Messenger RNA (mRNA) News and Research

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ASO may correct striatal transcriptional abnormalities and improve behavioral problems in HD mice

Findings from postmortem studies of the brains of Huntington's Disease (HD) patients suggest that transcriptional dysregulation may be an early step in the pathogenesis of HD before symptoms appear. Other studies report transcriptional alterations in the brains of some mouse models of HD.

27 Aug 2013

Scientists prove 50-year-old hypothesis of RNA 'higher-order' structure

When Francis Crick and James Watson discovered the double helical structure of deoxyribonucleic acid (DNA) in 1953, it began a genetic revolution to map, study, and sequence the building blocks of living organisms.

27 Aug 2013

Shire Renews Rare Genetic Disease Collab With Santaris

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23 Aug 2013

Shire Renews Rare Genetic Disease Collab With Santaris

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23 Aug 2013

Noninvasive urine test can accurately monitor risk of kidney rejection

Levels of a protein in the urine of kidney transplant recipients can distinguish those at low risk of developing kidney injury from those at high risk, a study suggests. The results also suggest that low levels of this protein, called CXCL9, can rule out rejection as a cause of kidney injury.

23 Aug 2013

Medical investigators discover new aspect of gene-splicing process that produces mRNA

A rare, small RNA turns a gene-splicing machine into a switch that controls the expression of hundreds of human genes. Howard Hughes Medical Institute Investigator and professor of Biochemistry Gideon Dreyfuss, PhD, and his team from the Perelman School of Medicine at the University of Pennsylvania, discovered an entirely new aspect of the gene-splicing process that produces messenger RNA (mRNA).

22 Aug 2013

UC Davis graduate discovers how eIF4E protein acts upon cancer-promoting mRNA molecules

Researchers have long known that high levels of a specific protein in human cells are linked to tumor growth - but no one has fully understood how.

21 Aug 2013

Illumina announces availability of its newest reagent kits for MiSeq benchtop sequencer

Illumina, Inc. today announced the availability of its newest reagent kits for the MiSeq, the industry's most accurate and easiest-to-use benchtop sequencer. The improved chemistry doubles sequencing output to 15 gigabases (Gb) by increasing the number of sequencing reads (up to 25 million reads) and overall read length (up to 2x300 base pairs). These innovations enable researchers to perform new applications including exome sequencing on the MiSeq.

From Illumina, Inc. 19 Aug 2013

Study suggests Braintone has neuroprotective effects on ischemia-induced brain damage

Recently, the importance of the neurovascular unit, which is comprised of neurons, endothelial cells and astrocytes, has received great attention in the field of stroke, because stroke affects not only neurons, but also astrocytes and microvessels.

17 Aug 2013

BIDMC cardiovascular research team receives $4M grant to identify mRNA biomarkers in heart disease

A cardiovascular research team from Beth Israel Deaconess Medical Center (BIDMC) and Brigham and Women's Hospital (BWH), led by BIDMC Principal Investigator Saumya Das, MD, PhD, has been awarded a $4 million Common Fund grant from the National Institutes of Health (NIH) as part of a newly formed program on Extracellular RNA Communication.

17 Aug 2013

Scientists shed new light on molecular causes of age related degenerative disease

An international collaboration jointly led by scientists from Trinity College Dublin has shed new light on the origins and molecular causes of age related degenerative conditions including Motor Neurone Disease (MND). The new perspective provided by this work may lead the way to new treatments and early diagnoses.

16 Aug 2013

Study suggests that about 70% of total Alzheimer's risk is hereditary

Alzheimer's, and intervene to reduce the risk of the disease? We may be closer to that goal, thanks to a team at the University of Kentucky. Researchers affiliated with the UK Sanders-Brown Center on Aging have completed new work in Alzheimer's genetics; the research is detailed in a paper published today in the Journal of Neuroscience.

