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Identification of cholesterol regulating genes by targeted RNAi-screening

Scientists at the European Molecular Biology Laboratory (EMBL) and the University of Heidelberg, Germany, have come a step closer to understanding how cholesterol levels are regulated. In a study published today in the journal Cell Metabolism, the researchers identified 20 genes that are involved in this process. Besides giving scientists a better idea of where to look to uncover the mechanisms that ensure cholesterol balance is maintained, the discovery could lead to new treatments for cholesterol-related diseases.

7 Jul 2009

U.S. military broad-based influenza monitoring system

The recent global swine flu outbreak has underscored the critical need for good surveillance and rapid access to epidemiological data. The US military, starting with early monitoring efforts in the 1970s, has developed a broad-based influenza monitoring system. In an article published in the September 2009 issue of the American Journal of Preventive Medicine, researchers describe this little-known national jewel that has repeatedly made notable contributions to global influenza control through close collaboration with CDC, the Food and Drug Administration (FDA), the WHO, and many other partners.

7 Jul 2009

New strategies to improve treatment and prevent heart failure in children

Structural cardiovascular abnormalities present at birth are the leading cause of heart failure in children. Nearly half a million children in the United States have structural heart problems ranging in severity from relatively simple issues, such as small holes between chambers of the heart, to very severe malformations, including complete absence of one or more chambers or valves.

7 Jul 2009

Research pinpoints antibodies that may prevent Alzheimer's

Antibodies to a wide range of substances that can aggregate to form plaques, such as those found in Alzheimer's patients, have been identified in the blood and cerebrospinal fluid of healthy people. Levels of these antibodies decline with age and, in Alzheimer's patients, with increasing progression of the disease.

6 Jul 2009

Potential new target for acute myeloid leukemia

Dr. John Dick, Senior Scientist at the Ontario Cancer Institute, the research arm of Princess Margaret Hospital, co-led a multinational team that has developed the first leukemia therapy that targets a protein, CD123, on the surface of cancer stem cells that drive acute myeloid leukemia (AML), which is an aggressive disease with a poor outcome.

6 Jul 2009

The surprising effect of cannabis on morphine dependence

Injections of THC, the active principle of cannabis, eliminate dependence on opiates (morphine, heroin) in rats deprived of their mothers at birth. This has been shown by a study carried out by Valérie Daugé and her team at the Laboratory for Physiopathology of Diseases of the Central Nervous System (UPMC / CNRS / INSERM) in the journal Neuropsychopharmacology. The findings could lead to therapeutic alternatives to existing substitution treatments.

6 Jul 2009

Swine flu different from ordinary flu in a number of ways

Scientists say new research has shown that the new H1N1 influenza strain (swine flu) is somewhat less contagious than seasonal flu, but appears to be more able to cause stomach upsets.

5 Jul 2009

Major new e-science resource for biologists

The University of Manchester and the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) have launched a major new e-science resource for biologists - which could accelerate research into treatments for H1N1 flu and cancer.

From The University of Manchester 2 Jul 2009

Bioethicists lead call for public debates on future uses of stem cells

More than 40 scientists, bioethicists, lawyers and science journal editors are calling on their colleagues, policy makers and the public to begin developing guidelines for the research and reproductive use of stem cell-derived eggs and sperm, even though such use may be a decade or more away.

2 Jul 2009

Doping drug does little to improve cyclists' performance

Scientists in New Zealand say many top cyclists may be putting their health at risk for no competitive gain by taking the doping drug pseudoephedrine.

2 Jul 2009

New peripherally inserted central catheter mimics nature

A novel coating being used on a new peripherally inserted central catheter (PICC) from r4 Vascular mimics the cell layer found on natural tissue surfaces.

30 Jun 2009

Research shows it is possible to freeze embryos and reduce multiple pregnancies in PGD cycles without adversely affecting pregnancy rates

Transferring just one embryo at a time to a woman's womb after embryos have undergone preimplantation genetic diagnosis (PGD) and freezing at the blastocyst stage has become a real option after researchers achieved pregnancy rates that were as good as those for blastocysts that had not had a cell removed for PGD before freezing. Their results mean that it will be possible to reduce the number of multiple pregnancies after PGD and the consequent complications associated with these pregnancies.

30 Jun 2009

Research examines history of H1N1 and provides cautionary tale about the use of extinct viruses

The current H1N1 swine flu strain has genetic roots in an illness that sickened pigs at the 1918 Cedar Rapids Swine Show in Iowa, report infectious disease experts at the University of Pittsburgh Graduate School of Public Health in the New England Journal of Medicine.

30 Jun 2009

Discovery of second gene linked to familial testicular cancer

Specific variations or mutations in a particular can gene raise a man's risk of familial, or inherited, testicular germ-cell cancer, the most common form of this disease, according to new research by scientists at the National Institutes of Health.

29 Jun 2009

Chewing robot helps study dental wear formation on teeth

The UK spends around £2.5 billion each year on dental materials to replace or strengthen teeth. The Chewing Robot is a new biologically inspired way to test dental materials and it will be shown to the public for the first time at this year's Royal Society Summer Science Exhibition [30 June to 4 July].

29 Jun 2009

U.S. swine flu cases reach one million

The Associated Press/Washington Post reported that U.S. health officials on Thursday said they believe as many as 1 million Americans have been infected with H1N1 and "6 percent or more of some urban populations are infected." The estimates were based upon survey data collected by health officials and mathematical modeling.

29 Jun 2009

Mexican, Chilean Presidents appeal for developing countries access to H1N1 vaccine

Mexican President Felipe Calderon and Chilean President Michelle Bachelet on Thursday emphasized the importance of developing countries having access to a vaccine that offers protection against the H1N1 (swine flu), "that has killed over 200 people and infected tens of thousands worldwide," AFP/MSN Philippine News reports.

29 Jun 2009

New understanding of how cells cover gaps

Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, came a step closer to understanding how cells close gaps not only during embryonic development but also during wound healing. Their study, published this week in the journal Cell, uncovers a fundamental misconception in the previous explanation for a developmental process called dorsal closure.

28 Jun 2009

How ‘high carb’ foods cause heart attacks

It has been commonly known for a number of years that certain foods, such as white bread and corn flakes, are bad for cardiac health, but new research from Israeli scientists shows just how 'high carb' foods cause heart attacks.

28 Jun 2009

Nanofluidic biopsy detects subtle changes in cancer cells

By taking two standard laboratory techniques - capillary electrophoresis and antibody-based protein detection - and shrinking them to the nanoscale, researchers at the Stanford University School of Medicine have created a new method for detecting miniscule changes in the levels of proteins associated with cancer.

28 Jun 2009