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Phase II study results of Lilly Oncology's tasisulam for metastatic melanoma to be presented at 46th ASCO

Lilly released results today from a Phase II study evaluating Lilly Oncology's tasisulam, a novel anti-cancer agent, in patients with metastatic melanoma, the deadliest form of skin cancer. Study results will be presented during the 46th Annual Meeting of the American Society of Clinical Oncology (ASCO) held in Chicago, Ill. on June 6, 2010.

21 May 2010

TAP to unveil innovative RAFT system at TERMIS Conference

The Automation Partnership, a world leader in the design and development of innovative automation for life science applications, is pleased to announce it will be unveiling RAFT (Real Architecture for 3D Tissue), its innovative system for generating reproducible, 3D collagen tissue constructs on TAP Stand 1 at the Tissue Engineering and Regenerative Medicine International Society Conference on June 13-17, in Galway, Ireland.

20 May 2010

Vanderbilt University orders Bruker's AVANCE III 900 US2 NMR spectrometer

Bruker, the leader in analytical magnetic resonance instrumentation, announces a major multi-systems NMR order from Vanderbilt University, including an ultra-high field AVANCE™ III 900 US2 NMR spectrometer. This purchase was made possible in large part by the American Recovery and Reinvestment Act. Vanderbilt will use these NMR instruments for a broad range of biophysical and structural analyses in biomedical research, as well as for cancer drug discovery using fragment-based approaches and structure-based drug design.

20 May 2010

Results from Phase 1 clinical trials of TRC105, TRC102, and TRC093 to be presented at ASCO 2010

TRACON Pharmaceuticals, a biotechnology company that develops targeted therapies for oncology and ophthalmology, announced today that results from Phase 1 clinical trials of TRC105, TRC102, and TRC093 will be presented at the annual meeting of the American Society of Clinical Oncology on June 5-7, 2010 in Chicago, IL.

19 May 2010

UNC-developed technique has broad applications in cancer, biomedical research

A precise understanding of cellular growth and movement is the key to developing new treatments for cancer and other disorders caused by dysfunctional cell behavior. Recent breakthroughs in genetic medicine have uncovered how genes control whether cellular proteins are turned 'on' or 'off' at the molecular level, but much remains to be understood about how protein signaling influences cell behavior.

17 May 2010

caprotec bioanalytics closes EUR 4 million Series B Financing Round

caprotec bioanalytics GmbH today announced the closing of a EUR 4 million ($5.1M) Series B Financing Round with existing investors Creathor Venture, IBB Beteiligungsgesellschaft, ERP Startfonds, and well-known private investors. The proceeds will enable further development and marketing of the Company's proprietary CCMS (Capture Compound Mass Spectrometry) platform technology for analyzing complex protein mixtures.

14 May 2010

Optivia Biotechnology launches OptiDDI Suite for assessing transporter-related DDIs

Optivia Biotechnology Inc., a leading provider of in vitro transporter assay services, today announced the launch of the OptiDDITM Suite, a novel assay panel that assesses the most clinically significant transporter-related drug-drug interactions (DDIs), as identified by the International Transporter Consortium (ITC) in its report "Membrane Transporters in Drug Development" (Nature Reviews-Drug Discovery, March 2010).

12 May 2010

Compugen discovers CGEN-928 as antibody drug target for treatment of multiple myeloma

Compugen Ltd. announced today the discovery and initial experimental validation of CGEN-928 as a drug target for the treatment of multiple myeloma. In recently completed studies, CGEN-928, a membrane protein which previously had no known function or potential clinical utility, demonstrated broad expression in human multiple myeloma tumor cells, including drug resistant and aggressive primary tumor cell lines.

12 May 2010

Pregnant women at risk for pregnancy problems caused by oral bacteria

Even healthy pregnant women can be at risk for pregnancy problems caused by oral bacteria. Researchers from Case Western Reserve University began to understand which bacteria from the 700 species living in the mouth are responsible for the growing health problem of preterm and stillbirths.

11 May 2010

CrystalGenomics completes European Phase I SAD study of CG400549 antibiotic candidate

CrystalGenomics, Inc., a novel drug R&D company announced today that the Phase I SAD (Single Ascending Dose) study for its novel antibiotic candidate, CG400549, has been successfully completed in Europe.

