Genes News and Research

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NCoR deficiency may pump up muscles and prevent diabetes

Two independent studies in the Nov. 11 issue of the journal Cell, a Cell Press publication, suggest a common way to pump up muscles and prevent diabetes. The key is a molecule required for fine-tuning metabolism by selectively and subtly modifying core metabolic programs.

11 Nov 2011

New unsuspected role for nuclear receptor corepressor protein

By knocking out a key regulatory protein, scientists at the University of California, San Diego School of Medicine and the Ecole Polytechnique Federale de Lausanne (EPFL) in Switzerland dramatically boosted insulin sensitivity in lab mice, an achievement that opens a new door for drug development and the treatment of diabetes.

11 Nov 2011

Insights into potential causes of temporomandibular joint disorders

New findings about painful jaw problems that plague millions of Americans are leading to a better understanding of pain disorders.

11 Nov 2011

eButton combines the powers of cameras, GPS, and other sensors to combat obesity

People attempting to lose weight won't need to track their daily food intake anymore, thanks to a wearable, picture-taking device created at the University of Pittsburgh. eButton -- a device worn on the chest (like a pin) that contains a miniature camera, accelerometer, GPS, and other sensors -- captures data and information of health activities, eliminating the need for daily self-reporting.

10 Nov 2011

Combination of azacitidine and entinostat shows promise against NSCLC

A new type of therapy aimed at reversing the gene-silencing that promotes cancer-cell growth has shown promising results in a small clinical trial conducted by researchers at the Johns Hopkins Kimmel Cancer Center.

10 Nov 2011

Study reveals role of circadian rhythms in regenerative capacity of skin stem cells

The investigation reveals the role of the daily biological clock (circadian rhythms) in the regenerative capacity of skin stem cells. Disruption of this rhythm results in premature tissue ageing and a greater predisposition to the development of skin tumours. The

10 Nov 2011

World-renowned cardiologist receives 2011 TCT Career Achievement Award

Eric J. Topol, MD, a world-renowned cardiologist and physician-scientist, was presented the 2011 TCT Career Achievement Award in a ceremony held today during the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

10 Nov 2011

UC Riverside professor to co-lead '1000 Fungal Genomes' project

Jason Stajich, an assistant professor of plant pathology and microbiology at the University of California, Riverside, is a member of an international research team that, in collaboration with the Joint Genome Institute of the U.S. Department of Energy, has embarked on a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of Life.

10 Nov 2011

BGI, Children's Hospital of Philadelphia partner to target pediatric diseases

The Children's Hospital of Philadelphia and BGI, the world's largest genomics institute, today announced they have formed a partnership, BGI@CHOP, to conduct large-scale human genome sequencing and bioinformatics analysis at a newly established, state-of-the-art Joint Genome Center at Children's Hospital.

10 Nov 2011

Ground-breaking study into causes of high blood pressure

A researcher from the University of Leicester's Department of Cardiovascular Sciences has been involved in a ground-breaking study into the causes of high blood pressure.

9 Nov 2011

Treatments can help most HCM patients

Most of the 600,000 Americans with hypertrophic cardiomyopathy (HCM) -- a genetic heart muscle disease -- can live normal life spans, according to the first science-based guideline for diagnosing and treating this disorder.

9 Nov 2011

Novel mathematical method reveals genetic distinction between individuals

At a time when profound gaps remain in our understanding of how one person's genes differ from another person's, developing accurate methods to interpret the human genome is essential to uncover population history, population relationships and the genetic basis of some of the most common diseases affecting society.

9 Nov 2011

UCSB researchers study how genotypes can express themselves differently as a function of culture

Two psychologists at UC Santa Barbara have provided a new twist on the old adage that people are products of both nature and nurture, in introducing a framework for understanding how these influences interact.

9 Nov 2011

Johns Hopkins researchers unravel how breast cancer metastasizes

The spread of breast cancer is responsible for more than 90 percent of breast cancer deaths. Now, the process by which it spreads—or metastasizes—has been unraveled by researchers at Johns Hopkins. Reporting in two papers, the researchers have discovered the switch that enables breast cancer cells to travel to and be received in the lungs.

9 Nov 2011

'Second hit' determines immune response against developing Burkitt's lymphoma

The human c-myc gene encodes a transcription factor (MYC) involved in the regulation of a vast number of other genes - it has been estimated that the transcription of about one in six genes is somehow under the control of MYC.

9 Nov 2011

ScreenCell, Transgenomic sign collaboration and distribution agreement for CTC technology

Transgenomic, Inc. and ScreenCell, a privately-held company, today announced the signing of a perpetual, worldwide collaboration and distribution agreement for ScreenCell's Isolation Devices and Dilution Buffers, designed for the collection of Circulating Tumor Cells (CTCs) in peripheral blood.

9 Nov 2011

New breast and ovarian cancer vaccine in the pipeline: Study

A new vaccine is being tried clinically to combat tumor cells in a small study of advanced breast and ovarian cancer patients. The results show that there is improvement in overall survival times and stopping the disease for a handful of breast cancer patients.

8 Nov 2011

Study looks at influence of father's depression on his children

There have been numerous studies that looked at the effect of mother's depression upon her children. But there have been no studies that explore the influence a father's depression on his children.

8 Nov 2011

Study: Genes that are active in brain are transcribed with special mechanism

Knowledge about the development of the nervous system is of the greatest importance for us to understand the function of the brain and brain disorders. Researchers at Uppsala University have examined the key step when genes are read and found that genes that are active in the brain are transcribed with a special mechanism.

8 Nov 2011

Prefrontal cortex neurons from individuals with autism show changes in chromatin structures

Neurons in the prefrontal cortex of individuals with autism show changes at numerous sites across the genome, according to a study being published Online First by the Archives of General Psychiatry, one of the JAMA/Archives journals.

8 Nov 2011