16 Aug 2013

Osteoarthritis research: an interview with Dr Deborah Mason, Cardiff University

Osteoarthritis is an extremely common condition affecting about 8 million people in the UK. The elderly are particularly susceptible, with up to 45% of people over 65 years, having the disease.

14 Aug 2013

Pregnant rats fed with high-fat diet experience preeclampsia-like syndromes

Preeclampsia is a relatively common pregnancy disorder, characterized by primary hypertension and proteinuria. In patients with severe preeclampsia, eclampsia can develop, causing nervous system symptoms and signs.

9 Aug 2013

Cancer-linked mitosis: an interview with Professor Scott Kern, Johns Hopkins University School of Medicine

Mitosis is the process by which a cell gives rise to two daughter cells. It’s the basis behind the growth of the human body, the renewal of the human body as it ages, and unfortunately, the growth of cancers.

7 Aug 2013

Disruption to TOP3B gene increases susceptibility to schizophrenia and a learning disorder

A team of researchers have shown that schizophrenia and a disorder associated with autism and learning difficulties share a common biological pathway. This is one of the first times that researchers have uncovered genetic evidence for the underlying causes of schizophrenia.

5 Aug 2013

ASH to award 2013 William Dameshek Prize to Andrew S. Weyrich

The American Society of Hematology will present the 2013 William Dameshek Prize to Andrew S. Weyrich, PhD, of The University of Utah for his seminal research on the cellular and molecular causes of blood clots.

2 Aug 2013

Discovery may help explain how anti-inflammatory steroid drugs work

A gene long presumed dead comes to life under the full moon of inflammation, Stanford University School of Medicine scientists have found.

23 Jul 2013

Investigators report complete catalog of genes expressed in retina

Investigators at Massachusetts Eye and Ear and Harvard Medical School have published the most thorough description of gene expression in the human retina reported to date. In a study published today in the journal BMC Genomics, Drs. Michael Farkas, Eric Pierce and colleagues in the Ocular Genomics Institute at Mass. Eye and Ear reported a complete catalog of the genes expressed in the retina.

20 Jul 2013

Study shows link between FTO, ghrelin and impaired brain food-cue responsivity

Individuals carrying the "obesity-risk" allele of the fat mass and obesity associated gene, FTO, are prone to obesity and obesity related eating behaviors such as increased food consumption, preference for high fat foods and lack of satiation after eating.

16 Jul 2013

Messenger RNA (mRNA) News and Research

ASO may correct striatal transcriptional abnormalities and improve behavioral problems in HD mice

Scientists prove 50-year-old hypothesis of RNA 'higher-order' structure

Shire Renews Rare Genetic Disease Collab With Santaris

Shire Renews Rare Genetic Disease Collab With Santaris

Noninvasive urine test can accurately monitor risk of kidney rejection

Medical investigators discover new aspect of gene-splicing process that produces mRNA

UC Davis graduate discovers how eIF4E protein acts upon cancer-promoting mRNA molecules

Illumina announces availability of its newest reagent kits for MiSeq benchtop sequencer

Study suggests Braintone has neuroprotective effects on ischemia-induced brain damage

BIDMC cardiovascular research team receives $4M grant to identify mRNA biomarkers in heart disease

Scientists shed new light on molecular causes of age related degenerative disease

Study suggests that about 70% of total Alzheimer's risk is hereditary

Osteoarthritis research: an interview with Dr Deborah Mason, Cardiff University

Pregnant rats fed with high-fat diet experience preeclampsia-like syndromes

Cancer-linked mitosis: an interview with Professor Scott Kern, Johns Hopkins University School of Medicine

Disruption to TOP3B gene increases susceptibility to schizophrenia and a learning disorder

ASH to award 2013 William Dameshek Prize to Andrew S. Weyrich

Discovery may help explain how anti-inflammatory steroid drugs work

Investigators report complete catalog of genes expressed in retina

Study shows link between FTO, ghrelin and impaired brain food-cue responsivity

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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