Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Gene expression levels may reveal stage of Huntington's disease

A survey of the genome of patients with Huntington's Disease (HD) has identified potential markers of the progression of this devastating neurological disorder.

16 Aug 2005

DNA chip technology helps with discovery of new type 2 diabetes gene

In a new study appearing in the August 12 issue of the journal Cell, the investigators first identified genes that were altered in their level of expression in islets isolated from people with type 2 diabetes.

13 Aug 2005

Pre-mRNA that codes for inflammatory protein identified

In a discovery that upends a longstanding tenet of human biology, University of Utah School of Medicine researchers have shown that a key process in gene regulation can occur in human platelets, unique cells that are unusual because they don't have a nucleus (anucleate).

11 Aug 2005

How some antibiotics kill bacteria

Researchers have uncovered how members of one family of antibiotics kill bacteria that make people sick.

11 Aug 2005

Low levels of folate linked to lower birth rates

Mothers-to-be with lower levels of the vitamin folate in their body during early pregnancy are more likely to have babies with lower, or less healthy, birth weights, a study has revealed.

4 Aug 2005

New study aims to understand the intricate biochemistry governing gene regulation

In their efforts to understand the complex biology of life, scientists often seek to isolate individual elements of the puzzle for study, to break the problem down to a more manageable size. Single genes and molecules are closely analyzed to better understand their specific interactions with other single entities within larger systems.

4 Aug 2005

Customized gene chip offers clues to prognosis in cases of neuroblastoma

Rather than covering the entire genome, the microarray focuses on suspect regions of chromosomes for signs of deleted genetic material known to play a role in the cancer.

2 Aug 2005

Customized gene chip will offer clues to prognosis in cases of neuroblastoma

Genetics researchers have developed a customized gene chip to rapidly scan tumor samples for specific DNA changes that offer clues to prognosis in cases of neuroblastoma, a common form of children's cancer.

2 Aug 2005

Aging profile of the human brain differs greatly from that seen in chimpanzees

Researchers have found that the two primary areas of the human brain appear to age in radically different ways: The cortex used in higher-level thought undergoes more extensive changes with age than the cerebellum, which regulates basic processes such as heartbeat, breathing and balance.

2 Aug 2005

Aging and gene expression in the primate brain

While medical science and a healthy lifestyle can help increase life expectancy, many aspects of aging and longevity are beyond our control. Published this week in the open-access journal PLoS Biology, Michael Eisen and colleagues shed light on these genetic factors by identifying sets of genes whose expression changes with age in human and chimp brains.

2 Aug 2005

Controlling the expression of genes by turning them on or off could produce a drug for the treatment or cure of almost any disease

A new technique aimed at directly controlling the expression of genes by turning them on or off at the DNA level could lead to drugs for the treatment or cure of many diseases, say researchers at UT Southwestern Medical Center.

1 Aug 2005

New findings could help scientists design more effective treatments to slow or halt the progression of HIV infection

Random fluctuations in gene expression can influence the fates of cells infected with human immunodeficiency virus (HIV) far more than previously thought, according to new research from Howard Hughes Medical Institute (HHMI) researchers at the University of California, Berkeley.

28 Jul 2005

Stress delays wound healing

Wound healing is slow when an animal is stressed, but extra oxygen almost completely reverses the effect, according to researchers at the University of Illinois at Chicago.

28 Jul 2005

Bone marrow may be source of new egg-cell generation

Last year a group of Massachusetts General Hospital (MGH) researchers announced surprising findings that female mice - contrary to longstanding theories of mammalian reproductive physiology - retained the ability to make new egg cells or oocytes into adulthood.

27 Jul 2005

Single protein regulates secretion levels - helps stem cells become secretory cells

Johns Hopkins researchers have discovered that a single protein regulates secretion levels in the fruit fly's salivary gland and its skin-like outer layer.

26 Jul 2005

More efficient genome-mining technique

An innovative new statistical method, described in the open-access journal PLoS Biology, streamlines the computation required to identify all the potential locations in the genome that influence a particular physical trait, or phenotype.

26 Jul 2005

University of Florida researcher finds way to explore role of microRNAs in specific tissue

University of Florida researchers have learned how to selectively shut down a flyweight-sized genetic molecule that packs a heavyweight punch, a discovery that may help doctors better understand cancer, birth defects and other health problems.

20 Jul 2005

One of the first studies to define how unique we are on the genetic level

We all share the same genetic code, but a team from the Institute of Food Research (IFR) has found that the way our genes function varies significantly between individuals, particularly in some key areas including the immune system.

19 Jul 2005

New search method could aid in the discovery of biomarkers for breast cancer

Using a super-efficient method they invented to search for a type of cancer-related change in all genes of a cell, Dana-Farber Cancer Institute researchers have discovered new evidence about how the "microenvironment" of breast cancers helps drive the cancers' growth and migration.

13 Jul 2005

Sirna Therapeutics granted new UK patents

Sirna Therapeutics has announced that the United Kingdom (UK) Patent Office has granted the Company two additional short interfering RNA (siRNA) target patents. The first patent covers any siRNA with one or more chemical modifications targeting Vascular Endothelial Growth Factor (VEGF).

12 Jul 2005