11 May 2010

Chemical changes in genetic material regulate activity of many genes

Chemical changes in the genetic material, known as epigenetic modifications, regulate the activity of many genes. Thus, attachment of methyl groups to DNA often inactivates important cellular growth brakes. Therefore, this process called methylation is believed to be a major cause of uncontrolled division of cancer cells. Specific enzymes, the DNA methyltransferases, are responsible for methylation.

7 May 2010

Neurons' complicated tree-like structure formation unravelled

A breakthrough about the formation and maintenance of tree-like nerve cell structures could have future applications in the treatment of neurodegenerative diseases and the repair of injuries in which neurons are damaged. The findings by the international team led by Prof. Benjamin Podbilewicz of the Technion-Israel Institute of Technology Faculty of Biology are published in the May 6th issue of Science Express.

7 May 2010

New measurement technique can lead to better treatment strategies for malaria and sickle-cell disease

Thanks to an interdisciplinary team of researchers, scientists now have a more complete understanding of one of the human body's most vital structures: the red blood cell.

7 May 2010

Peptides: A new clue on the origins of life

Emory University scientists have discovered that simple peptides can organize into bi-layer membranes. The finding suggests a "missing link" between the pre-biotic Earth's chemical inventory and the organizational scaffolding essential to life.

7 May 2010

New study may help design better vaccines for dengue fever

Some of the human immune system's defences against the virus that causes dengue fever actually help the virus to infect more cells, according to new research published today in the journal Science.

7 May 2010

Cryo-EM images shed light on virus structure, function

UCLA researchers report in the April 30 edition of the journal Cell that they have imaged a virus structure at a resolution high enough to effectively "see" atoms, the first published instance of imaging biological complexes at such a resolution.

5 May 2010

Medication used to treat heart arrhythmias also reduces myotonic dystrophy: Researchers

A medication most often used to treat heart arrhythmias also reduces a central symptom of myotonic dystrophy, the most common type of muscular dystrophy in adults.

5 May 2010

New data on salt-sensitive hypertension to be presented at ASH 2010 conference

With governmental authorities, academicians, healthcare providers and industry grappling with the level of salt in the diet in an effort to reduce its impact on high blood pressure, new data evaluating a potential genetic component to salt-sensitive hypertension will be presented at the American Society of Hypertension, Inc.'s 25th Annual Scientific Meeting and Exposition (ASH 2010).

4 May 2010

New research suggests tumor-secreted exosomes inhibit immune response, enhance tumor metastasis

Current research suggests that tumor-secreted exosomes inhibit the immune response, enhancing tumor metastasis. The related report by Liu et al, "Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells," appears in the May 2010 issue of The American Journal of Pathology.

3 May 2010

Tamiflu and two other drugs used to treat influenza appear safe for pregnant women and babies: Study

Tamiflu and two other drugs used to treat influenza appear safe for pregnant women and their babies, researchers at UT Southwestern Medical Center have found in a retrospective study of 239 cases of women who received the medications during pregnancy.

28 Apr 2010

Membrane News and Research

Phase II study results of Lilly Oncology's tasisulam for metastatic melanoma to be presented at 46th ASCO

TAP to unveil innovative RAFT system at TERMIS Conference

Vanderbilt University orders Bruker's AVANCE III 900 US2 NMR spectrometer

Results from Phase 1 clinical trials of TRC105, TRC102, and TRC093 to be presented at ASCO 2010

UNC-developed technique has broad applications in cancer, biomedical research

caprotec bioanalytics closes EUR 4 million Series B Financing Round

Optivia Biotechnology launches OptiDDI Suite for assessing transporter-related DDIs

Compugen discovers CGEN-928 as antibody drug target for treatment of multiple myeloma

Pregnant women at risk for pregnancy problems caused by oral bacteria

CrystalGenomics completes European Phase I SAD study of CG400549 antibiotic candidate

Chemical changes in genetic material regulate activity of many genes

Neurons' complicated tree-like structure formation unravelled

New measurement technique can lead to better treatment strategies for malaria and sickle-cell disease

Peptides: A new clue on the origins of life

New study may help design better vaccines for dengue fever

Cryo-EM images shed light on virus structure, function

Medication used to treat heart arrhythmias also reduces myotonic dystrophy: Researchers

New data on salt-sensitive hypertension to be presented at ASH 2010 conference

New research suggests tumor-secreted exosomes inhibit immune response, enhance tumor metastasis

Tamiflu and two other drugs used to treat influenza appear safe for pregnant women and babies: Study

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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