz Prize

Columbia University will award the 2011 Louisa Gross Horwitz Prize to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their work on the molecular basis of circadian rhythms, the first demonstration of a molecular mechanism for behavior.

1 Oct 2011

Scientists discover that DNA modifications in brain cells change due to stimulated brain activity

Johns Hopkins scientists investigating chemical modifications across the genomes of adult mice have discovered that DNA modifications in non-dividing brain cells, thought to be inherently stable, instead underwent large-scale dynamic changes as a result of stimulated brain activity.

1 Oct 2011

United Nations 66th General Assembly to discuss how to reduce NCDs

University of Bergen researchers have contributed to an international declaration on the prevention of non-communicable diseases. Now the UN is discussing the issue.

30 Sep 2011

Gene Expression News and Research

Further Reading

Two proteins bind together to ignite and sustain malignant brain tumors

Agilent announces winners of 2011 eMerging Insights grant program

AR gene has opposite effects on prostate and breast cancers

Achievement of pre-clinical milestone triggers $4M payment from GSK to Epizyme

NextBio predicts mechanisms underlying drug toxicity and identifies new cancer biomarker

Nature publishes Sangamo's gene correction strategy for A1AT deficiency

NanoString introduces nCounter Analysis System

Idera announces new data on novel gene-silencing oligonucleotide technology

New technique could give a preview of which eggs are likely to make the most viable embryos

Researchers show how nuclear receptors battle each other during fruit fly metamorphosis

University of Leicester's public lectures to explore reality of toxic damage

Ibris to develop a quick and economical analysis of tissue from breast cancer biopsies

Affymetrix commercializes 18 new array designs for whole-transcriptome analysis

CSHL publishes 'The Mammary Gland as an Experimental Model' book

Santaris Pharma to report new clinical data from miravirsen Phase 2a study on HCV

Sangamo's SB-509 fails to meet key endpoints in Phase 2b study for diabetic neuropathy

Combination of P16 immunohistochemistry, DNA qPCR can accurately detect oropharyngeal cancer

Jeffrey C. Hall, Michael W. Young and Michael Rosbash to receive 2011 Louisa Gross Horwitz Prize

Scientists discover that DNA modifications in brain cells change due to stimulated brain activity

United Nations 66th General Assembly to discuss how to reduce NCDs

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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