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New study helps explain why lung tumors turn aggressive

Lung cancer is the number 1 killer among cancers, especially when it is of the non-small cell type. Among these, adenocarcinomas are the most common and aggressive type. These tumors also show a strong tendency to show dedifferentiation, or loss of the features that characterize a mature lung cell.

28 Aug 2019

Researchers gain new insights into types of germ cell tumors

Germ cell tumors constitute a diverse group of rare tumors, which occur in the testes, ovaries and also in other places. Some germ cell tumors exist prenatally, while others present during or after puberty. The majority is benign.

27 Aug 2019

Astrocytes help the brain to establish long-lasting memories

Star-shaped cells called astrocytes help the brain establish long-lasting memories, Salk researchers have discovered.

25 Aug 2019

New mechanisms to enable regeneration of injured nerve fibers

Injuries to nerve fibers in the brain, spinal cord, and optic nerves usually result in functional losses as the nerve fibers are unable to regenerate.

23 Aug 2019

Super-powered immune cells to attack tumors

Ground-breaking immune therapy promises to deliver vital evidence in the fight against cancer as researchers from the Centre for Cancer Biology open a new clinical trial using genetically engineered immune cells to treat solid cancers.

23 Aug 2019

Researchers unlock mysteries surrounding maternal/fetal cellular communication during pregnancy

Researchers have unlocked mysteries surrounding how a pregnant mother's cells and her fetus' cells communicate throughout pregnancy.

22 Aug 2019

New method prevents the release of synthetic DNA from genetically modified cells

The method prevents a gene that encodes a synthetic protein from spreading into the wild and stabilizes it so that it cannot mutate and lose its function.

21 Aug 2019

Researchers decipher defence mechanism of filamentous fungi

An international research team led by the University of Göttingen has deciphered the defence mechanism of filamentous fungi.

21 Aug 2019

California clamps down on amateur use of gene-editing technologies

California state officials have passed the first law to prohibit genetic biohacking in an effort to regulate at-home gene editing.

20 Aug 2019

Researchers find biological system that manages cells' response to opioid drug exposure

A team at Scripps Research in Florida has discovered a biological system that manages cells' response to opioid drug exposure. The unexpected discovery offers new ideas for improving the safety of the one of the most effective, and most abused, group of pain medications.

19 Aug 2019

Removal of a critical enzyme may help cases of sepsis finds research

Scientists at the University of California San Diego School of Medicine have shown that removal of an enzyme called the PH domain Leucine-rich repeat Protein Phosphatase 1 (PHLPP1) could help laboratory mice with sepsis in a model they had created for their experiment. The study titled, “PHLPP1 counter-regulates STAT1-mediated inflammatory signalling,” was published this week in the journal eLife.

15 Aug 2019

Chlamydia vaccine shows promise after a successful clinical trial

A vaccine against the sexually transmitted infection (STI) chlamydia is now a substantial step closer to reality after successfully passing its Phase 1 clinical trial.

14 Aug 2019

Bile pigment may play an unexpected role in protecting the brain

In studies in mice, Johns Hopkins Medicine researchers report they have found that bilirubin, a bile pigment most commonly known for yellowing the skin of people with jaundice, may play an unexpected role in protecting brain cells from damage from oxidative stress.

From Johns Hopkins Medicine 13 Aug 2019

NIH-funded clinical trial will evaluate seasonal influenza vaccines with two experimental adjuvants

An early-stage clinical trial is evaluating two licensed seasonal influenza vaccines, administered with or without novel adjuvants, for their safety and ability to generate an immune response.

9 Aug 2019

Longer-lived, but less toxic drug may work better for pancreatic cancer

Unlike many other cancers, most pancreatic tumors are rock hard.

9 Aug 2019

ISCT expresses concern about companies offering unproven T-cell preservation services

ISCT, the International Society for Cell and Gene Therapy, the global professional society of clinicians, researchers, regulatory specialists, technologists and industry partners in the cell and gene therapy sector, today announces its objection to linking the benefits of cellular immunotherapy, in particular Chimeric Antigen Receptor (CAR) T-cell therapy, with recent market offerings for third party cryopreserving and banking of T-cells for future therapeutic use.

8 Aug 2019

New improved model for cancer wasting syndrome cachexia

A new model of cancer-related cachexia promises to help scientists understand why patients with cancer show severe wasting, which in turn may drive the development of better therapies.

7 Aug 2019

Pitt researchers first to grow genetically modified miniature human livers in the lab

Researchers at the University of Pittsburgh School of Medicine are the first to grow genetically modified miniature human livers in the laboratory, to emulate human liver disease progression and test therapeutics.

7 Aug 2019

New mouse model could lead to a better understanding of cachexia syndrome

A study published in Cell Reports Aug. 6 describes the generation of a new mouse model developed at Hollings Cancer Center that could lead to a better understanding of the cachexia syndrome. This wasting condition, characterized by excessive weight loss, has one of the highest incidences in pancreatic cancer patients.

6 Aug 2019

FDA announces new policy framework for development of regenerative medicine products

Today the U.S. Food and Drug Administration announced a comprehensive policy framework for the development and oversight of regenerative medicine products, including novel cellular therapies.

5 Aug 2019