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Nanoparticles from crab shells show promise for drug delivery

Nanoparticles made of chitosan, a naturally occuring polymer isolated from crab and shrimp shells, have shown promise as carriers of anticancer drugs, antitumor genes, and other novel therapeutic agents.

22 Jan 2007

Dendrimer-based targeted delivery of an apoptotic sensor in cancer cells

Taking a critical step toward the development of a multifunctional nanoscale anticancer agent that can detect cancer, treat it, and then report on the success or failure of that treatment, investigators at the University of Michigan have developed a nanoscale sensor of cell death.

22 Jan 2007

Cetuximab with radiotherapy does not increase side effects for head and neck cancer patients

The addition of Cetuximab (brand name Erbitux) to radiation therapy treatments does not increase the rate or duration of some side effects in the treatment of advanced head and neck cancers, according to a study presented at the plenary session today at the Multidisciplinary Head and Neck Cancer Symposium, co-sponsored by the American Society for Therapeutic Radiology and Oncology, the American Society for Clinical Oncology and the American Head and Neck Society.

18 Jan 2007

Microfluidics gives boost to protein crystallization

Proteins produced by cancer cells are among the common targets for anticancer agents, and thanks to efforts in proteomics and cancer genomics, the number of potential protein targets is increasing exponentially.

16 Jan 2007

New treatment technique for decontaminating flood water

Engineers have developed a system that uses a simple water purification technique that can eliminate 100 percent of the microbes in New Orleans water samples left from Hurricane Katrina. The technique makes use of specialized resins, copper and hydrogen peroxide to purify tainted water.

10 Jan 2007

Stem cells derived from human amniotic fluid appear to offer many of the benefits of embryonic stem cells

...including the ability to grow into brain, muscle, bone and other tissues -- according to a study published in the Jan. 7 online edition on the journal Nature Biotechnology, the Washington Post reports.

9 Jan 2007

Ryogen licenses gene patent to Invitrogen

Ryogen LLC announced today that the company have entered into a nonexclusive license agreement with Invitrogen Corporation, whereby Invitrogen has licensed from Ryogen the patent directed to the clinically important Aminopeptidase P gene.

9 Jan 2007

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

By combining a quantum dot with a novel carrier of the magnetic resonance imaging (MRI) agent gadolinium, a team of investigators at the University of Maastricht, in The Netherlands, has developed a nanoparticle that can spot apoptosis, or programmed cell death, using both MRI and fluorescence imaging.

8 Jan 2007

Better magnetic nanoparticles

Using a polymer coating designed to resemble the outer surface of a cell membrane, a team of investigators led by Steve Armes, Ph.D., of the University of Sheffield in the United Kingdom, has created a highly stable, biocompatible magnetic nanoparticle expected to improve the sensitivity of magnetic resonance imaging (MRI).

18 Dec 2006

Improved cell therapy for cartilage repair

Artificially cultured cartilage cells, grown outside of the body for reparing damaged tissue, prove to be different from original cartilage tissue.

2 Dec 2006

Researchers discover protein interaction that may explain how Huntington's disease affects the brain

The findings, published in and featured on the cover of the current issue of Human Molecular Genetics, show how the mutated Huntington's protein interacts with another protein to cause dramatic accumulation of cholesterol in the brain.

2 Dec 2006

Test strips for the rapid detection of cocaine

Saving the life of a poisoning victim is often a matter of minutes. It is best when the emergency doctor can perform a reliable diagnosis on the spot to determine which poison or what type of drug overdose a patient is suffering from. Complicated laboratory analyses and a complex apparatus are out of place in the emergency room.

21 Nov 2006

Watching a tumor cell migrate

Using a microfluidics device designed to reproduce the physical microenvironment of small blood vessels and the spaces between cells, researchers at the National University of Singapore have imaged single tumor cells deforming as they migrate through the device.

20 Nov 2006

Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery

Though researchers have made substantial progress in developing drug-ferrying nanoparticles that successfully target tumor cells in living animals, including humans, investigators have only now started the detailed work needed to identify formulation parameters that would optimize drug delivery to malignant cells.

6 Nov 2006

Self-assembling nanoparticle releases drug into cell cytoplasm

A growing body of research leaves no doubt that nanoparticles can transport drugs into cancer cells, but what is less clear is that the drug payload can exit the tiny endosomes that pull nanoparticles into cells.

30 Oct 2006

Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse

By studying a gene earlier linked to deafness in humans, researchers now have new insight into the molecular process by which components of the inner ear send messages to the brain.

20 Oct 2006

New Purdue biochip may speed drug development

Purdue University researchers have developed a biochip that measures the electrical activities of cells and is capable of obtaining 60 times more data in just one reading than is possible with current technology.

20 Oct 2006

Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis

One of the unusual properties of tumor cells is that their cell membranes are more fluid and less rigid than those of normal cells.

16 Oct 2006

Phase separation of lipid membranes analyzed with high-resolution secondary ion mass spectrometry

Understanding the chemical composition and organization of cell membranes - what components reside next to each other, how many of each there are and how they respond to their environment - may reveal the secret lives of cells in both health and disease.

9 Oct 2006

New understanding of how cells defend themselves

Biologists at the EPFL (Ecole Polytechnique Federale de Lausanne) have unveiled a new twist in a metabolic pathway that cells use to defend themselves against toxins made by disease-causing bacteria.

21 Sep 2006